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Dexamethasone 21-phosphate disodium salt Produkt Beschreibung

Dexamethasone 21-phosphate disodium salt Struktur
2392-39-4
CAS-Nr.
2392-39-4
Englisch Name:
Dexamethasone 21-phosphate disodium salt
Synonyma:
Ak-Dex;Baldex;Decdan;dexagro;Dexagel;Dalalone;Dexabene;megacort;soldesam;Colvasone
CBNumber:
CB0153737
Summenformel:
C22H28FNa2O8P
Molgewicht:
516.4
MOL-Datei:
2392-39-4.mol

Dexamethasone 21-phosphate disodium salt Eigenschaften

Schmelzpunkt:
233-235 °C
alpha 
D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
storage temp. 
2-8°C
Löslichkeit
H2O: 50 mg/mL, clear, faintly yellow
Aggregatzustand
White Powder
Farbe
white to off-white
PH
pH(10g/l, 25℃) : 7.5~10.5
Wasserlöslichkeit
Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Merck 
13,2960
BRN 
6473066
InChIKey
PLCQGRYPOISRTQ-FCJDYXGNSA-L
CAS Datenbank
2392-39-4(CAS DataBase Reference)
EPA chemische Informationen
Dexamethasone disodium phosphate (2392-39-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-40-63
S-Sätze: 36/37/39
WGK Germany  3
RTECS-Nr. TU4056000
3-10
TSCA  Yes
HS Code  2937220000
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Dexamethasone 21-phosphate disodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

White or almost white, very hygroscopic powder.

Originator

Decadron Phosphate,MS and D,US,1959

Verwenden

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

Verwenden

Dexamethasone-21-phosphate disodium salt is used in eye and ear preparations and in systemic preparations.

Verwenden

glucocorticoid, antiinflammatory

Definition

ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

Trademarks

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Sicherheitsprofil

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F-, PO,, and Na2O.

Dexamethasone 21-phosphate disodium salt Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dexamethasone 21-phosphate disodium salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 386)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
APOLLO HEALTHCARE RESOURCES
+6596580999
sales@apollo-healthcare.com.sg Singapore 312 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15426 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

2392-39-4()Verwandte Suche:


  • decadronphosphate
  • dexadreson
  • dexagro
  • dexamethasonedisodiumphosphate
  • disodiumdexamethasonephosphate
  • disodiumsalt,(11beta,16alpha)-y)
  • DEXAMETHASONE 21-PHOSPHATE DISODIUM SALT
  • DEXAMETHASONE PHOSPHATE DISODIUM SALT
  • DEXAMETHASONE PHOSPHATE SODIUM
  • DEXAMETHASON SODIUM PHOSPHATE
  • dexamethasone 21-(disodium phosphate)
  • DEXAMETHASONE SODIM PHOSPHATE
  • Dexamethasone acetate phosphate
  • DEXAMETHASONE 21-PHOSPHATE DISODIUM
  • DEXAMETHASONE SODIUM PHOSPHATE BP STANDARD(CRM STANDARD)
  • DEXAMETHASONE SODIUM PHOSPHATE BP(CRM STANDARD)
  • DEXAMETHASONE SODIUM PHOSPHATE EPD(CRM STANDARD)
  • DEXAMETHASONE SODIUM PHOSPHATE MM(CRM STANDARD)
  • DEXAMETHASONE SODIUM PHOSPHATE WHO(CRM STANDARD)
  • DexamethasoneSodiumPhosphateBp
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.alpha.)-
  • DEXAMETHASONESODIUMPHOSPHATE,POWDER,USP
  • Ak-Dex
  • Baldex
  • Colvasone
  • Corson (pharmaceutical)
  • Dalalone
  • Decdan
  • Dexabene
  • Dexagel
  • Dexamethasone phosphate sodium salt
  • Dexamethazone sodium phosphate
  • Disodium dexamethasone 21-monophosphate
  • Disodium dexamethasone 21-phosphate
  • Maxidex Ointment
  • Orgadrone
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11β,16α)-
  • Dexamethasone sodium phosphate for peak identification
  • Dexamethasone 21-Phosphate Disodium Salt Hydrate
  • Dexamethasone Sodium Phosphate (350 mg)
  • Dexamethasone 21-phosphate disodium salt, >=98%
  • 9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt
  • C22H28FNa208P
  • 21-Phosphate disodium salt
  • 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate
  • Dexamethasone Phosphate disodium
  • megacort
  • pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonoox
  • sodiumdexamethasonephosphate
  • soldesam
  • solu-decadron
  • spersadox
  • 9α-Fluoro-16α-methyl-3,20-dioxo-1,4-pregnadiene-11β,17α,21-triol 21-(phosphoric acid disodium) salt
  • Phosphoric acid 9α-fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxo-1,4-pregnadien-21-yldisodium salt
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate) disodium salt (8CI)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate disodium salt (6CI)
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