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Rosiglitazone maleate Produkt Beschreibung

Rosiglitazone maleate Struktur
155141-29-0
CAS-Nr.
155141-29-0
Englisch Name:
Rosiglitazone maleate
Synonyma:
Avandi;BRL-49653c;RSIGLITAZONEMALEATE;RosiglitazoneTartrate;ROSIGLITAZONE MALEATE;Rosiglitazone-d3 Maleate;Rosiglitazone Maleate forM;Rosiglitazone Maleate (200 mg);Rosiglitazone maleate USP/EP/BP;Rosiglitazone maleate Solution, 1000ppm
CBNumber:
CB0133276
Summenformel:
C22H23N3O7S
Molgewicht:
473.5
MOL-Datei:
155141-29-0.mol

Rosiglitazone maleate Eigenschaften

Schmelzpunkt:
235-240°C
storage temp. 
2-8°C
pka
6.1; 6.8(at 25℃)
Aggregatzustand
White powder
InChIKey
HCDYSWMAMRPMST-NTCAYCPXSA-N
CAS Datenbank
155141-29-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 20/21/22-36/38
S-Sätze: 24/25-37/39-26
WGK Germany  3

Rosiglitazone maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues. The racemic base can be obtained by KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding 4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine), followed by reduction of the benzylidene. Rosiglitazone was shown to be a potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma), a nuclear receptor involved in the differentiation of adipose tissue, without activating liver PPAR-alpha receptors. This activation of PPAR-gamma could mediate the down-regulation of leptin gene expression. In animal models, Rosiglitazone has been shown to normalize glucose metabolism and reduce the exogenous dose of insulin needed to achieve glycemic control. In patients with Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved blood sugar control without affecting cardiac structure or function.

Chemische Eigenschaften

White To Off-White Solid

Originator

SmithKline Beecham (US)

Verwenden

Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).

Verwenden

Thiazole alkanes antidiabetic drug

Verwenden

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD that has served as a reference compound for this class. It is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of type 2 diabetes in humans for many years.[Cayman Chemical]

Indications

Rosiglitazone maleate is an antihyperglycemic agent in the thiazolidinedione class. It is indicated for the treatment of patients with type 2 diabetes mellitus.

Trademarks

Avandia (GlaxoSmithKline).

Rosiglitazone maleate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rosiglitazone maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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155141-29-0()Verwandte Suche:


  • 5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE
  • 5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate
  • ROSIGLITAZONE MALEATE
  • RosiglitazoneTartrate
  • Avandi
  • BRL-49653c
  • RSIGLITAZONEMALEATE
  • 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate
  • Rosiglitazone Maleate (200 mg)
  • 5-[[4-[2-(Methyl-2-pyridinylaMino)ethoxy]phenyl]Methyl]-2,4-thiazolidinedione (2Z)-2-Butenedioate
  • Rosiglitazone Maleate forM
  • Rosiglitazone-d3 Maleate
  • 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione,(2Z)-2-butenedioate (1:1)
  • 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate salt
  • 5-[[4-[2-[methyl(2-pyridinyl)amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • Rosiglitazone maleate Solution, 1000ppm
  • 2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-, (2Z)-2-butenedioate (1:1)
  • Rosiglitazone maleate USP/EP/BP
  • 155141-29-0
  • C18H19N3O3SC4H4O4C22H23N3O7S
  • C18H19N3O3SC4H4O4C
  • C18H19N3O3SoC4H4O4
  • C18H19N3O3SC4H4O4
  • C22H23N3O7S
  • API
  • Inhibitor
  • Antidiabetic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API's
  • Rosiglitazone
  • Heterocycles
  • Sulfur & Selenium Compounds
  • Active Pharmaceutical Ingredients
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