| Identification | More | [Name]
Coumarin 120 | [CAS]
26093-31-2 | [Synonyms]
4-Methyl-7-aminocoumarin
7-AMINO-4-METHYL-2H-CHROMEN-2-ONE
7-AMINO-4-METHYLCOUMARIN
AKOS B014362
AMC
BUTTPARK 44\02-66
COUMARIN 120
COUMARIN 440
H-MCA
TIMTEC-BB SBB008517
2H-1-Benzopyran-2-one, 7-amino-4-methyl-
2H-1-Benzopyran-2-one,7-amino-4-methyl-
7-amino-4-methyl-2h-1-benzopyran-2-on
7-Amino-4-methyl-chromen-2-one
7-Amino-4-methylcumarin
C 120
C120
Coumarin,7-amino-4-methyl-
Cumarin120
7-AMINO-4-METHYLCOUMARIN 99% (LASER DY& | [EINECS(EC#)]
247-454-8 | [Molecular Formula]
C10H9NO2 | [MDL Number]
MFCD00006868 | [Molecular Weight]
175.18 | [MOL File]
26093-31-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow beige powder | [Melting point ]
223-226 °C (lit.) | [Boiling point ]
306.47°C (rough estimate) | [density ]
1.1999 (rough estimate) | [refractive index ]
1.5060 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in acetone (10 mg/ml) dimethyl sulfoxide (10 mg/ml) and dimethylformamide. | [form ]
Crystalline Powder | [pka]
1.89 ± 0.20, most basic, temperature:
25 °C | [color ]
Beige to brown | [Sensitive ]
Light Sensitive | [λmax]
351 nm (MeOH); 342 nm (Buffer
pH 7) | [BRN ]
142231 | [Biological Applications]
Identifyingbacteria; measuring urinary kallikrein levels;monitoring platinum(iv) reduction and platinum(ii)reactions in cancer cells; as a substrate for measuringadipinylamidases activity, aromatic amino aciddecarboxylases activity, histone deacetylasesactivity, hydrolases/esterases activity,β-lactamases activity, microbial nitroreductasesactivity, penicillin G acylases activity,proteases/proteinases/peptidases activity,glutamyltransferases activity, tryptophanasesactivity; as an effective antitubercular agent; use astemperature sensor, | [Major Application]
For authentification; dyelasers; color display devices; inks;monitoring underlying corrosion on coated aluminum;photoinitiating systems; recording materials;semiconductor devices; dye-sensitized solar cells(DSCs); mesoporous silica fibers; SiO2 sonogelhybrid materials; textiles; waveguides;whitening agents, | [InChIKey]
GLNDAGDHSLMOKX-UHFFFAOYSA-N | [CAS DataBase Reference]
26093-31-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Coumarin, 7-amino-4-methyl-(26093-31-2) | [EPA Substance Registry System]
26093-31-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29322090 |
| Hazard Information | Back Directory | [Chemical Properties]
Coumarin 120 is Light yellow beige powder
| [Uses]
Coumarin 120 is widely used fluorophore, well-known for preparing fluorogenic substrates for cystine aminopeptidase and other hydrolases. Used as reference compound in enzyme assays.
| [Uses]
suitable for determining polygalacturonase activity | [Uses]
λ max 354 nm in EthanolSuitable as laser dye and used as a fluorescent labeling reagent for trace determination of enzymes. | [Definition]
ChEBI: Coumarin 120 is a member of 7-aminocoumarins. It has a role as a fluorochrome. | [General Description]
7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O. | [Biochem/physiol Actions]
7-Amino-4-methylcoumarin is a coumarin derivative, which serves as a fluorescence reference standard to screen protease inhibitors. | [storage]
+4°C | [Purification Methods]
Dissolve it in 5% HCl, filter and basify with 2M ammonia. The precipitate is dried in a vacuum and recrystallised from dilute EtOH. It yields a blue solution and is light sensitive. [Sigler Synthesis 614 1980, Kanaoka et al. Chem Pharm Bull Jpn 30 1485 1982, Beilstein 18/11 V 445.] |
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