Tipifarnib
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- CAS-Nr.
- 192185-72-1
- Englisch Name:
- Tipifarnib
- Synonyma:
- R115777;CS-2330;IND 58359;Zarnestra;ipifarnib;TIPIFARNIB;(R)-(+)-R 115777;Tipifarnib(R115777);TIPIFARNIB ZARNESTRA;Tipifarnib USP/EP/BP
- CBNumber:
- CB61011759
- Summenformel:
- C27H22Cl2N4O
- Molgewicht:
- 489.4
- MOL-Datei:
- 192185-72-1.mol
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Tipifarnib Eigenschaften
- Schmelzpunkt:
- 211-213°C (dec.)
- Siedepunkt:
- 681.7±55.0 °C(Predicted)
- Dichte
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 7.20±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D 17 to 24°, c = 1 in methanol
Tipifarnib Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White to Pale Beige Solid
Verwenden
A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of
myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).
Allgemeine Beschreibung
Pre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500?nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.
Tipifarnib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tipifarnib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 152)Lieferanten
192185-72-1()Verwandte Suche:
- TIPIFARNIB
- TIPIFARNIB ZARNESTRA
- (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone
- Zarnestra
- (R)-(+)-R 115777
- 6-[(R)-AMino(4-chlorophenyl)(1-Methyl-1H-iMidazol-5-yl)Methyl]-4-(3-chlorophenyl)-1-Methyl-2(1H)-quinolinone
- Tipifarnib(Zarnestra,NSC-702818, R-115777)
- IND 58359
- R115777
- Tipifarnib(R115777)
- (R)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
- Tipifarnib (IND 58359
- ipifarnib
- CS-2330
- ZARNESTRA; IND 58359; R115777; IND-58359; IND58359; R-115777; R 115777
- Tipifarnib (Zarnestra) IND 58359, R115777
- 2(1H)-Quinolinone, 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
- Tipifarnib USP/EP/BP
- 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
- 192185-72-1
- 192185-71-4
- Inhibitors
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Tyrosine Kinase Inhibitors
- Inhibitor
- Antineoplastic
