| Identification | More | [Name]
Sulfamonomethoxine | [CAS]
1220-83-3 | [Synonyms]
4-AMINO-N-[6-METHOXY-4-PYRIMIDINYL]BENZENESULFONAMIDE
AKOS B014359
ART-CHEM-BB B014359
SULFAMONOMETHOXIN
SULFAMONOMETHOXINE
4-amino-n-(6-methoxy-4-pyrimidinyl)-benzenesulfonamid
daimeton
dj-1550
ds-36
ici32525
n(sup1)-(6-methoxy-4-pyrimidinyl)-sulfanilamid
ro4-3476
SMM
Sulfamomomethoxine(sodium)
SULAMONOMETHOXINE
4-Amino-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide
Sulfamomonethoxine
Sulfamonomethoxine Base
SULPHAMONOMETHOXINE
Sulphanyl acid N-(6-methoxypyrimidin-4-yl) amide | [EINECS(EC#)]
624-483-8 | [Molecular Formula]
C11H12N4O3S | [MDL Number]
MFCD00063466 | [Molecular Weight]
280.3 | [MOL File]
1220-83-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White To Off-White Crystalline Powder | [Melting point ]
203-2060C | [Boiling point ]
513℃ | [density ]
1.3936 (rough estimate) | [refractive index ]
1.6200 (estimate) | [Fp ]
>110°(230°F) | [storage temp. ]
0-6°C | [solubility ]
methanol: soluble10mg/mL | [form ]
powder | [pka]
pKa 5.94 (Uncertain) | [color ]
white to white with yellow cast | [Water Solubility ]
Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol | [Usage]
Protein binding. Inhibitor of enzyme | [BRN ]
621128 | [Major Application]
clinical testing | [InChI]
InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15) | [InChIKey]
WMPXPUYPYQKQCX-UHFFFAOYSA-N | [SMILES]
C1(S(NC2C=C(OC)N=CN=2)(=O)=O)=CC=C(N)C=C1 | [CAS DataBase Reference]
1220-83-3(CAS DataBase Reference) | [EPA Substance Registry System]
1220-83-3(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H317-H319-H335 | [Precautionary statements ]
P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
2
| [RTECS ]
WP0550000
| [HazardClass ]
IRRITANT | [HS Code ]
29350090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 | [Toxicity]
LD50 oral in rabbit: > 10gm/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White To Off-White Crystalline Powder | [Uses]
antibacterial | [Uses]
Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim | [Definition]
ChEBI: Sulfamonomethoxine is a sulfonamide and a member of benzenes. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034 | [General Description]
Chemical structure: sulfonamide | [Biochem/physiol Actions]
Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid. | [Synthesis]
Sodium sulfamethoxazole is commonly used in clinical practice, and the preparation method of sodium sulfamethoxazole includes the following steps:
(1) Add sulfamethoxazole and sodium hydroxide into organic solvent, and stir the reaction for 0.5-2 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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