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Benzylbenzoat Produkt Beschreibung

Benzyl benzoate Struktur
120-51-4
CAS-Nr.
120-51-4
Bezeichnung:
Benzylbenzoat
Englisch Name:
Benzyl benzoate
Synonyma:
Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox;Scobenol
CBNumber:
CB9152283
Summenformel:
C14H12O2
Molgewicht:
212.24
MOL-Datei:
120-51-4.mol

Benzylbenzoat Eigenschaften

Schmelzpunkt:
18 °C
Siedepunkt:
323-324 °C(lit.)
Dichte
1.118 g/mL at 20 °C(lit.)
Dampfdruck
1 mm Hg ( 125 °C)
Brechungsindex
n20/D 1.568(lit.)
FEMA 
2138 | BENZYL BENZOATE
FEMA 
2797 | OCTANAL
Flammpunkt:
298 °F
storage temp. 
2-8°C
Löslichkeit
Miscible with ethanol, alcohol, chloroform, ether, oils.
Aggregatzustand
Liquid
Farbe
Clear colorless
Wasserlöslichkeit
practically insoluble
Merck 
14,1127
JECFA Number
24
BRN 
2049280
Stabilität:
Stable. Substances to be avoided include strong oxidizing agents. Combustible.
InChIKey
SESFRYSPDFLNCH-UHFFFAOYSA-N
CAS Datenbank
120-51-4(CAS DataBase Reference)
NIST chemische Informationen
Benzyl Benzoate(120-51-4)
EPA chemische Informationen
Benzoic acid, phenylmethyl ester(120-51-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 22-51/53
S-Sätze: 25-61-46
RIDADR  UN 3082 9 / PGIII
WGK Germany  2
RTECS-Nr. DG4200000
Selbstentzündungstemperatur 896 °F
TSCA  Yes
HazardClass  9
HS Code  29163100
Giftige Stoffe Daten 120-51-4(Hazardous Substances Data)
Toxizität LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P273 Freisetzung in die Umwelt vermeiden.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Benzylbenzoat Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE FLüSSIGKEIT ODER WEISSER FESTSTOFF MIT CHARAKTERISTISCHEM GERUCH.

PHYSIKALISCHE GEFAHREN

Die Dämpfe sind schwerer als Luft.

CHEMISCHE GEFAHREN

Beim Verbrennen Bildung giftiger und reizender Rauche.

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

INHALATIONSGEFAHREN

Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atemwege.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen.

LECKAGE

Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S25:Berührung mit den Augen vermeiden.

Beschreibung

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

Chemische Eigenschaften

Benzyl benzoate is a clear, colorless, oily liquid with a slightly aromatic odor. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals.

Chemische Eigenschaften

Benzyl benzoate has a light, balsamic odor reminiscent of almond and a sharp, pungent taste.

Chemische Eigenschaften

Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor. It is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

Chemische Eigenschaften

Colourless oily liquid with pleasant aromatic odour

Occurrence

Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).

Verwenden

Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
a fixative in fragrances to improve the stability and other characteristics of the main ingredients
a food additive in artificial flavors
a plasticizer in cellulose and other polymers
a solvent for various chemical reactions
a treatment for sweet itch in horses
a treatment for scaly leg mites in chickens.

Verwenden

antiarteriosclerotic, hypolipaemic, hepatoprotectant

Verwenden

Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.

Verwenden

Used to kill lice and the mites responsible for the skin condition scabies.

Verwenden

As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

Verwenden

benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

Vorbereitung Methode

Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde.

synthetische

By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

Trademarks

Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).

Taste threshold values

Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

Hazard

Irritant to eyes, skin.

Pharmazeutische Anwendungen

Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.

Kontakt-Allergie

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

Clinical Use

Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.

Sicherheit(Safety)

Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
LD50 (cat, oral): 2.24 g/kg
LD50 (dog, oral): 22.44 g/kg
LD50 (guinea pig, oral): 1.0 g/kg
LD50 (mouse, oral): 1.4 g/kg
LD50 (rabbit, oral): 1.68 g/kg
LD50 (rabbit, skin): 4.0 g/kg
LD50 (rat, oral): 0.5 g/kg
LD50 (rat, skin): 4.0 g/kg

Chemical Synthesis

This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

Lager

Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.

Inkompatibilitäten

Benzyl benzoate is incompatible with alkalis and oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Benzylbenzoat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Benzylbenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 358)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 913 58
Hebei Chisure Biotechnology Co., Ltd.
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0311 66567340 luna@speedgainpharma.com CHINA 1017 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
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Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 210 58

120-51-4(Benzylbenzoat)Verwandte Suche:


  • N-tert-Butoxycarbonyl-L-aspartic Acid &alpha
  • Benzyl benzoate ReagentPlus(R), >=99.0%
  • Benzyl benzoate Vetec(TM) reagent grade, 98%
  • Benzoic acid benzyl ester≥ 99% (GC)
  • VANZOATE(R)
  • VENZONATE(R)
  • Benylate
  • Benzyl alcohol benzoic ester
  • Benzyl ester
  • benzylalcoholbenzoicester
  • Benzylester kyseliny benzoove
  • ASCABIN
  • ASCABIOL
  • ASCABIOL(R)
  • BENZOATO DE BENCILO
  • Benzyl benzoate 99+ %
  • Phenylmethyl benzoate
  • BENZYL BENZOATE, 1GM, NEAT
  • BENZYL BENZOATE 99+% FCC
  • BENZYL BENZOATE 99+% NATURAL FCC
  • BENZYL BENZOATE, USP
  • BENZYL BENZOATE, PH EUR
  • Benzyl Benzoate PQ
  • BENZYL BENZOATE, PHARMA
  • benzylbenzoate,phenylmethylbenzoate
  • Benzylbenzoat
  • Benzyl Benoate
  • Benryl benzoate
  • spasmodin
  • Benzile benzoate
  • BENZYL BENZOATE, NATURAL
  • Benzyl benzoate, EP, BP, USP
  • Benzoic acid benzyl ester, Benzylis benzoas
  • benzyl benzonate
  • Z-D-glutamic acid &gamma
  • Boc-N-methyl-L-glutamic acid &gamma
  • N-Boc-L-glutamic Acid &alpha
  • Boc-DL-glutamic acid &gamma
  • benzylesterkyselinybenzoove
  • Benzylets
  • Colebenz
  • femanumber2138
  • Novoscabin
  • Peruscabin
  • Phenylmethyl (benzyl) ester
  • Scabagen
  • Scabanca
  • Scabide
  • Scabiozon
  • Scabitox
  • Scobenol
  • Vanzoate
  • Venzoate
  • Venzonate
  • FEMA 2138
  • BENZOIC ACID BENZYL ESTER
  • BENZOIC ACID PHENYLMETHYL ESTER
  • BENZYL BENZENECARBOXYLATE
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