Elacridar
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- CAS-Nr.
- 143664-11-3
- Englisch Name:
- Elacridar
- Synonyma:
- GG 918;GW-918;GW 0918;CS-1717;GW120918;elacridar;GF 120918;EOS-62436;Elacridar, >=98%;Ecrita impurity 1
- CBNumber:
- CB9855393
- Summenformel:
- C34H33N3O5
- Molgewicht:
- 563.64
- MOL-Datei:
- 143664-11-3.mol
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Elacridar Eigenschaften
- Schmelzpunkt:
- 216-218°C
- Siedepunkt:
- 701.6±60.0 °C(Predicted)
- Dichte
- 1.264±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble2mg/mL (clear solution, warmed)
- Aggregatzustand
- powder
- pka
- 12.58±0.70(Predicted)
- Farbe
- white to beige
- CAS Datenbank
- 143664-11-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AR7621300 |
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| HS Code |
29334900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Elacridar Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Yellow Solid
Verwenden
Elacridar has been used:
- as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinib
- as an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicity
- to treat rhodamine 123 (Rh123) labeled cells to set sorting gates in fluorescence-activated cell sorting (FACS)
Biochem/physiol Actions
GF120918 (Elacridar) is a very potent inhibitor of the ABC transporters MDR-1 (P-gp) and BCRP. GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to increased levels of anti-HIV drugs in the brain and CNS.
Elacridar Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Elacridar Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 215)Lieferanten
143664-11-3()Verwandte Suche:
- elacridar
- n-[4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10h-acridine-4-carboxamide
- GF 120918
- GG 918
- GW 0918
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide
- 1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid
- GW 0918
N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide
- Elacridar (GF120918)
- GW120918
- Elacridar, >=98%
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-phenyl)-5-methoxy-9-oxo-9,10-dih
- GF 120918;GF120918;GF-120918
- GW-918
- CS-1717
- EOS-62436
- Elacridar (GW0918)
- Elacridar Elacridar
- 4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-
- Elacridar USP/EP/BP
- Ecrita impurity 1
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carb
- 143664-11-3
- C34H33N3O5
- Miscellaneous
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
