METHYL 2-CHLORONICOTINATE synthesis
- Product Name:METHYL 2-CHLORONICOTINATE
- CAS Number:40134-18-7
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
67-56-1
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$7.29/5ml-f
2942-59-8
826 suppliers
$5.00/25g
40134-18-7
228 suppliers
$6.00/5g
Yield:40134-18-7 93%
Reaction Conditions:
with thionyl chloride for 8 h;Reflux;
Steps:
1.1 preparation of compound II
To the 250 ml flask is added in three 15.76g (0.1 µM) 2 - chloro -3 - picolinic acid, 100 ml methanol, under the ice-bath adds by drops 17.85g (0.15 µM) thionyl chloride, stirring and heating to reflux, the stirring reaction 8h. Thin layer chromatography tracking response, the raw materials point disappears, stopping the reaction. Reduced pressure distillation to remove the solvent to obtain light yellow 15.95g, yield 93%
References:
Qingdao University of Science and Technology;Wang Minghui;Yuan Jianpo;Huang Xuesong;Xu Liangzhong CN105061399, 2017, B Location in patent:Paragraph 0010; 0029; 0030
2942-59-8
826 suppliers
$5.00/25g
40134-18-7
228 suppliers
$6.00/5g
2942-59-8
826 suppliers
$5.00/25g
77-78-1
322 suppliers
$19.69/1ml
40134-18-7
228 suppliers
$6.00/5g
67-56-1
776 suppliers
$7.29/5ml-f
49609-84-9
249 suppliers
$20.00/5g
40134-18-7
228 suppliers
$6.00/5g
2942-59-8
826 suppliers
$5.00/25g
40134-18-7
228 suppliers
$6.00/5g