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4,4'-Diamino-diphenyl-methan Produkt Beschreibung

4,4'-Methylenedianiline Struktur
101-77-9
CAS-Nr.
101-77-9
Bezeichnung:
4,4'-Diamino-diphenyl-methan
Englisch Name:
4,4'-Methylenedianiline
Synonyma:
MDA;DADPM;ht972;Tonox;HT 972;Tonox R;MDA-100;Tonox 22;Curithane;sumicurem
CBNumber:
CB7718182
Summenformel:
C13H14N2
Molgewicht:
198.26
MOL-Datei:
101-77-9.mol

4,4'-Diamino-diphenyl-methan Eigenschaften

Schmelzpunkt:
89-91 °C(lit.)
Siedepunkt:
242 °C2 mm Hg(lit.)
Dichte
1.15
Brechungsindex
1.5014 (estimate)
Flammpunkt:
430 °F
Löslichkeit
water: soluble
Aggregatzustand
neat
pka
5.32±0.25(Predicted)
Wasserlöslichkeit
Slightly soluble. <0.1 g/100 mL at 19 ºC
Merck 
14,2980
BRN 
474706
CAS Datenbank
101-77-9(CAS DataBase Reference)
NIST chemische Informationen
Benzenamine, 4,4'-methylenebis-(101-77-9)
IARC
2B (Vol. 39, Sup 7) 1987
EPA chemische Informationen
4,4'-Methylenedianiline (101-77-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,N
R-Sätze: 45-39/23/24/25-43-48/20/21/22-51/53-68
S-Sätze: 53-45-61
RIDADR  UN 2651 6.1/PG 3
WGK Germany  3
RTECS-Nr. BY5425000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29215900
Giftige Stoffe Daten 101-77-9(Hazardous Substances Data)
Toxizität LD50 oral in rabbit: 620mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenität Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

4,4'-Diamino-diphenyl-methan Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE BIS BLASSGELBE FLOCKEN MIT CHARAKTERISTISCHEM GERUCH. VERFäRBEN SICH DUNKEL BEI KONTAKT MIT LUFT.

CHEMISCHE GEFAHREN

Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Anilin und Stickstoffoxiden. Schwache Base. Reagiert sehr heftig mit starken Oxidationsmitteln.

ARBEITSPLATZGRENZWERTE

TLV: 0.1 ppm (als TWA); Hautresorption; Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: Hautresorption; Sensibilisierung der Haut; Krebserzeugend Kategorie 2 (DFG 2008).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

INHALATIONSGEFAHREN

Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Möglich sind Auswirkungen auf die Leber mit nachfolgenden Leberschäden.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Möglicherweise krebserzeugend für den Menschen.

LECKAGE

Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät. NICHT in die Umwelt gelangen lassen.

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
R48/20/21/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R68:Irreversibler Schaden möglich.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Beschreibung

Diaminodiphenylmethane is an aromatic diamine used as a curing agent in epoxy res ins of t11e bisphenol A type, as in the production of plastics, isocyanates, adhesives, elastomers, polyuret11ane (elastic and rigid foams, paints, lacquers, adhesives, binding agents, synt11etics rubbers, and elastomeric fibers) and butyl rubber. Diaminodiphenylmet11ane is also a by-product of azo dyes. It is also possibly formed by hydrolysis of diphenylmethane-4A'-diisocyanate.

Chemische Eigenschaften

white to yellow or beige flakes or crystals

Chemische Eigenschaften

4,4’-Diaminodiphenylmethane is a pale yellow crystalline solid (turns light brown on contact with air) with a faint amine-like odor.

Verwenden

4,4'-methylenedianiline be used as organic intermediates. Mainly used for the synthesis of polyimide and as curing agent of epoxy resin.

Verwenden

As chemical intermediate in production of isocyanates and polyisocyantes for preparation of polyurethane foams, Spandex fibers; as curing agent for epoxy resins and urethane elastomers; in production of polyamides; in the determination of tungsten and sulfates; in preparation of azo dyes; as corrosion inhibitor.

Verwenden

4,4'-Diaminodiphenyl-methane is used in the determination of tungsten and sulfates; in the preparation of azo dyes; cross-linking agent for epoxy resins; in the preparation of isocyanates and polyisocyanates; in the rubber industry as a curative for neoprene, as an anti-frosting agent (antioxidant) in footwear; raw material in preparation of poly(amide-imide) resins (used in magnet-wire enamels); curing agent for epoxy res ins and urethane elastomers; corrosion inhibitor; rubber additive (accelerator, antidegradant, retarder) in tires and heavy rubber products; in adhesives and glues, laminates, paints and inks, PVC products, handbags, eyeglass frames, plastic jewelry, electric encapsulators, surface coatings, spandex clothing, hairnets, eyelash curlers, earphones, balls, shoe soles, face masks.

Definition

ChEBI: An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.

Allgemeine Beschreibung

A tan flake or lump solid with a faint fishlike odor. May be toxic by inhalation or ingestion, and may be irritating to skin. Insoluble in water.

Air & Water Reaktionen

Oxidizes slowly in air in a reaction catalyzed by light. Somewhat hygroscopic. Insoluble in water.

Reaktivität anzeigen

4,4'-Methylenedianiline polymerizes if heated above 257° F. Incompatible with strong oxidizing agents. 4,4'-Methylenedianiline is also incompatible with acids. Catalyzes isocyanate-alcohol and epoxide reactions. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Brandgefahr

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Sicherheitsprofil

Confirmed carcinogen with experimental tumorigenic data. Human poison by ingestion. Poison by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: rigidity, jaundice, other liver changes. An eye irritant. Mutation data reported. It is not rapidly absorbed through the skin. Combustible when exposed to heat or flame. When heated to decomposition it emits highly toxic fumes of aniline and NOx.

mögliche Exposition

Used as an intermediate and as a curing agent. Approximately 99% of the DDM produced is con- sumed in its crude form (occasionally containing not more than 50% DDM and ply-DDM) at its production site by reac- tion with phosgene in the preparation of isocyanates and poly- isocyanates. These isocyanates and polyisocyanates are employed in the manufacture of rigid polyurethane foams which find application as thermal insulation. Polyisocyanates are also used in the preparation of the semiflexible polyure- thane foams used for automotive safety cushioning. DDM is also used as: an epoxy hardening agent; a raw material in the production of polyurethane elastomers; in the rubber industry as a curative for Neoprene and as an antifrosting agent (anti- oxidant) in footwear; a raw material in the production of Quana nylon; and a raw material in the preparation of poly (amide-imide) resins (used in magnet wire enamels).

Carcinogenicity

4,4′-Methylenedianiline and its dihydrochloride salt are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

MDA is a pale brown crystalline powder with a faint aminelike odor. Exposure to air and light results in polymerization and oxidation of MDA. When heated, MDA produces toxic fumes of aniline and nitrogen oxides.
Most MDA enters the environment when it is produced or used to make other compounds. Forty-five percent of the produced compound is released to deep soil, 52.6% to the air, and 2.4% to land and water. Once in the environment, it will be mainly present as tiny particles in the air and it is removed from the atmosphere by dry deposition, rain, and snow scavenging. A small amount is transformed by reaction with hydroxyl radicals. In water, most of MDA will attach to particles and sediments, and will eventually settle to the bottom.
The estimated half-life of biodegradation in surface water, groundwater, and soil is 1–7 days, 2–14 days, and 1–7 days, respectively. With respect to aquatic ecosystems, bioconcentration factor values of 3.0–14 suggest that bioconcentration is low, in addition this compound does not tend to build up in the food chain. When released to soil, it is expected to have slight to no mobility. Similarly, volatilization from both moist and dry soil surfaces is not expected to be important.

Versand/Shipping

UN2651 4,40 -Diaminodiphenyl methane, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

läuterung methode

Crystallise the amine from water, 95% EtOH or *benzene. [Beilstein 13 IV 390.]

Toxicity evaluation

Currently, the mechanism of action is not completely understood and has been mostly assessed from information on structurally similar compounds. Many of the toxic properties of MDA have been attributed to metabolic intermediates, as these compounds are metabolically activated by N-oxidation to metabolites, such as N-hydroxymethylenedianiline, that react with DNA, RNA, and proteins.
Different studies suggest that both liver and thyroid are targets for MDA toxicity in humans and animals. Liver toxicity has been linked to impair mitochondrial function and structure, apoptosis, and increased oxidative stress. It may be caused by a reactive electrophile formed during metabolism since liver has the enzymatic routes necessary for such activation. Experimental studies indicate that biliary epithelial cells are damaged earlier than parenchymal cells and bile is a major route of exposure to MDA. The mechanism of thyroid toxicity has not yet been resolved. It has been observed that MDA exposure can induce a slight decrease in thyroid hormones in rats, thus triggering secretion of thyroid-stimulating hormone (TSH), which induced thyroid hyperplasia. Some of the induced adverse effects observed after MDA exposure (e.g., reduced food consumption, lower body weight gain, and effects on red cells, lymphocytes, and clotting parameters) could be explained as secondary responses.
MDA is carcinogenic to animals. The mechanism of liver or thyroid tumor development remains unclear. Even if cell injury may give indications of a nongenotoxic mechanism, it remains still unproved, and there are also positive genotoxic data in vitro and in vivo which indicate that a genotoxic mechanism may be related to the formation of a reactive metabolic intermediate cannot be excluded. Regarding thyroid cancer, hypersecretion of TSH may have a contribution to tumor formation.

Inkompatibilitäten

Dust forms and explosive mixture with air. May polymerize in temperatures .125℃ . A weak base. Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids. Flammable gas- eous hydrogen may be generated in combination with strong reducing agents, such as hydrides .

Waste disposal

Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices).

4,4'-Diamino-diphenyl-methan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4,4'-Diamino-diphenyl-methan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 324)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Chengdu Yuanda Chemical Co., Ltd
86-28-85356300 / 18980937689
86-28-85356300 sales@ydachem.com CHINA 94 58
Shanghai Daeyeon Chemicals Co., Ltd
+8615900664856 +86-021-6447-8606
daeyeon001@vip.163.com China 2026 58
Dayang Chem (Hangzhou) Co.,Ltd.
17705817739 +86-571-88938639
+86-571-88938652,+86-571- 88492614 info@dycnchem.com CHINA 52932 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.
0431-80514535 13634302652
0431-88607838 Extension@chemextension.com CHINA 967 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5882 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

101-77-9(4,4'-Diamino-diphenyl-methan)Verwandte Suche:


  • Bis-(4-aMino
  • methylenebis(aniline)
  • MDA
  • DIANILINOMETHANE
  • Di-(4-aminophenyl)methane
  • DADPM
  • bis(p-aminophenyl)methane
  • BIS-(4-AMINOPHENYL)METHANE
  • ZERENEX ZX004995
  • P,P'-METHYLENEDIANILINE
  • P,P'-DIAMINODIPHENYLMETHANE
  • 4,4-Diaminodiphenylmethane~MDA
  • 4,4′-Metylene dianiline
  • 4,4'-METHYLENEDIANILINE
  • 4,4-METHYLENEDIANILINE
  • 4,4'-Methylenebisbenzeneamine
  • 4,4'-Diphenylmethanediamine
  • 4,4'-DIAMINODIPHENYLMETHANE
  • 4-(4-AMINOBENZYL)ANILINE
  • Bis-(4-aminophenyl)methane Solution, 100ppm
  • Vulkanox MB2/MG
  • ,4’-methylenedianiline
  • ,4'-Methylenebisaniline
  • 4-(4-Aminobenzyl)phenylamine
  • 4,4’-diaminodiphenylmethan
  • 4,4’-diaminoditan
  • 4,4’-methylenebisaniline
  • 4,4’-methylenebis-benzenamin
  • 4,4’-methylenebisbenzenamine
  • 4,4’-methylenebis-Benzenamine
  • 4,4’-methylenedianilin
  • 4,4’-methylenedi-anilin
  • 4,4'-Diaminodiphenylmethan
  • 4,4'-Methylenebis[aniline]
  • 4,4'-Methylenedibenzenamine
  • Ancamine tl
  • ancaminetl
  • Aniline, 4,4'-methylenedi-
  • aniline,4,4’-methylenedi-
  • Araldite hardener 972
  • aralditehardener972
  • avalditeht972
  • benzenamine,,4’-methylenebis-
  • benzenamine,4,4’-methylenebis-
  • Bis(aminophenyl)methane
  • Bis-p-aminofenylmethan
  • bis-p-aminofenylmethan(czech)
  • Curithane
  • Diaminodiphenylmethane
  • Dianiline, 4,4'-methylene-
  • Dianilinemethane
  • Epicure DDM
  • epicureddm
  • Epikure DDM
  • epikureddm
  • HT 972
  • ht972
  • Jeffamine AP-20
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