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Nifedipine Suppliers list
Company Name: Univar Solutions(China) Co., Ltd.
Tel: 15902132654
Products Intro: Product Name:Nifedipine
Purity:99.9% CP,USP,BP Package:25Kg/Drum;USD
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Products Intro: Product Name:Nifedipine
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:21829-25-4
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Products Intro: Product Name:Nifedipine
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Products Intro: Product Name:Nifedipine powder 21829-25-4
Purity:99% Package:1KG;10USD

Lastest Price from Nifedipine manufacturers

  • Nifedipine
  • US $0.00 / KG
  • 2020-10-23
  • CAS:21829-25-4
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Nifedipine
  • US $0.00 / Kg/Drum
  • 2020-06-04
  • CAS:21829-25-4
  • Min. Order: 25KG
  • Purity: 99.9% CP,USP,BP
  • Supply Ability: 10000000
  • Nifedipine
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:21829-25-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
Nifedipine Basic information
Pharmacological effects Chemical properties Uses Production methods Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Nifedipine
Synonyms:1,4-Dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl;Nifedipine,1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;Nifedipine (125 mg);Niter benzene horizontal;1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate;ALDIPIN ANIFED;ADALAT;ADALATE
Product Categories:Isotopically Labeled Pharmaceutical Reference Standard;CAPOTEN;Dihydropyridine;Pharmaceutical intermediate;Calcium channel;Intermediates & Fine Chemicals;Pharmaceuticals;Dihydropyridine Class Chemicals;Functional Materials;Photopolymerization Initiators;Pharmaceutical;Active Pharmaceutical Ingredients;Cardiovascular APIs;Cardiovascular Drugs;Ion Channels
Mol File:21829-25-4.mol
Nifedipine Structure
Nifedipine Chemical Properties
Melting point 171-175 °C
Boiling point 481.08°C (rough estimate)
density 1.2109 (rough estimate)
refractive index 1.5486 (estimate)
storage temp. 2-8°C
solubility DMSO: soluble
pkapKa -0.9/>13(DMF,t undefined) (Uncertain)
form powder
color yellow
Water Solubility <0.1 g/100 mL at 19.5 ºC
Merck 14,6528
CAS DataBase Reference21829-25-4(CAS DataBase Reference)
NIST Chemistry ReferenceNifedipine(21829-25-4)
EPA Substance Registry SystemDimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS US7975000
HazardClass IRRITANT
HS Code 29333990
ToxicityLD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)
MSDS Information
Nifedipine English
SigmaAldrich English
ACROS English
Nifedipine Usage And Synthesis
Pharmacological effectsNifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the Ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. Small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
Nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
The above information is edited by the chemicalbook of Tian Ye.
Chemical propertiesYellow crystals. Melting point 172-174 ℃. Soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. It easily deteriorates in case of light.
UsesLong-term coronary vasodilators. This product can increase coronary blood flow, reducing myocardial oxygen is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.
Production methodsO-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . The crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityOral-rat LD50: 1022 mg/kg; Oral-Mouse LD50: 310 mg/kg.
Flammability and hazard characteristicsCombustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.
Storage CharacteristicsVentilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.
Extinguishing agentDry powder, foam, sand, carbon dioxide, water spray.
Chemical PropertiesYellow Crystalline Solid
OriginatorAdalat,Bayer,W. Germany,1975
UsesUsed as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker
UsesFor the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
Manufacturing Process45 grams 2-nitrobenzaldehyde, 80 cc acetoacetic acid methyl ester, 75 cc methanol and 32 cc ammonia are heated under reflux for several hours, filtered off, cooled and, after suction-filtration, 75 grams of yellow crystals of MP 172° to 174°C are obtained, according to US Patent 3,485,847.
Brand nameAdalat (Bayer); Afeditab (Watson);Procardia (Pfizer).
Therapeutic FunctionCoronary vasodilator
World Health Organization (WHO)Nifedipine is a dihydropyridine calcium channel blocker. It is listed in the WHO Model List of Essential Drugs. The 10mg tablet is retained on the list for short-term treatment of hypertension. Sustained-release preparations are advised for long-term treatment.
General DescriptionNifedipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate dimethyl ester(Adalat, Procardia), is a dihydropyridine derivative thatbears no structural resemblance to the other calcium antagonists.It is not a nitrate, but its nitro group is essential for itsantianginal effect. As a class, the dihydropyridines possessa central pyridine ring that is partially saturated. To this, positions2 and 6 are substituted with an alkyl group that mayplay a role in the agent’s duration of action. In addition, positions3 and 5 are carboxylic groups that must be protectedwith an ester functional group. Depending on the type ofester used at these sites, the agent can be distributed to variousparts of the body. Finally, position 4 requires an aromaticsubstitution possessing an electron-withdrawinggroup (i.e., Cl or NO2) in the ortho and/or meta position.
General DescriptionOdorless yellow crystals or powder. Tasteless.
Air & Water ReactionsAqueous solutions are very sensitive to light. . Insoluble in water.
Reactivity ProfileNifedipine is sensitive to light.
Fire HazardFlash point data for Nifedipine are not available; however, Nifedipine is probably combustible.
Biological ActivityL-type calcium channel blocker.
Clinical UseThe prototype of this class, nifedipine, has potent peripheralvasodilatory properties. It inhibits the voltage-dependentcalcium channel in the vascular smooth muscle but has littleor no direct depressant effect on the SA or AV nodes, eventhough it inhibits calcium current in normal and isolated cardiactissues. Nifedipine is more effective in patients whoseanginal episodes are caused by coronary vasospasm and isused in the treatment of vasospastic angina as well as classicangina pectoris. Because of its strong vasodilatory properties,it is used in selected patients to treat hypertension.
Nifedipine Preparation Products And Raw materials
Raw materialsEthyl cyanoacetate-->Diethyl oxalate-->Benzaldehyde-->2-Nitrotoluene-->Methyl acetoacetate-->2-Nitrobenzaldehyde-->4-Aminobenzaldehyde-->Ammonia
Tag:Nifedipine(21829-25-4) Related Product Information
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