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멜라토닌

멜라토닌
멜라토닌 구조식 이미지
카스 번호:
73-31-4
한글명:
멜라토닌
동의어(한글):
멜라토닌
상품명:
Melatonine
동의어(영문):
MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;MELATONIN;melotonin;MELATONINE
CBNumber:
CB5364927
분자식:
C13H16N2O2
포뮬러 무게:
232.28
MOL 파일:
73-31-4.mol

멜라토닌 속성

녹는점
116.5-118 °C (lit.)
끓는 점
374.44°C (rough estimate)
밀도
1.1099 (rough estimate)
굴절률
1.6450 (estimate)
인화점
9℃
저장 조건
-20°C
용해도
Soluble in ethanol to at least 50mg/ml
산도 계수 (pKa)
16.26±0.46(Predicted)
물리적 상태
Powder
색상
white to off-white
Merck
14,5816
BRN
205542
InChIKey
DRLFMBDRBRZALE-UHFFFAOYSA-N
CAS 데이터베이스
73-31-4(CAS DataBase Reference)
NIST
Melatonin(73-31-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,F
위험 카페고리 넘버 60-39/23/24/25-23/24/25-11
안전지침서 24/25-99-53-45-36/37-16-7
유엔번호(UN No.) UN1230 - class 3 - PG 2 - Methanol, solution
WGK 독일 2
RTECS 번호 AC5955000
F 고인화성물질 8-10-23
HS 번호 29379000
유해 물질 데이터 73-31-4(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 3200 mg/kg
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

멜라토닌 MSDS


Melatonine

멜라토닌 C화학적 특성, 용도, 생산

개요

Melatonin, at times referred to as the “hormone of darkness,” normally is secreted during the night. It is synthesized in the pineal gland, and its secretion is controlled by the suprachiasmatic nucleus, following an endogenous circadian rhythm. Studies indicate that melatonin may

화학적 성질

Off-White Powder

출처

Melatonin is a naturally occurring hormone in the body.

용도

Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase

용도

Melatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger

용도

Immunostimulant;Melatonin receptor ligand

용도

Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

정의

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.

World Health Organization (WHO)

Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.

생물학적 활성

Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .

Clinical Use

Melatonin is most effective in young individuals and appears to be less effective in elderly individuals (possibly because of a decreased number of receptors). Melatonin causes a phase shift of approximately 1 hour per day. This means that the use of melatonin in the morning can delay the onset of evening sleepiness, whereas melatonin taken in the evening has been associated with faster onset of sleep and increased total sleep time. Melatonin is sold as a food supplement in the United States, but it has become popular for use as a hypnotic and for alleviating jet lag (a flight across five or more time zones) and helping to resynchronize individuals who have difficulty adapting to night-shift work. have effects on circadian rhythm and sleep processes. The presence of a pharmacologically specific receptor for melatonin in which the molecular structure is known are referred to as MT1, MT2, and MT3 receptors. The MT1 and MT2 receptors are high-affinity G protein coupled receptors, whereas MT3 is a form of quinone reductase. The MT1 receptor appears to be primarily involved in initiating sleep, whereas the MT2 receptor appears to mediate melatonins effect in the eye, circadian rhythm, and vascular effects. The importance of MT3, although widely distributed in different tissues, is currently unknown. The normal physiological concentration of melatonin observed at night is approximately 100 to 200 pg/mL, and oral doses of 0.1 to 0.3 mg of melatonin are adequate to obtain these concentrations even though melatonin frequently is given at doses of 1 to 10 mg to obtain supraphysiological levels. These higher doses may be the reason for some of the side effects not currently associated with the melatonin receptors.

Veterinary Drugs and Treatments

Melatonin may be useful to treat Alopecia-X in Nordic breeds, canine pattern baldness, or canine recurrent flank alopecia in dogs. It has been used anecdotally for the treatment of sleep cycle disorders in cats and geriatric dogs and to treat phobias and separation anxiety in dogs. Melatonin implants are used in the mink and fox pelt industries to promote the development of luxurious hair coats. Implants are also used to improve early breeding and ovulation rates in sheep and goats. Preliminary research is being done for this purpose in horses also.
In pigs, one study (Bubenik, Ayles et al. 1998) demonstrated that 5 mg/kg in feed reduced the incidence of gastric ulcers in young pigs.

멜라토닌 준비 용품 및 원자재

원자재

준비 용품


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