ChemicalBook--->CAS DataBase List--->1220-83-3

1220-83-3

1220-83-3 Structure

1220-83-3 Structure
IdentificationMore
[Name]

Sulfamonomethoxine
[CAS]

1220-83-3
[Synonyms]

4-AMINO-N-[6-METHOXY-4-PYRIMIDINYL]BENZENESULFONAMIDE
AKOS B014359
ART-CHEM-BB B014359
SULFAMONOMETHOXIN
SULFAMONOMETHOXINE
4-amino-n-(6-methoxy-4-pyrimidinyl)-benzenesulfonamid
daimeton
dj-1550
ds-36
ici32525
n(sup1)-(6-methoxy-4-pyrimidinyl)-sulfanilamid
ro4-3476
SMM
Sulfamomomethoxine(sodium)
SULAMONOMETHOXINE
4-Amino-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide
Sulfamomonethoxine
Sulfamonomethoxine Base
SULPHAMONOMETHOXINE
Sulphanyl acid N-(6-methoxypyrimidin-4-yl) amide
[EINECS(EC#)]

624-483-8
[Molecular Formula]

C11H12N4O3S
[MDL Number]

MFCD00063466
[Molecular Weight]

280.3
[MOL File]

1220-83-3.mol
Chemical PropertiesBack Directory
[Appearance]

White To Off-White Crystalline Powder
[Melting point ]

203-2060C
[Boiling point ]

513℃
[density ]

1.3936 (rough estimate)
[refractive index ]

1.6200 (estimate)
[Fp ]

>110°(230°F)
[storage temp. ]

0-6°C
[solubility ]

methanol: soluble10mg/mL
[form ]

powder
[pka]

pKa 5.94 (Uncertain)
[color ]

white to white with yellow cast
[Water Solubility ]

Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol
[Usage]

Protein binding. Inhibitor of enzyme
[BRN ]

621128
[InChI]

InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
[InChIKey]

WMPXPUYPYQKQCX-UHFFFAOYSA-N
[SMILES]

C1(S(NC2C=C(OC)N=CN=2)(=O)=O)=CC=C(N)C=C1
[CAS DataBase Reference]

1220-83-3(CAS DataBase Reference)
[EPA Substance Registry System]

1220-83-3(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

2
[RTECS ]

WP0550000
[HazardClass ]

IRRITANT
[HS Code ]

29350090
[Toxicity]

LD50 oral in rabbit: > 10gm/kg
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Diethyl malonate-->Trichloroethylene-->MALONIC ACID DI-N-BUTYL ESTER-->4-nitrobenzenediazonium chloride-->4-Nitrobenzenesulfonyl chloride
Hazard InformationBack Directory
[Chemical Properties]

White To Off-White Crystalline Powder
[Uses]

antibacterial
[Uses]

Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim
[Definition]

ChEBI: Sulfamonomethoxine is a sulfonamide and a member of benzenes.
[Synthesis Reference(s)]

The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034
[General Description]

Chemical structure: sulfonamide
[Biochem/physiol Actions]

Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

1220-83-3(sigmaaldrich)
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