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Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat Produkt Beschreibung

Potassium clavulanate Struktur
61177-45-5
CAS-Nr.
61177-45-5
Bezeichnung:
Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat
Englisch Name:
Potassium clavulanate
Synonyma:
MM 1415;Amonate;brl14151k;Clavulanate;Clavulanate K;Potassium Clavulanat;CLAVULANTE POTASSIUM;CLAVULANIC POTASSIUM;CLAVULANATE POTASSIUM;potassium calvulanate
CBNumber:
CB2722502
Summenformel:
C8H10KNO5
Molgewicht:
239.27
MOL-Datei:
61177-45-5.mol

Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat Eigenschaften

Schmelzpunkt:
>1600C (dec)
alpha 
+55~+60°
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
Aggregatzustand
neat
InChIKey
ABVRVIZBZKUTMK-JSYANWSFSA-M
CAS Datenbank
61177-45-5(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,Xn,Xi
R-Sätze: 11-42/43-44-36-14
S-Sätze: 8-16-22-36/37-45-43-26
RIDADR  UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany  2
RTECS-Nr. RN6802700
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H228 Entzündbarer Feststoff. Entzündbare Feststoffe Kategorie 1 Achtung
Warnung
P210, P240,P241, P280, P370+P378
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Pale Yellowish Solid

Originator

Clavulanate ,potassium Lek

Verwenden

A -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness

Verwenden

Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Verwenden

Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.

Definition

ChEBI: A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases.

Manufacturing Process

Clavulanic acid may be obtained by aerobic cultivation of Streptomyces clavuligerus in conventional nutrient media at, for example, about 25°-30°C under roughly neutral conditions.
Cultivation of Streptomyces clavuligeru: Streptomyces clavuligerus was cultivated at 26°C on agar slopes containing 1% Yeatex (yeast extract) ("Yeatex" is a Registered Trade mark), 1% glucose and 2% Oxoid agar No. 3, pH 6.8. A sterile loop was used to transfer mycelium and spores from the slope into 100 ml of a liquid medium in a 500 ml Ehrlenmeyer flask. The liquid medium had the following composition: Oxoid Malt Extract 10g/L, Oxoid Bacteriological Peptone 10g/L, Glycerol 20 g/L, Tap water 1 L.
The medium was adjusted to pH 7.0 with sodium hydroxide solution and 100 ml volumes dispensed into flasks which were closed with foam plugs prior to autoclaving at 15 lb/sq.in. for 20 min. An inoculated seed flask was shaken for 3 days at 26°C on a rotary shaker with a 2 inch throw and a speed of 240 r.p.m.
Production stage flasks containing the liquid medium described above were inoculated with 5% vegetative inoculum and grown under the same conditions as the seed flask.
Clavulanic acid may be extracted from the culture medium. Normally the cells of the Streptomyces clavuligerus are first removed from culture medium by filtration or centrifugation. Then clavulanic acid is extracted into an organic solvent, for example, n-butanol or ethyl acetate, or n-butyl acetate, or methyl isobutyl ketone. Then n-butanol fraction are treated with new aqueous phase using potassium hydrogen carbonate and then this aqueous phase is washed with n-butanol. This aqueous extract, after separation of the phases, is concentrated under reduced pressure. Freeze-drying at -20°C may also be
employed to provide a solid crude preparation of the potassium Z-(2R,5R)-3- (β-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3,2,0]heptane-2-carboxylate (clavulanate potassium).

Therapeutic Function

Beta-lactamase inhibitor

Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 220)Lieferanten
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Jinan Shengqi pharmaceutical Co,Ltd
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
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Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
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02783214688 bruce@xrdchem.cn CHINA 567 55
ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5478 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58

61177-45-5(Kalium-[2R-(2α,3Z,5α)]-3-(2-hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-2-carboxylat)Verwandte Suche:


  • CLAVULANATE POTASSIUM
  • CLAVULANIC ACID POTASSIUM
  • CLAVULANIC ACID POTASSIUM SALT
  • CLAVULANTE POTASSIUM
  • MM 1415
  • Potassium Clavulanat
  • Clavulanate
  • 4-Oxa-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-
  • POTASSIUMCLAVULANATE,EP
  • 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)- (9CI)
  • 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2a,3Z,5a)]-
  • potassium calvulanate
  • clavulanate,potassium salt
  • CLAVULANIC ACID POTASSIUM SALT (POTASSIUM CLAVULANATE)/AVICEL (1:1)
  • Clavulanate K
  • Clavulanic acid potassium salt (Potassium Clavulanate)/Avicel (1
  • Clavulanate:Cellulose
  • Clavulanic acid Potassium salt:Cellulose (1:1)
  • Clavulanate PotassiuMAvicel API
  • CLAVULANATE POTASSIUM +AVICE
  • potassiuM (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • ClavubactaM potassiuM, BRL 14151
  • Clavullinate PotassiuM USP
  • Microcrystalline cellulose (1:1)
  • potassium clavulanate sterile
  • Amonate
  • POTASSIUM CLAVULANATE
  • potassium (z)-(2r,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • brl14151k
  • monopotassiumsalt,(2r-(2-alpha,3z,5-alpha))-xo
  • CLAVULANIC POTASSIUM
  • potassium [2R-(2alpha,3Z,5alpha)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • POTASSIUM CLAVULANATE FROM STREPTOMYCES
  • 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-
  • Clavaulanate Potassium with Microcrystalline Cellulose 1:1
  • Amoxicillin with Clavulanate Potassium 4:1
  • Trihydrate with Clavanate Potassium 4:1
  • Potassium Clavulanate Standard
  • Potassium clavulanate USP/EP/BP
  • 61177-45-5
  • C8H8NO5K
  • C8H8KNO5
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