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Potassium clavulanate

Description Uses Cautions Administration Side Effects
Potassium clavulanate
Potassium clavulanate
CAS No.
61177-45-5
Chemical Name:
Potassium clavulanate
Synonyms
MM 1415;brl14151k;Clavulanate;Clavulanate K;CLAVULANIC POTASSIUM;CLAVULANTE POTASSIUM;Potassium Clavulanat;CLAVULANATE POTASSIUM;POTASSIUM CLAVULANATE;potassium calvulanate
CBNumber:
CB2722502
Molecular Formula:
C8H8KNO5
Formula Weight:
237.25
MOL File:
61177-45-5.mol

Potassium clavulanate Properties

Melting point:
>1600C (dec)
storage temp. 
2-8°C
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
form 
neat
InChIKey
ABVRVIZBZKUTMK-JSYANWSFSA-M
CAS DataBase Reference
61177-45-5(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn,Xi
Risk Statements  11-42/43-44-36-14
Safety Statements  8-16-22-36/37-45-43-26
RIDADR  UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany  2
RTECS  RN6802700
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H228 Flammable solid Flammable solids Category 1
Category 2
Danger
Warning
P210, P240,P241, P280, P370+P378
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Potassium clavulanate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33454 Potassium clavulanate VETRANAL 61177-45-5 100mg $143 2018-11-20 Buy
Cayman Chemical 19456 Clavulanate (potassium salt) ≥95% 61177-45-5 5mg $19 2018-11-19 Buy
Cayman Chemical 19456 Clavulanate (potassium salt) ≥95% 61177-45-5 10mg $34 2018-11-19 Buy
Cayman Chemical 19456 Clavulanate (potassium salt) ≥95% 61177-45-5 25mg $52 2018-11-19 Buy
Cayman Chemical 19456 Clavulanate (potassium salt) ≥95% 61177-45-5 50mg $70 2018-11-19 Buy

Potassium clavulanate Chemical Properties,Uses,Production

Description

Potassium clavulanate is a semi-synthetic beta-lactamase inhibitor isolated from Streptomyces. The compound contains a beta-lactam ring and strongly binds to beta-lactamase at their new active site, which protects other beta-lactam antibiotics such as amoxicillin from beta-lactamase catalysis.

Uses

Combination of potassium clavulanate and amoxicillin is normally used in medicine to treat numerous different infections caused by bacteria, for instance, pneumonia, sinusitis, ear infections, urinary tract infections, bronchitis, and skin infections. Potassium clavulanate can also combined with other penicillin-based antibiotics.

Cautions

Before taking a combination of potassium clavulanate with any other penicillin-based antibiotic, one should discuss with medical providers and let them know whether they have severe kidney disease, jaundice or liver problems. In addition, it is important to inform the physician if an individual is allergic to penicillin or cephalosporin antibiotic, such as Amoxil, Levaquin, omnicef, and cefzil.

Although it is not clear with this drug may harm an unborn baby, it is important to inform the physician if one is pregnant or intending to become pregnant. In addition, studies have indicated that pass into breast milk, thus may affect a nursing infant. As such, it is important to inform the doctor if one is breast-feeding. Children should never be given potassium clavulanate without consulting a physician.

Administration

The drug should be take according to the prescription given by the doctor. Potassium clavulanate is taken orally every 12 hours at the start of a meal to minimize side effects such as stomach upset.

The extended release of the potassium clavulanate tablet must never been chewed or crushed. The medicine should be swallowed as a whole while the chewable tablet must be chewed before swallowing it. Before measuring a dose, the liquid medicine must be shaken well. The medicine should be only used for the full length of prescribed time. It is important not to skip any doses as it may lead to further infection that is resistant to antibiotics.

The medicine should never be taken with or just after ingesting a high-fat meal as it will make it harder for the body to absorb the drug.

Side Effects

Potassium clavulanate may cause diarrhea that is bloody or watery when taken in combination with amoxicillin. It may also lead to severe stomach pain, swelling of the face or tongue, loss of appetite, fever, dark color urine, weakness, or confusion. The medicine may cause jaundice or yellowing of skin as well as vaginal itching or discharge.

Chemical Properties

Pale Yellowish Solid

Uses

Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Uses

Clavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.

Uses

A -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness

Definition

ChEBI: A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases.

Potassium clavulanate Preparation Products And Raw materials

Raw materials

Preparation Products


Potassium clavulanate Suppliers

Global( 136)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22060 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14297 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
UHN Shanghai Research & Development Co., Ltd. +86 (21) 5895-8002
+86 (21) 5895-8628 sales@uhnshanghai.com China 1039 58
Wuhan Runzeweiye Technology Co., Ltd. 027-50779735 15172337137 QQ:940329747
027-50779735 runzeweiye999@163.com China 803 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Potassium clavulanate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-13 Potassium clavulanate
61177-45-5
US $210.00 / KG 1KG 97% 1000KG career henan chemical co

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