Methyl 2-bromomethyl-3-nitrobenzoate synthesis
- Product Name:Methyl 2-bromomethyl-3-nitrobenzoate
- CAS Number:98475-07-1
- Molecular formula:C9H8BrNO4
- Molecular Weight:274.07
59382-59-1
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$15.00/5g
98475-07-1
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$7.00/250mg
Yield:98475-07-1 100%
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethaneReflux;
Steps:
9A.a
Step a) Methyl 2-(bromomethyl)-3-nitrobenzoate A solution of 21 g (109 mmol) of methyl 2-methyl-3-nitrobenzoate in 300 ml of carbon tetrachloride is stirred under reflux, 23 g (130 mmol, 1.2 eq.) of N-bromosuccinimide and 1.8 g (11 mmol, 0.1 eq.) of 2,2'-azobis-2-methylpropanenitrile are added and the mixture is stirred under reflux overnight. After cooling to RT, the reaction mixture is diluted with dichloromethane, washed repeatedly with water, dried over sodium sulphate, filtered and concentrated under reduced pressure.Yield: 31 g (quantitative)HPLC (Method 12): Rt=4.33 min;MS (ESIpos): m/z=273 [M+H]+;1H-NMR (300 MHz, DMSO-d6): δ=8.16 (d, 1H), 8.11 (d, 1H), 7.74 (t, 1H), 5.03 (s, 2H), 3.92 (s, 3H).
References:
Bayer Healthcare AG US2010/10060, 2010, A1 Location in patent:Page/Page column 19
60-29-7
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59382-59-1
272 suppliers
$15.00/5g
98475-07-1
461 suppliers
$7.00/250mg
109-69-3
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59382-59-1
272 suppliers
$15.00/5g
98475-07-1
461 suppliers
$7.00/250mg
1975-50-4
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98475-07-1
461 suppliers
$7.00/250mg