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ChemicalBook CAS DataBase List Primidone

Primidone synthesis

6synthesis methods
Primidone, 5-ethyl-5-phenylhexahydropyrimidinedione-4,6 (9.2.1) is synthesized by reacting ethylphenylmalonic acid diamide with formamide [5,6]. An alternative method is the electrolytic reduction of phenobarbital or the catalytic reduction of the appropriate 2-thiobarbituric acid [7].

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 44 percent / 17 h / 22 °C / Irradiation
2: 42 percent / butan-1-ol / 17 h / 22 °C / Irradiation

References:

Paluchowska;Bojarski [Archiv der Pharmazie,1988,vol. 321,# 6,p. 343 - 344]

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