| Identification | More | [Name]
5-Amino-2-methoxyphenol | [CAS]
1687-53-2 | [Synonyms]
2-METHOXY-5-AMINOPHENOL
3-HYDROXY-4-METHOXYANILINE
5-AMINO-2-METHOXYPHENOL
5-AMINOGUAIACOL
TIMTEC-BB SBB007884
Phenol, 5-amino-2-methoxy-
5-Amino-2-Methoxyphenol 2-Methoxy-5-Aminophenol
5-Amino-2-Methyoxyphenol
3-hydroxy-p-anisidine
5-Amino-2-methoxyphenol, Tech.
5-Aminoguaiacol, Tech
5-AMINO-2-METHOXYPHENOL 99%
COMPOUNDSODIUMNITROPHENOLATE/5-AMINO-2-METHOXYPHENOL | [EINECS(EC#)]
216-873-8 | [Molecular Formula]
C7H9NO2 | [MDL Number]
MFCD00010222 | [Molecular Weight]
139.15 | [MOL File]
1687-53-2.mol |
| Chemical Properties | Back Directory | [Appearance]
grey-brown to dark brown crystalline powder | [Melting point ]
130-132 °C(lit.)
| [Boiling point ]
255.1°C (rough estimate) | [density ]
1.1997 (rough estimate) | [refractive index ]
1.4800 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
slightly soluble | [form ]
powder to crystal | [pka]
10.02±0.10(Predicted) | [color ]
Light yellow to Amber to Dark green | [Water Solubility ]
slightly soluble | [Detection Methods]
HPLC | [BRN ]
2717084 | [InChI]
InChI=1S/C7H9NO2/c1-10-7-3-2-5(8)4-6(7)9/h2-4,9H,8H2,1H3 | [InChIKey]
BLQFHJKRTDIZLX-UHFFFAOYSA-N | [SMILES]
C1(O)=CC(N)=CC=C1OC | [CAS DataBase Reference]
1687-53-2(CAS DataBase Reference) | [NIST Chemistry Reference]
5-Amino-2-methoxyphenol(1687-53-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/22:Harmful by inhalation and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
2811 | [WGK Germany ]
3
| [PackingGroup ]
II | [HS Code ]
29225000 |
| Hazard Information | Back Directory | [Chemical Properties]
grey-brown to dark brown crystalline powder | [General Description]
5-Amino-2-methoxyphenol reacts with ninhydrin to yield tetrahydroindeno[1,2-b]indolones. | [Synthesis]
Commercially available 2-methoxy-5-nitrophenol (40 g, 236.5 mmol) was dissolved in methanol (300 mL) under argon protection and palladium/carbon catalyst (3 g) was added. The suspension was vacuum degassed and purged repeatedly with hydrogen several times. Subsequently, the reaction mixture was stirred at room temperature under hydrogen pressure (40 psi) for 24 hours. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the intermediate 2-methoxy-5-aminophenol (25 g, 76% yield) as a yellow solid. Electrospray ionization mass spectrometry (ESI-MS) showed [M + 1] peak of 140.1, which was consistent with the calculated value. Elemental analysis (C7H9NO2) calculated value: 139.06. | [References]
[1] Patent: WO2015/192981, 2015, A1. Location in patent: Page/Page column 71-72
[2] Gazzetta Chimica Italiana, 1907, vol. 37 II, p. 372
[3] Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912, vol. <5> 21 II, p. 207
[4] Journal of the American Chemical Society, 1948, vol. 70, p. 168,170
[5] Journal of the Chemical Society, 1951, p. 2426,2429 |
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