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Rosiglitazone maleate Produkt Beschreibung

CAS-Nr.155141-29-0
Bezeichnung:
Englisch Name:Rosiglitazone maleate
Synonyma:
Avandi;BRL-49653c;RSIGLITAZONEMALEATE;RosiglitazoneTartrate;ROSIGLITAZONE MALEATE;Rosiglitazone-d3 Maleate;Rosiglitazone Maleate forM;Rosiglitazone Maleate (200 mg);Rosiglitazone maleate Solution, 1000ppm;5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate
CBNumber:CB0133276
Summenformel:C22H23N3O7S
Molgewicht:473.5
MOL-Datei:155141-29-0.mol
Rosiglitazone maleate physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 235-240°C
storage temp. : -20°C Freezer
pka: 6.1; 6.8(at 25℃)
Aggregatzustand: White powder
CAS Datenbank: 155141-29-0(CAS DataBase Reference)
Sicherheit
Kennzeichnung gefährlicher: Xi
R-Sätze:: 20/21/22-36/38
S-Sätze:: 24/25-37/39-26
WGK Germany : 3

Rosiglitazone maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Rosiglitazone maleate, belongs to a novel class of thiazolidine diones launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), a disease characterized by a pancreatic β-cell defect and insulin resistance in the liver and peripheral tissues. The racemic base can be obtained by KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding 4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine), followed by reduction of the benzylidene. Rosiglitazone was shown to be a potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma), a nuclear receptor involved in the differentiation of adipose tissue, without activating liver PPAR-alpha receptors. This activation of PPAR-gamma could mediate the down-regulation of leptin gene expression. In animal models, Rosiglitazone has been shown to normalize glucose metabolism and reduce the exogenous dose of insulin needed to achieve glycemic control. In patients with Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved blood sugar control without affecting cardiac structure or function.
Chemische Eigenschaften
White To Off-White Solid
Originator
SmithKline Beecham (US)
Verwenden
Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ).
Verwenden
Thiazole alkanes antidiabetic drug
Verwenden
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD that has served as a reference compound for this class. It is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of type 2 diabetes in humans for many years.[Cayman Chemical]
Trademarks
Avandia (GlaxoSmithKline).
Rosiglitazone maleate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rosiglitazone maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 206)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Mainchem Co., Ltd.
+86-0592-6210733
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Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6402 58
Chemwill Asia Co.,Ltd.
86-21-51086038
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Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20177 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409orders@qcchemical.com United States 8416 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19975 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519sales@RHFChem.com China 2359 56
Secco work (Beijing) chemical technology co., LTD 010-69755668;
010-697556681139670422@qq.com China 3609 54
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595sales@chemreagents.com United States 9937 62
 
155141-29-0(Rosiglitazone maleate)Verwandte Suche:
Maleinsäure (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-prolinmaleat 1-(2-Oxo-2-pyrrolidin-1-ylethyl)-4-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperazinmonomaleat Benzylisocyanat Thiazolidin-2,4-dion Ethoxychin Ethylethinylether O-Ethylhydroxylaminhydrochlorid Benzyl [2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammoniumhydrogenmaleat Ethoxy Rosiglitazone Benzylchlorid Benzylbenzoat Benzylalkohol Diethoxymethan Rosiglitazone hydrochloride Ethoxymethylenmalononitril
5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE 5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate ROSIGLITAZONE MALEATE RosiglitazoneTartrate Avandi BRL-49653c RSIGLITAZONEMALEATE 5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate Rosiglitazone Maleate (200 mg) 5-[[4-[2-(Methyl-2-pyridinylaMino)ethoxy]phenyl]Methyl]-2,4-thiazolidinedione (2Z)-2-Butenedioate Rosiglitazone Maleate forM 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione,(2Z)-2-butenedioate (1:1) 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione maleate salt 5-[[4-[2-[methyl(2-pyridinyl)amino]ethoxy]phenyl]methyl]thiazolidine-2,4-dione Rosiglitazone-d3 Maleate 155141-29-0 C18H19N3O3SC4H4O4 C22H23N3O7S C18H19N3O3SC4H4O4C22H23N3O7S C18H19N3O3SoC4H4O4 C18H19N3O3SC4H4O4C Active Pharmaceutical Ingredients Antidiabetic Intermediates & Fine Chemicals Pharmaceuticals API's Rosiglitazone Heterocycles Sulfur & Selenium Compounds Inhibitor API Rosiglitazone maleate Solution, 1000ppm
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