| Identification | More | [Name]
4-Methylthiazole-5-carboxaldehyde | [CAS]
82294-70-0 | [Synonyms]
4-METHYL-5-FORMYLTHIAZOLE
4-METHYL-5-THIAZOLECARBOXALDEHYDE
4-METHYL-5-THIAZOLYL ALDEHYDE
4-METHYLTHIAZOLE-5-ALDEHYDE
4-METHYL-THIAZOLE-5-CARBALDEHYDE
4-METHYLTHIAZOLE-5-CARBOXALDEHYDE
5-FORMYL-4-METHYLTHIAZOLE
5-THIAZOLECARBOXALDEHYDE4-METHYL
FMT
IFLAB-BB F2124-0219
5-Thiazolecarboxaldehyde, 4-methyl-(9CI)
4-methylthiazole-5-carboxaldehyde (intermediate of cefditoren pivoxil)
5-THIAZOLECARBOXALDEHYDE 4-METHYL 99+%
4-Methylthiazol-5-carboxaldehyde
4-methyl-5-thiazol carbaldehyde
4-Methyl-1,3-thiazole-5-carboxaldehyde
4-methyl-5-thiazole carboxaldchyde | [EINECS(EC#)]
617-314-4 | [Molecular Formula]
C5H5NOS | [MDL Number]
MFCD07368277 | [Molecular Weight]
127.16 | [MOL File]
82294-70-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
74-78 °C (lit.) | [Boiling point ]
118°C/21mmHg(lit.) | [density ]
1.270±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
1.53±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C5H5NOS/c1-4-5(2-7)8-3-6-4/h2-3H,1H3 | [InChIKey]
JJVIEMFQPALZOZ-UHFFFAOYSA-N | [SMILES]
S1C(C=O)=C(C)N=C1 | [LogP]
0.320 (est) | [CAS DataBase Reference]
82294-70-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H318 | [Precautionary statements ]
P280-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29341000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Uses]
4-Methylthiazole-5-carboxaldehyde is used as pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 4-methyl-5-thiazolecarboxaldehyde from 2-amino-4-methylthiazole-5-carboxaldehyde: A solution of tetrahydrofuran (THF, 3 mL) with amine 2 (5 mmol) was slowly added dropwise over a period of 20 min to a solution of tetrahydrofuran (THF, 3 mL) containing tert-butyl nitrite (t-BuONO, 7.5 mmol) and dimethylsulfoxide (DMSO, 0.5 mmol) in a solution of THF (7 mL). The reaction mixture was stirred continuously at 30°C until complete consumption of feedstock 2 was confirmed by thin layer chromatography (TLC) monitoring. Subsequently, the solvent was removed by evaporation and the yield of the low-boiling products was determined by gas chromatography (GC); the high-boiling products were separated and purified by silica gel column chromatography (eluent: hexane/ethyl acetate solvent mixture). | [References]
[1] Journal of Chemical Research, 2018, vol. 42, # 11, p. 579 - 583 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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