| Identification | More | [Name]
2-Amino-3-bromo-5-methylpyridine | [CAS]
17282-00-7 | [Synonyms]
2-AMINO-3-BROMO-5-METHYLPYRIDINE
2-AMINO-3-BROMO-5-PICOLINE
2-AMINO-5-METHYL-3-BROMO PYRIDINE
3-BROMO-5-METHYLPYRIDIN-2-AMINE
3-BROMO-5-METHYLPYRIDIN-2-YLAMINE
6-AMINO-5-BROMO-3-PICOLINE
AURORA KA-7917
BUTTPARK 33\04-66
TIMTEC-BB SBB000261
3-Bromo-5-methyl-2-pyridinamine
2-AMINO-3-BROMO-5-METHYLPYRIDINE 98%
2-Pyridinamine, 3-bromo-5-methyl-
2-AMINO-3-BROMO-5-PICOLINE (2-AMINO-3-BROMO-5-METHYLPYRIDINE)
2-Amino-3-bromo-5-methylpyridine, 98+%
2-AMINO-3-BOROMO-5-METHYLPYRIDINE | [EINECS(EC#)]
626-356-2 | [Molecular Formula]
C6H7BrN2 | [MDL Number]
MFCD00068231 | [Molecular Weight]
187.04 | [MOL File]
17282-00-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
73-76 °C (lit.) | [Boiling point ]
252.3±35.0 °C(Predicted) | [density ]
1.5672 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
4.28±0.49(Predicted) | [color ]
Yellow to beige or brown | [Water Solubility ]
Insoluble | [Detection Methods]
HPLC | [BRN ]
471829 | [InChI]
1S/C6H7BrN2/c1-4-2-5(7)6(8)9-3-4/h2-3H,1H3,(H2,8,9) | [InChIKey]
NDPKXEWDWTZBDG-UHFFFAOYSA-N | [SMILES]
Cc1cnc(N)c(Br)c1 | [CAS DataBase Reference]
17282-00-7(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Amino-3-bromo-5-methylpyridine(17282-00-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Uses]
2-Amino-3-bromo-5-methylpyridine may be used in the synthesis of:
- 3-bromo-2-chloro-5-methylpyridine
- 3-bromo-2-fluoro-5-methylpyridine
- 8-methyl-1,2,3,5-tetrahydropyrido[3,4-b][1,4]diazepin-4-one
- 3-bromo-2-(ethylamino)-5-methylpyridine
- (3-bromo-5-methylpyridin-2-yl)aniline
- 5-methyl-3-(phenylethynyl)pyridin-2-amine
- 3-[(2-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine
- 3-[(4-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine
- 3-[(3-chlorophenyl)ethynyl]-5-methylpyridin-2-amine
| [Uses]
2-Amino-3-bromo-5-methylpyridine is used for the preparation of imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines, and imidazo[1,2-d]triazines as JNK and ERK kinase inhibitors
| [References]
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3796 - 3808
[2] Patent: CN107056781, 2017, A. Location in patent: Paragraph 0008
[3] Journal fuer Praktische Chemie (Leipzig), 1989, vol. 331, # 3, p. 369 - 374
[4] Journal fuer Praktische Chemie (Leipzig), 1989, vol. 331, # 3, p. 369 - 374
[5] Tetrahedron, 2011, vol. 67, # 47, p. 9063 - 9066 |
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Jia Xing Isenchem Co.,Ltd
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