ChemicalBook CAS DataBase List Formamide, N-(2-aminophenyl)-

Formamide, N-(2-aminophenyl)- synthesis

5synthesis methods

Product Name:Formamide, N-(2-aminophenyl)-
CAS Number:34840-28-3
Molecular formula:C7H8N2O
Molecular Weight:136.15

64-18-6 Synthesis

64-18-6
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$22.12/250ML

95-54-5 Synthesis

95-54-5
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$9.00/1g

34840-28-3
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Yield:34840-28-3 95%

Reaction Conditions:

with [Ch-OSO₃H]₃W₁₂PO₄₀ in water at 27; for 0.0833333 h;Green chemistry;chemoselective reaction;

Steps:

Experimental procedures for N-formylation of amines

A mixture of amine (1 mmol), aq. formic acid (98%, 3 mmol,0.11 mL) and 20 mg of HIL was thoroughly mixed in a mortar fol-lowed by grinding at room temperature (27 ± 1C) (Scheme 2).The syrupy mixture got solidified within 5-15 min. The mixturewas pulverized till the completion of reaction as indicated by TLC(Table 4). The reaction mass was then dissolved in ethanol torecover the insoluble catalyst. The filtered catalyst was dried at80C under vacuum for 2 h after thorough washing with ethanol.Recovered HIL was recycled in the model reaction for six times tocheck its catalytic efficiency. The products were recrystallized fromhot ethanol. The structures of the products were confirmed by1HNMR, IR spectroscopy and elemental analysis. The spectral data forall compounds is in good agreement with the reported compounds.

References:

Satasia, Shailesh P.;Kalaria, Piyush N.;Raval, Dipak K. [Journal of Molecular Catalysis A: Chemical,2014,vol. 391,# 1,p. 41 - 47]