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6-Gingerol

6-Gingerol Struktur
23513-14-6
CAS-Nr.
23513-14-6
Englisch Name:
6-Gingerol
Synonyma:
GINGEROL;Gingerols;rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one;6-GINGEROL;GINGEROL [6];(s)-3-decanon;6-Gingerol ,98%;6-Gingerol std.;[6]-Gingerol>(s)-(6)-gingerol
CBNumber:
CB4328683
Summenformel:
C17H26O4
Molgewicht:
294.39
MOL-Datei:
23513-14-6.mol
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6-Gingerol Eigenschaften

Schmelzpunkt:
31℃
Siedepunkt:
453.0±35.0 °C(Predicted)
Dichte
1.083±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
methanol: soluble1mg/mL, clear, colorless
Aggregatzustand
Pale yellow oil
pka
10.02±0.20(Predicted)
Farbe
White to Light yellow
InChI
InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
InChIKey
NLDDIKRKFXEWBK-AWEZNQCLSA-N
SMILES
C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC
LogP
2.485 (est)
CAS Datenbank
23513-14-6(CAS DataBase Reference)
NIST chemische Informationen
Gingerol(23513-14-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38
S-Sätze: 26-36/37
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS-Nr. HE0757000
HS Code  29145090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

6-Gingerol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Light yellow ceraceous solid

Verwenden

[6]-Gingerol has been used:
  • to study its effects on transient receptor potential (TRP) channels
  • to study its effects on experimental models of non-alcoholic steatohepatitis
  • to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
  • to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice

Definition

ChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.

Allgemeine Beschreibung

6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.

Anticancer Research

6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, whichshowed antioxidant, anti-inflammation, and antitumor properties. It has the capacityto inhibit NOS, TNF-α, and COX-2 enzymes which are regulated by NF-κB(Aggarwal and Shishodia 2004; Wang et al. 2012). It hinders the cell growth ofprostate, gastric, and breast cancer cells and suppresses the lung metastasis ofB16F10 melanoma. It exhibits antitumorigenic effect in human colorectal cancercells via upregulating NSAID-activated gene-1 (NAG-1) (Aggarwal et al. 2008). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner (Singh et al. 2016b). ROS levels were significantlyincreased in K562 and MOLT4 cells treated with gingerol, and apoptosis wasinduced in leukemia cells by mitochondrial pathway (Wang et al. 2012).

6-Gingerol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-Gingerol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 386)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +8618374838656
 sales@staherb.cn China 1025 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651
 admin@zlchemi.com China 476 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9348 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083
 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897
 sales@biopurify.com China 3424 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58

23513-14-6()Verwandte Suche:

Anisol Diphenylsilandiol p-Anissure 3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure Anisaldehyd Phenylvalerat 4-Methoxy-anilin 4-Methoxyphenylaceton Cianidanol (Trifluormethoxy)benzol 2-(3,4-Dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromen PHENYL RESIN Phenylessigsure 4-(4-Hydroxy-3-methoxyphenyl)butan-2-on Decan-3-on 6-Gingerol Methoxy
  • (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
  • (S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
  • (S)-8-Oxo-10-(3-methoxy-4-hydroxyphenyl)decane-6-ol
  • 6-Gingerol ,98%
  • 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
  • (5S)-[6]-Gingerol
  • 1-(4'-HYDROXY-3'-METHOXYPHENYL)-5-HYDROXY-3-DECANONE
  • 6-GINGEROL
  • [6]-GINGEROL, ZINGIBER OFFICINALE
  • (5s)-5-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)decan-3-one
  • GINGEROL [6]
  • (S)-5-HYDROXY-1-(4-HYDROXY-3-METHOXY-PHENYL-3-DECANONE
  • 5-HYDROXY-1-(4'-HYDROXY-3'-METHOXYPHENYL)-3-DECANONE
  • (s)-(+)-(6)gingerol
  • (s)-(+)-3-decanon
  • 6-Gingerol, froM Zingiber officinale
  • (s)-(6)-gingerol
  • (s)-3-decanon
  • 6-Gingerol std.
  • 6-GINGEROL, 98% HPLC
  • 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)
  • [6]-Gingerol>
  • [6]-Gingerol Standard
  • (+)-[6]-Gingerol
  • 6-Gingerol USP/EP/BP
  • 3-Decanone,5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-
  • 6-Gingerol, 98%, from Zingiber officinale Rosc.
  • [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem
  • 6-Gingerol 23513-14-6
  • GINGEROL
  • Gingerols
  • rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one
  • Gingerol (6-Gingerol)
  • Pyrroloquinoline Impurity 5
  • 23513-14-6
  • C17H26O4
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Aromatic Phenols
  • Natural Plant Extract
  • The group of Ginerols
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Elisa Kit-plant ELISA Kit
  • 23513-14-6
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