Betamethasone 21-acetate synthesis
- Product Name:Betamethasone 21-acetate
- CAS Number:987-24-6
- Molecular formula:C24H31FO6
- Molecular Weight:434.5
467-55-0
211 suppliers
$33.60/100MG
987-24-6
275 suppliers
$76.00/2 mg
Yield:-
Steps:
Multi-step reaction with 13 steps
1.1: 95 percent / pyridine / 20 °C
2.1: 72 percent / m-iodoxybenzoic acid; diphenyl diselenide / toluene / 12 h / Heating
3.1: hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
3.2: 95 percent / potassium hydroxide / ethane-1,2-diol; H2O / 5 h / 195 - 197 °C
4.1: pyridine; ammonium chloride / 125 - 135 °C
4.2: acetic acid; chromium trioxide / H2O; 1,2-dichloro-ethane / 1 h / 20 °C
4.3: 57 percent / aluminium oxide / benzene / 2 h
5.1: 91.7 percent / hydrogen peroxide; sodium hydroxide / methanol / 2 h / 20 °C
6.1: 95 percent / pyridine / 20 °C
7.1: 70 percent / triethyl orthoformate; p-toluenesulfonic acid / CH2Cl2 / 20 h / 20 °C
8.1: 72 percent / tetrahydrofuran; diethyl ether / 72 h / 60 °C
9.1: m-iodoxybenzoic acid; diphenyl diselenide / toluene / 22 h / Heating
9.2: 50 percent / p-toluenesulfonic acid / CH2Cl2 / 4 h / 20 °C
10.1: perchloric acid; 1,3-dibromo-5,5-dimethylhydantoin / dimethylformamide / 3 h / cooling
10.2: 75.8 percent / sodium hydroxide / CH2Cl2; methanol; H2O / 2 h / cooling
11.1: 80 percent / hydrofluoric acid / tetrahydrofuran; CH2Cl2 / 5 h / -70 - 0 °C
12.1: 100 percent / anhydrous calcium chloride; calcium oxide; iodine / methanol / 1 h / 25 - 27 °C
13.1: 180 mg / acetic acid / acetone; H2O / 3 h / Heating
References:
Kongkathip, Ngampong;Kongkathip, Boonsong;Noimai, Naratitt [Synthetic Communications,2006,vol. 36,# 7,p. 865 - 874]
378-44-9
607 suppliers
$39.00/50mg
108-24-7
5 suppliers
$14.00/250ML
987-24-6
275 suppliers
$76.00/2 mg
910-99-6
8 suppliers
inquiry
987-24-6
275 suppliers
$76.00/2 mg
37413-99-3
12 suppliers
inquiry
987-24-6
275 suppliers
$76.00/2 mg
14135-32-1
3 suppliers
inquiry
987-24-6
275 suppliers
$76.00/2 mg