ChemicalBook CAS DataBase List 5-BROMO-2-METHOXY-3-NITRO-PYRIDINE

5-BROMO-2-METHOXY-3-NITRO-PYRIDINE synthesis

8synthesis methods

Product Name:5-BROMO-2-METHOXY-3-NITRO-PYRIDINE
CAS Number:152684-30-5
Molecular formula:C6H5BrN2O3
Molecular Weight:233.02

67443-38-3 Synthesis

67443-38-3
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$5.00/1g

124-41-4 Synthesis

124-41-4
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152684-30-5
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$6.00/1g

Yield: 98%

Reaction Conditions:

in methanol at 0 - 20; for 19 h;

Steps:

5.a
a) 5 -bromo-2-(methyloxy)-3 -nitropyridine. To a stirred solution of 5-bromo-2-chloro-3-nitropyridine (86 mmol) in methanol (75 mL) at 0 ⁰C was added drop wise a solution of 25% w/w sodium methoxide in methanol (20 mL, 87 mmol) and methanol (20 mL) over 10 min. After stirring at 0 ⁰C for 1 h the reaction was allowed to warm to room temperature and stirred for 18 h. The reaction was concentrated under vacuum to approximately half its volume then poured into ice water (-500 mL). The precipitate that formed was filtered, washed with cold water, and dried under vacuum to give the title product (98%) as a pale yellow solid. MS(ES)+ m/e 233.2 [M+H]+.

References:

SMITHKLINE BEECHAM CORPORATION WO2009/39140, 2009, A1 Location in patent:Page/Page column 52

67-56-1 Synthesis