ChemicalBook--->CAS DataBase List--->39711-79-0

39711-79-0

39711-79-0 Structure

39711-79-0 Structure
IdentificationMore
[Name]

N-Ethyl-p-menthane-3-carboxamide
[CAS]

39711-79-0
[Synonyms]

FEMA 3455
N-ETHYL-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE
N-ETHYL-4-MENTHANE-3-CARBOXAMIDE
N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXAMIDE
N-ETHYL-5-METHYL-2-(1-METHYLETHYL)-CYCLOHEXANE-CARBOXYAMIDE
N-ETHYL 5-METHYL-2-ISO-PROPYLCYCLOHEXANECARBOXAMIDE
N-ETHYL-P-MENTHAN 3-CARBOXAMIDE
N-ETHYL-P-MENTHANE-3-CARBOXAMIDE
TIMTEC-BB SBB008527
WS-3
n-ethyl-5-methyl-2-(1-methylethyl)-cyclohexanecarboxamid
ETHYL MENTHANE CARBOXAMIDE
MENTHANE CARBOXAMIDE
N-Ethyl-hexahydro-p-cymene-3-carboxamide
Cyclohexanecarboxamide, N-ethyl-5-methyl-2-(1-methylethyl)-
N-ETHYL-PARA-MENTHANE-3-CARBOXAMIDE
N-Ethyl-2-(isopropyl)-5-methylcyclohexancarboxamid
N-Ethyl-p-methane-3-carboxamide, Ethyl menthane carboxamide, Framidice 3, Menthol Carboxamide WS-3
Menthol Carboxamide WS-3
N-Ethyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
[EINECS(EC#)]

254-599-0
[Molecular Formula]

C13H25NO
[MDL Number]

MFCD00130071
[Molecular Weight]

211.34
[MOL File]

39711-79-0.mol
Chemical PropertiesBack Directory
[Appearance]

white crystalline powder
[Melting point ]

87-102 °C
[alpha ]

D -49 to -54°
[Boiling point ]

351.04°C (rough estimate)
[density ]

0.9305 (rough estimate)
[vapor pressure ]

0.007Pa at 25℃
[FEMA ]

3455
[refractive index ]

1.4410 (estimate)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO: ≥ 100 mg/mL (473.17 mM); Water: < 0.1 mg/mL (insoluble)
[form ]

powder to crystal
[pka]

16.27±0.60(Predicted)
[color ]

White to Almost white
[Odor]

at 25.00 % in dipropylene glycol. mild mentholic minty
[Odor Type]

minty
[Water Solubility ]

insoluble
[JECFA Number]

1601
[Merck ]

14,3825
[InChIKey]

VUNOFAIHSALQQH-UHFFFAOYSA-N
[LogP]

2.902 at 25℃
[CAS DataBase Reference]

39711-79-0(CAS DataBase Reference)
[EPA Substance Registry System]

39711-79-0(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi,Xn
[Risk Statements ]

R36:Irritating to the eyes.
R41:Risk of serious damage to eyes.
R22:Harmful if swallowed.
[Safety Statements ]

S39:Wear eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[WGK Germany ]

2
[HS Code ]

29242990
[Toxicity]

LD50 in mice, rats (g/kg): 5.3, 2.9 orally (Parrish)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

N-Ethyl-p-menthane-3-carboxamide(39711-79-0).msds
Hazard InformationBack Directory
[Chemical Properties]

N-ethyl-p-menthane-3-carboxamide is an odorless white, crystalline solid. The compound has a strong and clear physiological cooling effect and is used mainly in oral care products.
[Chemical Properties]

Slight menthol-like cooling effect aroma
[Chemical Properties]

white crystalline powder
[Uses]

Physiological coolant in foods, beverages, toiletries, cosmetics and pharmaceuticals.
[Definition]

ChEBI:Ethyl menthane carboxamide is a p-menthane monoterpenoid.
[Aroma threshold values]

Aroma characteristics at 1.0%. Virtually odorless
[Taste threshold values]

Taste characteristics at 10 to 100 ppm. Intense lingering cooling. The cooling sensation builds slow but steadily and grows to a lingering cooling mouthfeel with a slightly camphoraceous and minty character.
[Flammability and Explosibility]

Notclassified
[Trade name]

Winsense WS-3 (Renessenz)
[Biological Activity]

Cooling agent that is an agonist at TRPM8 receptors (EC 50 = 3.7 μ M).
[Synthesis]

0.89 g (0.0091 mol) of polyphosphoric acid (85%) and 0.42 g (0.0091 mol) of ethanol were weighed. 0.54 g (0.0046 mol) of diethylcarbonate was added dropwise slowly while cooling in an ice bath, wherein the temperature increases slightly. After about 5 minutes, 0.5 g (0.0030 mol) of p-menthane-3-carbonitrile was added. The reaction solution was heated and stirred for 102 hours at 150??C. At the end of the reaction by GC, about 70% of desired N-Ethyl-p-menthane-3-carboxamide was formed.Synthesis_39711-79-0Fig The synthetic method 1 of N-Ethyl-p-menthane-3-carboxamide
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

N-Ethyl-p-menthane-3-carboxamide(39711-79-0)MS
N-Ethyl-p-menthane-3-carboxamide(39711-79-0)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

N-Ethyl-p-menthane-3-carboxamide, 99%(39711-79-0)
[Sigma Aldrich]

39711-79-0(sigmaaldrich)
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