Nisoldipine
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- CAS-Nr.
- 63675-72-9
- Englisch Name:
- Nisoldipine
- Synonyma:
- Sular;NisoL;SYSCOR;Syseor;Nisocor;NORVASC;Nikameal;ZADIPINA;BAYMYCARD;Nisoldipin
- CBNumber:
- CB5147166
- Summenformel:
- C20H24N2O6
- Molgewicht:
- 388.41
- MOL-Datei:
- 63675-72-9.mol
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Nisoldipine Eigenschaften
- Schmelzpunkt:
- 147-148°C
- Siedepunkt:
- 503.3±50.0 °C(Predicted)
- Dichte
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: >10mg/mL
- pka
- 2.67±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow
- Merck
- 14,6565
- InChIKey
- VKQFCGNPDRICFG-UHFFFAOYSA-N
- CAS Datenbank
- 63675-72-9(CAS DataBase Reference)
- NIST chemische Informationen
- Nisoldipine(63675-72-9)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
20/21/22 |
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| S-Sätze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
US7975600 |
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| HS Code |
2933399090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Nisoldipine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
Chemische Eigenschaften
Nisoldipine D4 is Light Tan Crystals
Verwenden
Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate,
calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
Allgemeine Beschreibung
In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
Nisoldipine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nisoldipine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 369)Lieferanten
63675-72-9()Verwandte Suche:
- SYSCOR
- Nisoldipin
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER
- Nisoldipine-d6
- 3-Isobutyl 5-Methyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid-3-methyl 5-(2-methylpropyl) ester
- (±)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate
- 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester
- Nikameal
- Ninobarucin
- Nisomynard
- 3-Methyl 5-(2-Methylpropyl) (4R)-2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Nisoldipine (Sular)
- 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)-, 3-Methyl 5-(2-Methylpropyl)ester
- Nisoldipine-d4
- methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Nisoldipine, >=99%
- 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met
- hyl2-methylpropylester
- BAYMYCARD
- BAY K 5552
- ZADIPINA
- ISOBUTYL METHYL (- 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
- Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI)
- Nisocor
- Sular
- Syseor
- 2，6-Dimethyl-4-(2-nitmphenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-methylpropyl ester
- NORVASC
- NISOLDIPINE
- NISOLIDIPINE
- Nisoldipine>
- Nisoldipine Nisoldipine
- NisoL
- 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Isobutyl Methyl Ester
- Nisoldipine USP/EP/BP
- NisoldipineQ: What is
Nisoldipine Q: What is the CAS Number of
Nisoldipine Q: What is the storage condition of
Nisoldipine Q: What are the applications of
Nisoldipine
- hexakis(dihydrogen phosphate)
- Nisoldipine(BAY-k 5552
- 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-(2-methylpropyl) ester
- 63675-72-9
- C20H18N2O6D6
- C20H24N2O6
- Calcium channel
- Cardiovascular APIs
- Active Pharmaceutical Ingredients
- All Inhibitors
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