6-Hydroxypurine synthesis
- Product Name:6-Hydroxypurine
- CAS Number:68-94-0
- Molecular formula:C5H4N4O
- Molecular Weight:136.11
7440-02-0
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$14.39/1slug
69-89-6
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$6.00/1g
68-94-0
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$5.00/100mg
Yield:68-94-0 1.37 g (67.2%)
Reaction Conditions:
with acetic acid in methanol;propan-1-ol;ethyl acetate;
Steps:
11.C C.
2.18 g (4.5 mM) of xanthine (B.) and 2.6 g of Raney-nickel (treated with 0.1% aqueous acetic acid) were refluxed in 30 ml of 1-propanol for 2.5 hr. The nickel was filtered off and the solution evaporated in vacuo to dryness. The residue was dissolved in 40 ml of ethyl acetate and extracted with sodium bicarbonate solution. The formed solid is filtered off and the organic phase evaporated in vacuo to dryness (1.95 g). A dichloromethane solution, comprising 2% of methanol, was purified on 19 g of silicagel in a column. Crystallization from ethyl acetate gave 1.37 g (67.2%) of hypoxanthine with mp 159-161° C., a second crop gave 0.4 g (2.0%) of hypoxanthine.
References:
US6413975,2002,B1
890-38-0
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68-94-0
693 suppliers
$5.00/100mg
73-24-5
888 suppliers
$6.00/5g
68-94-0
693 suppliers
$5.00/100mg
60100-09-6
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120-73-0
169 suppliers
$9.00/100mg
73-24-5
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$6.00/5g
68-94-0
693 suppliers
$5.00/100mg
73-40-5
733 suppliers
$5.00/5g
