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Betamethasone

hormone drugs Chemical Properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Betamethasone
Betamethasone structure
CAS No.
378-44-9
Chemical Name:
Betamethasone
Synonyms
Bifas;Bebate;Becort;6beta)-;Cidoten;Bedifos;Betalon;Pertene;Dermabet;Hormezon
CBNumber:
CB7392335
Molecular Formula:
C22H29FO5
Formula Weight:
392.46
MOL File:
378-44-9.mol

Betamethasone Properties

Melting point:
235-237°C
alpha 
D +108° (acetone)
Density 
1.1283 (estimate)
refractive index 
118 ° (C=1, Dioxane)
storage temp. 
0-6°C
solubility 
Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
form 
neat
Merck 
14,1180
CAS DataBase Reference
378-44-9(CAS DataBase Reference)
NIST Chemistry Reference
Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn,T
Risk Statements  40-48/20/21-61
Safety Statements  22-36-45-53
WGK Germany  2
RTECS  TU4000000
HS Code  29379000
Hazardous Substances Data 378-44-9(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P501 Dispose of contents/container to..…

Betamethasone price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 18081 Betamethasone ≥95.0% (HPLC), pharmaceutical impurity standard 378-44-9 50mg $135 2018-11-20 Buy
Sigma-Aldrich 1066009 Betamethasone United States Pharmacopeia (USP) Reference Standard 378-44-9 200mg $352.8 2018-11-20 Buy
Cayman Chemical 20363 Betamethasone ≥98% 378-44-9 25mg $42 2018-11-19 Buy
Cayman Chemical 20363 Betamethasone ≥98% 378-44-9 50mg $80 2018-11-19 Buy
Sigma-Aldrich B9675 Betamethasone meets USP testing specifications 378-44-9 25mg $88 2018-11-20 Buy

Betamethasone Chemical Properties,Uses,Production

hormone drugs

Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone .
Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension.
Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections.
The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 ℃, slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.

Uses

Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.

production method

According to U.S. Patent No. 3,164,618, betamethasone acetate is dealt with hydrochloric acid in methanol-chloroform-water mixture , it can be converted to betamethasone.

Category

Toxic substances

Toxicity grading

Middle toxic

Acute toxicity

Oral-mouse LD50:> 4500 mg/kg

Flammability and hazard characteristics

Combustible;Its combustion produces toxic fumes of fluoride.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Dry powder , foam, sand, carbon dioxide, water spray.

Chemical Properties

White to Off-White Solid

Uses

glucocorticoid, antiinflammatory

Uses

Betamethasone is a glucocorticoid used as an anti-inflammatory agent.

Uses

anti-inflammatory, immunosuppressive

brand name

Celestone Syrup and Tablets (Schering).

General Description

Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.
Betamethasone valerate, USP (17-valerate)
Betamethasone acetate, USP (21-acetate)
Betamethasone sodium phosphate, USP (21-sodiumphosphate)
Betamethasone dipropionate, USP (17-propionate,21-propionate).

Purification Methods

Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]

Betamethasone Preparation Products And Raw materials

Raw materials

Preparation Products


Betamethasone Suppliers

Global( 330)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 894 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1662 55
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58

View Lastest Price from Betamethasone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-17 Betamethasone
378-44-9
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-03-08 Betamethasone
378-44-9
US $600.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-08-10 Betamethasone
378-44-9
US $10.00 / KG 1KG 99% 100 MT per month Hebei Guanlang Biotechnology Co., Ltd.

Betamethasone Spectrum


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