O-Desmethylvenlafaxine
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- CAS-Nr.
- 93413-62-8
- Englisch Name:
- O-Desmethylvenlafaxine
- Synonyma:
- DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36;Venlafaxine O-Desmethyl
- CBNumber:
- CB8496834
- Summenformel:
- C16H25NO2
- Molgewicht:
- 263.38
- MOL-Datei:
- 93413-62-8.mol
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O-Desmethylvenlafaxine Eigenschaften
- Schmelzpunkt:
- 208-213°C
- Siedepunkt:
- 403.8±25.0 °C(Predicted)
- Dichte
- 1.115±0.06 g/cm3(Predicted)
- Flammpunkt:
- 9℃
- storage temp.
- 2-8°C
- Löslichkeit
- insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
- pka
- 10.04±0.26(Predicted)
- InChIKey
- KYYIDSXMWOZKMP-UHFFFAOYSA-N
- LogP
- 0.33 at 25℃ and pH6
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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O-Desmethylvenlafaxine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Desvenlafaxine is a new member of the SNRI class of antidepressants.
It is marketed as an extended release tablet for once-daily oral treatment
of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is
the major active metabolite of the previously marketed antidepressant
venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more
potent inhibitor of serotonin and norepinephrine reuptake (IC
50＝47 and
531 nM, respectively) than that of dopamine (62% inhibition at 100 mM)
in in vitro studies. It does not have significant in vitro affinity for other
neurotransmitter reporters such as a1-adrenergic, H1-histaminergic,
or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a
racemic mixture. Specific pharmacological properties of the enantiomers
of desvenlafaxine have not been reported.
Chemische Eigenschaften
White Solid
Verwenden
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Definition
ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
Allgemeine Beschreibung
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq
? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor
? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
O-Desmethylvenlafaxine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
O-Desmethylvenlafaxine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 238)Lieferanten
93413-62-8()Verwandte Suche:
- O-DESMETHYL VENLAFAXINE-D10
- DL-O-Desmethylvenlafaxin
- 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
- O-Desmethylvenlafaxine
- Desvenlafaxine(O-Desnethylvenfaxine)
- 1-[1-(4-Hydroxyphenyl)-2-dimethylaminoethyl]cyclohexanol
- 4-[1-(1-Hydroxycyclohexyl)-2-(dimethylamino)ethyl]phenol
- Desmethylvenlafaxine
- Wy-45233
- O-desMethylvenlafaxin
- DVS 233
- desvenlafaxine
- O-DesMethyl Venlafaxine Hydrochloride
- Venlafaxine O-DesMethyl IMpurity
- Desvenlafaxine (O-DesMethyl venlafaxine)
- Phenol,4-[2-(diMethylaMino)-1-(1-hydroxycyclohexyl)ethyl]-
- Desvenlafaxine Base
- O-Desmethylvenlafaxine solution
- O-Desmethylvenlafaxine(DL)
- Desvenlafaxine impurity C
- Venlafaxine-d10 HCl
O-Desmethyl Venlafaxine-d10
- O-Desmethylvenlafaxine, 98%, a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor
- D,L-O-Desmethyl Venlafaxine (100 μg/mL in Methanol)
- O-Desmethylvenlafaxine USP/EP/BP
- Desvenlafaxine (WY 45233
- Venlafaxine Impurity 36
- DesvenlafaxineQ: What is
Desvenlafaxine Q: What is the CAS Number of
Desvenlafaxine Q: What is the storage condition of
Desvenlafaxine Q: What are the applications of
Desvenlafaxine
- 93413-62-8 O-Desmethylvenlafaxine
- Venlafxine-O-Desmethyl
- Venlafaxine O-Desmethyl
- O-Desmethyl Venlafaxine (Free base)
- 93413-62-8
- 96413-62-8
- PRISTIQ
- Metabolite & impurity
- Metabolites
- Intermediates & Fine Chemica
- Pfizer Compounds
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
