| Identification | More | [Name]
Ethyl N-piperazinecarboxylate | [CAS]
120-43-4 | [Synonyms]
1-CARBETHOXYPIPERAZINE
1-CARBOETHOXYPIPERAZINE
1-ETHOXYCARBONYLPIPERAZINE
1-ETHXOYCARBONYLPIPERAZINE
1-PIPERAZINECARBOXYLIC ACID ETHYL ESTER
AKOS BC-0597
ETHYL 1-PIPERAZINECARBOXYLATE
ETHYL N-PIPERAZINECARBOXYLATE
ETHYL N-PIPERAZINOCARBOXYLATE
ETHYL PIPERAZINE-1-CARBOXYLATE
LABOTEST-BB LT00138086
MONO-CARBETHOXYPIPERAZINE
N-CARBETHOXYPIPERAZINE
N-CARBOETHOXY PIPERAZINE
PIPERAZINE-1-CARBOXYLIC ACID ETHYL ESTER
RARECHEM AH CK 0098
TIMTEC-BB SBB003993
Ethyl 1-piperazinocarboxylate
Ethylcarbonyl piperazine
ethylcarbonylpiperazine | [EINECS(EC#)]
204-395-2 | [Molecular Formula]
C7H14N2O2 | [MDL Number]
MFCD00005964 | [Molecular Weight]
158.2 | [MOL File]
120-43-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear light yellow oily liquid | [Melting point ]
120 °C | [Boiling point ]
273 °C (lit.) | [density ]
1.08 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.477(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Oily Liquid | [pka]
8.50±0.10(Predicted) | [color ]
Clear light yellow | [Water Solubility ]
soluble | [BRN ]
125780 | [InChI]
1S/C7H14N2O2/c1-2-11-7(10)9-5-3-8-4-6-9/h8H,2-6H2,1H3 | [InChIKey]
LNOQURRKNJKKBU-UHFFFAOYSA-N | [SMILES]
CCOC(=O)N1CCNCC1 | [Uses]
Intermediate. | [CAS DataBase Reference]
120-43-4(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Piperazinecarboxylic acid, ethyl ester(120-43-4) | [EPA Substance Registry System]
120-43-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xn,T | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
TL1378000
| [Hazard Note ]
Toxic | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29335995 | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow oily liquid | [Synthesis]
Piperazine (2 g, 23.2 mmol) and deionized water (10 mL) were added to a reaction flask and stirred at 25 °C until completely dissolved, then cooled to 0 °C. A methanol solution (20 mL) of ethyl chloroformate (1.26 g, 11.6 mmol) was slowly added dropwise with stirring. After the dropwise addition was completed, the reaction system was warmed to 25 °C and stirring was continued for 4 hours. Upon completion of the reaction, saturated aqueous sodium chloride solution (30 mL) and dichloromethane (200 mL) were added to the reaction solution for extraction and separation. The organic layer was collected and dried with anhydrous sodium sulfate. The organic solvent was removed by distillation under reduced pressure, and the resulting crude product was purified by column chromatography (eluent: dichloromethane/methanol, 40:1, v/v/v/v) to give ethyl N-piperazinecarboxylate (0.62 g, 33.7% yield) as a white solid. | [References]
[1] Patent: CN103664899, 2017, B. Location in patent: Paragraph 0465-0469
[2] Patent: CN103664925, 2018, B. Location in patent: Paragraph 0458; 0461; 0462
[3] Journal of the Chemical Society, 1929, p. 50
[4] Journal of Organic Chemistry, 1948, vol. 13, p. 134,138
[5] Chemische Berichte, 1933, vol. 66, p. 113,116 |
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