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Ampicillin Produkt Beschreibung

Ampicillin Struktur
69-53-4
CAS-Nr.
69-53-4
Bezeichnung:
Ampicillin
Englisch Name:
Ampicillin
Synonyma:
p-50;Wymox;ab-pc;Unasyn;qidamp;Albipen;amfipen;ampicin;ampimed;ay-6108
CBNumber:
CB2247346
Summenformel:
C16H19N3O4S
Molgewicht:
349.41
MOL-Datei:
69-53-4.mol

Ampicillin Eigenschaften

Schmelzpunkt:
198-200 °C (dec.)(lit.)
alpha 
D23 +287.9° (c = 1 in water)
Siedepunkt:
201.8°C (rough estimate)
Dichte
1.2794 (rough estimate)
Brechungsindex
1.6320 (estimate)
storage temp. 
2-8°C
Löslichkeit
NH4OH 1 M: 50 mg/mL, clear, colorless
Aggregatzustand
solid
pka
2.5 (COOH)(at 25℃)
JECFA Number
85
Merck 
13,591
BRN 
1090925
Stabilität:
Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents.
InChIKey
AVKUERGKIZMTKX-NJBDSQKTSA-N
CAS Datenbank
69-53-4(CAS DataBase Reference)
EPA chemische Informationen
Ampicillin (69-53-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T
R-Sätze: 36/37/38-42/43-61
S-Sätze: 22-26-36/37-45-53
WGK Germany  2
RTECS-Nr. XH8425000
10-23
HS Code  29212900
Giftige Stoffe Daten 69-53-4(Hazardous Substances Data)
Toxizität LD50 oral in mouse: > 5gm/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P333+P313 Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.

Ampicillin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria.
Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.
Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.

Chemische Eigenschaften

Crystalline Solid

Chemische Eigenschaften

Ampicillin in anhydrous form occurs as crystals.

Verwenden

β-lactam antibiotics

Verwenden

Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.

Trademarks

Amcill (Parke-Davis); Omnipen (Wyeth-Ayerst); Polycillin (Apothecon); Principen (Apothecon).

Kontakt-Allergie

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Sicherheitsprofil

Poison by intracerebral route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: fever, agranulocytosis, and other blood effects. An experimental teratogen. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NO, and SOx,.

mögliche Exposition

Used as an antibiotic.

Veterinary Drugs and Treatments

In dogs and cats, ampicillin is not as well absorbed after oral administration as amoxicillin and its oral use has largely been supplanted by amoxicillin. It is used commonly in parenteral dosage forms when an aminopenicillin is indicated in all species.
The aminopenicillins, also called the “broad-spectrum” or ampicillin penicillins, have increased activity against many strains of gram-negative aerobes not covered by either the natural penicillins or penicillinase-resistant penicillins, including some strains of E. coli, Klebsiella, and Haemophilus.

Versand/Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Inkompatibilitäten

May be incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Ampicillin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ampicillin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 238)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22633 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 570 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29995 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23981 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58

69-53-4(Ampicillin)Verwandte Suche:


  • Sultamicillin EP Impurity C (Ampicillin, Piperacillin EP Impurity A)
  • 99% Ampicillin 69-53-4 Pharmaceutical Raw Material Manufacturer
  • Piperacillin Impurity 1(EP Impurity A)
  • 6-[D-ALPHA-AMINOPHENYLACETAMIDO]PENICILLANIC ACID TRIHYDRATE
  • ALPHA-AMINOBENZYLPENICILLIN, TRIHYDRATE
  • D(-)-ALPHA-AMINOBENZYLPENICILLIN
  • D(-)-ALPHA-AMINOBENZYLPENICILLIN TRIHYDRATE
  • D(-)-aplha-aminobenzylpenicillin
  • Marisilan
  • Penstabil
  • Rosampline
  • Unasyn
  • Wymox
  • Ampicilin Trihydrate
  • AMPICILLIN ANHYDROUS CRYSTALLINE
  • AMPICILLIN READY MADE SOLUTION
  • AMPICILLIN, ANHYDROUS MM(CRM STANDARD)
  • Ampicillinbase
  • AMPICILIN 3-HYDRATE
  • 6-(D-[-]-α-Aminophenylacetamido) penicillanic acid
  • 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-aminophenylacetylamino-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
  • (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Ampicillin
  • (2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3,3-dimethyl-7 -oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
  • Albipen
  • Ampicillin-d5 (Mixture of Diastereomers)
  • 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylic acid trihydrate
  • ampicillin soluble powder70%
  • Nonane-1,9-diamine
  • Aminobenzylpenicillin/sulbactam
  • Ampicillin/Sulbactam,(1:x)
  • SBT/ABPC
  • Sultamicillin Impurity 3(Sultamicillin EP Impurity C)
  • (aminophenylmethyl)-penicilli
  • [2s-[2alpha,5alpha,6beta(s)]]-o]-3-dimethyl-7-oxo
  • 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[(aminophenylacetyl)amin
  • 6-(d(-)-alpha-aminophenylacetamido)penicillanicacid
  • 6-[d(-)-alpha-aminophenylacetamido]penicillanicacid
  • 6-[d-(2-amino-2-phenylacetamido)]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0
  • ab-pc
  • adobacillin
  • amblosin
  • amfipen
  • aminobenzylpenicillin
  • amipenixs
  • ampi-bol
  • ampicillina
  • ampicillinacid
  • ampicillinanhydrate
  • ampicillinanhydrous
  • ampicin
  • ampimed
  • ampipenin
  • amplisom
  • amplital
  • ampy-penyl
  • austrapen
  • ay-6108
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