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Sarpogrelate hydrochloride

Sarpogrelate hydrochloride Struktur
135159-51-2
CAS-Nr.
135159-51-2
Englisch Name:
Sarpogrelate hydrochloride
Synonyma:
SARPOGRELATE HCL;Anplag;MCI 9042;LS187,118;LS 187,118;LS-187,118;Sarpogrelate-D3 HCl;Sarpogrelate hydroch;SARPOGRELATE HYDROCHLORIDE;Sarpogrelate Hydrochloride RS
CBNumber:
CB6511456
Summenformel:
C24H32ClNO6
Molgewicht:
465.96698
MOL-Datei:
135159-51-2.mol
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Sarpogrelate hydrochloride Eigenschaften

Schmelzpunkt:
145-148°C
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
deionized water: ≥5mg/mL
Aggregatzustand
solid
InChIKey
POQBIDFFYCYHOB-UHFFFAOYSA-N
CAS Datenbank
135159-51-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 22-50/53
S-Sätze: 60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Sarpogrelate hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT2 receptor antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo platelet aggregation stimulated by serotonin in combination with collagen and suppression of blood vessel constriction mediated by 5-HT2 in vitro. Its antithrombotic effects have been demonstrated in several in vivo experimental models including reduction of the mortality rate in acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for patients with Type 2 diabetes mellitus, in whom 5-HT2mediated amplification of collageninduced platelet aggregation is significantly increased.

Chemische Eigenschaften

White Solid

Verwenden

Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist ress-induced hemolysis.

Biologische Aktivität

Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .

Sarpogrelate hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1-(Dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-ol 1-(Dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]-2-propanol hydrochloride Bernsteinsureanhydrid

Downstream Produkte

Sarpogrelate hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 260)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Career Henan Chemica Co
+86-0371-86658258 15093356674;
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Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Standardpharm Co. Ltd. 		86-714-3992388
overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226
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Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
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CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 47465 58

135159-51-2()Verwandte Suche:

4-Methoxybenzylalkohol 4-Methoxyphenylacetonitril Meclofenoxathydrochlorid 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (Trifluormethoxy)benzol p-Anissure Ethyl(methyl)amin Topotecan hydrochloride Methylsalicylat Anisaldehyd 4-Methoxyphenol Tribenuron methyl 4-Methoxy-anilin Thiophanat-methyl Cefetamet pivoxil hydrochloride Phenoxybenzamin Sarpogrelate Methyl
  • Sarpogrelate-D3 HCl
  • Anplag
  • Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (9CI)
  • Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride, (+-)-
  • MCI 9042
  • 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid hydrochloride
  • 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxo-butanoic acid hydrochloride
  • 4-[1-(dimethylaminomethyl)-2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethoxy]-4-keto-butyric acid hydrochloride
  • Succinicacidmono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl)esterhydrochloride
  • Butanedioic acid 1-[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester hydrochloride
  • Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)et hyl]phenoxy)ethyl) ester hydro
  • SARPOGRELATE HYDROCHLORIDE
  • (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
  • 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}pr
  • Sarpogrelate Hydrochloride intermediate
  • 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride (1:1)
  • Sarpogrelate hydrochloride, >=99%
  • 4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride
  • Butanedioic acid, mono[2-(dimethylamino)-1-[[
  • ANPLAG;MCI 9042;MCI9042;MCI-9042
  • Sarpogrelate Hydrochloride （mixture of isomers）
  • Sarpogrelate Hydrochloride RS
  • Sarpogrelate hydrochloride USP/EP/BP
  • Sarpogrelate hydroch
  • (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
  • Sarpogrelate HydrochlorideQ: What is Sarpogrelate Hydrochloride Q: What is the CAS Number of Sarpogrelate Hydrochloride Q: What is the storage condition of Sarpogrelate Hydrochloride
  • SARPOGRELATE HCL
  • LS 187,118
  • LS187,118
  • LS-187,118
  • 135159-51-2
  • C24H31NO6HCl
  • C24H32ClNO6
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