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Melatonine

description Chemical properties Uses Physiological functions Synthesis of Melatonin
Melatonine
Melatonine
CAS No.
73-31-4
Chemical Name:
Melatonine
Synonyms
MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;melotonin;MELATONIN;MELATONINE
CBNumber:
CB5364927
Molecular Formula:
C13H16N2O2
Formula Weight:
232.28
MOL File:
73-31-4.mol

Melatonine Properties

Melting point:
116.5-118 °C(lit.)
Flash point:
9℃
storage temp. 
-15°C
solubility 
Soluble in ethanol to at least 50mg/ml
form 
Powder
color 
white to off-white
Merck 
14,5816
CAS DataBase Reference
73-31-4(CAS DataBase Reference)
NIST Chemistry Reference
Melatonin(73-31-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,F
Risk Statements  60-39/23/24/25-23/24/25-11
Safety Statements  24/25-99-53-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  AC5955000
8-10-23
HS Code  29379000
Hazardous Substances Data 73-31-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Melatonine price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 444300 Melatonin 73-31-4 1gm $71 2017-11-08 Buy
Sigma-Aldrich 1380105 Melatonin United States Pharmacopeia (USP) Reference Standard 73-31-4 150mg $327.1 2017-11-08 Buy
TCI Chemical M1105 Melatonin >98.0%(HPLC)(N) 73-31-4 1g $80 2017-12-01 Buy
TCI Chemical M1105 Melatonin >98.0%(HPLC)(N) 73-31-4 5g $240 2017-12-01 Buy
Alfa Aesar J62452 Melatonin, 99+% 73-31-4 25g $128 2017-11-08 Buy

Melatonine Chemical Properties,Uses,Production

description

Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.

Chemical properties

White or almost white crystalline powder.

Uses

1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
3. Biochemical research.

Physiological functions

1. The effect to brain: the melatonin obtained by brain mainly gathers in midbrain and hypothalamus and it adds the activity of brain pyridoxal kinase, thus promoting glutamic acid decarboxylation to γ-amino butyric acid, 5-hydroxytryptophane decarboxylation to 5-hydroxytryptamine, both of which can inhibit the increase of the neurotransmitter content and have an effect of adjustment and mitigation on central nervous system.
2. The effect to hypothalamus and pituitary: materials like polypeptide produced by pineal body still have thyrotropin-releasing hormone(TRH) and luteinizing hormone releasing hormone(LRH) which are same with what hypothalamus produces except AVT. After injection of melatonin, gonadotropin (GnH)(FSH,LH) and melanocyte stimulating hormone(MSH) are lowered while growth hormone increases. Cutting pineal gland will cause pituitary hypertrophy, increase pituitary secretion and lower prolactin(PRL) and antidiuretic hormone (ADH).
3. The relation to gonad: melatonin has an inhibitory effect on the reproductive system. Clinically, main cytoma of pineal body can lead to pubertal delay and when teratoma appears in pineal body, it may result in sexual precocity because main cells are excluded. Ambient light and sympathetic nerve can affect the function of the reproductive system by inhibiting the synthesis and release of melatonin in pineal gland.
4. The relation to thyroid: by injecting melatonin, thyroid secretion will decrease. This may be caused through the inhibition of the hypothalamus release and Thyroid Stimulating Hormone (TSH) secretion of pituitary, hence holding back the function of thyroid.
5. The relation to adrenal cortex: melatonin has a strong inhibitory effect on adrenal cortex. If we inject pineal body extracts to healthy people, we will find that their aldosterone secretion and 17-ketosteroid output will decrease.
6. The relation to pancreatic island: melatonin can lower blood glucose and increase sugar tolerance. In conclusion, pineal gland can assist pituitary to jointly adjust endocrine function and play an vital role in keeping relatively constant in body environment and controlling some endocrine function, especially for gonad.

Synthesis of Melatonin

Pineal cells obtain tryptophan from blood circulation and become 5-hydroxytryptophane catalyzed by hydroxylase and 5-hydroxytryptophane turns into 5-hydroxytryptamine after decarboxylated by decarboxylase. There are three possible changes for 5-hydroxytryptamine: for the first part it may turn into 5-hydroxyl-benzpyrole acetic acid when deaminated by monoamine oxidase; for another part, some 5-hydroxytryptamine will leave the pineal cell and be taken in by sympathetic nerve ending and stored with neurotransmitter and noradrenalin; for the remaining part, the 5-hydroxytryptamine will be acetylated by N-acetyl-5-hydroxy tryptamine transferase and then be o-methoxy by hydroxylation indole-o-methyl converzyme, finally forming melatonin. After being synthesized, melatonin will be released by cells and enter into blood circulation through cerebrospinal fluid or directly, where noradrenalin may strengthen the synthesis, the speed of which depends on activity of hydroxylase in liver microsomes. Catalyzed by the hydroxylase, 6-hydroxylmelatonin is formed, soon afterwards it combines with glucuronic acid and sulfate, excreting through urine.

Chemical Properties

Off-White Powder

Uses

sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger

Uses

Immunostimulant;Melatonin receptor ligand

Uses

Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

Uses

Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase

Definition

ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.

Biological Activity

Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .

Melatonine Preparation Products And Raw materials

Raw materials

Preparation Products


Melatonine Suppliers

Global( 337)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
0592-6210733
0592-6210733 sales@mainchem.com CHINA 1948 55
Sichuan Tuskwei Import and Export Trade Co., Ltd.
86-311-83306736
86-311-83306736 sales@tuskwei.com CHINA 171 58
Shanghai ChengShao Biological Technology Co., Ltd. 021-61847300 13341622919
021-61847300 shcss01@163.com China 4815 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 info@efebio.com China 1998 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 info@tnjchem.com China 1944 62
Wuhan HengWo Technology Co., Ltd. 0571-87963082 18062502932
0571-87963082 chemicala@163.com China 5140 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
Nanjing Elegant Nutraceuticals Co., Ltd 0086-25-83241153, 83241163
0086-25-83241173 sales@elegantnutri.com China 51 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3588 66

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