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Colchicin

Colchicin Structure
Colchicin structure
CAS No.
64-86-8
Chemical Name:
Colchicin
Synonyms
Colchlcine;(S)-colchicine;(S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE;nsc757;COLCIN;NSC 757;Condylon;Colchicin;Colsaloid;COLCHISOL
CBNumber:
CB00129729
Molecular Formula:
C22H25NO6
Molecular Weight:
399.44
MDL Number:
MFCD00078484
MOL File:
64-86-8.mol
MSDS File:
SDS
Last updated:2024-04-26 14:09:12
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Colchicin Properties

Melting point 150-160 °C (dec.)(lit.)
alpha -250 º (c=1, alcohol)
Boiling point 522.37°C (rough estimate)
Density 1.2770 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. 2-8°C
solubility H2O: 10 mg/mL
pka 12.36(at 20℃)
form powder
color white to yellow with a green cast
Water Solubility 45 g/L (20 ºC)
Sensitive Light Sensitive
Merck 14,2471
BRN 2228813
BCS Class 3
Stability Stable. Light sensitive. Incompatible with strong oxidizing agents.
InChIKey IAKHMKGGTNLKSZ-INIZCTEOSA-N
LogP 1.300
CAS DataBase Reference 64-86-8(CAS DataBase Reference)
EWG's Food Scores 4-7
NCI Dictionary of Cancer Terms colchicine
FDA UNII SML2Y3J35T
NCI Drug Dictionary colchicine
ATC code M04AC01
Proposition 65 List Colchicine
NIST Chemistry Reference Colchicine(64-86-8)
EPA Substance Registry System Colchicine (64-86-8)

Pharmacokinetic data

Protein binding 30-50%
Excreted unchanged in urine 5-20%
Volume of distribution 1-2(L/kg)
Biological half-life 4.4 / 18.8

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H340
Precautionary statements  P202-P264-P270-P280-P301+P310-P405
Hazard Codes  T+,T,Xi
Risk Statements  26/28-41-46
Safety Statements  13-45-36/37/39-28-26-53
RIDADR  UN 1544 6.1/PG 1
WGK Germany  3
RTECS  GH0700000
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29399990
Toxicity LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)
NFPA 704
1
3 0

Colchicin price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001958 Colchicine for system suitability A European Pharmacopoeia (EP) Reference Standard 64-86-8 Y0001958 $163 2024-03-01 Buy
Sigma-Aldrich PHL89610 Colchicine phyproof? Reference Substance 64-86-8 25mg $344 2024-03-01 Buy
Sigma-Aldrich BP1150 Colchicine British Pharmacopoeia (BP) Reference Standard 64-86-8 100MG $257 2024-03-01 Buy
Sigma-Aldrich 234115 Colchicine,Colchicumautumnale-CAS64-86-8-Calbiochem Colchicine,Colchicumautumnale,CAS64-86-8,isaninhibitorofmitosisthatdi 64-86-8 1g $107 2024-03-01 Buy
Sigma-Aldrich 234115 Colchicine,Colchicumautumnale-CAS64-86-8-Calbiochem Colchicine,Colchicumautumnale,CAS64-86-8,isaninhibitorofmitosisthatdi 64-86-8 5G $549 2024-03-01 Buy
Product number Packaging Price Buy
Y0001958 Y0001958 $163 Buy
PHL89610 25mg $344 Buy
BP1150 100MG $257 Buy
234115 1g $107 Buy
234115 5G $549 Buy

Colchicin Chemical Properties,Uses,Production

Description

Colchicin is a kind of alkaloid extracted from the crom or seed of the lily family plants, Colchicum autumnale, and is naturally presented in the Liliaceae Garland and Iphigenia with the contents being 0.11% and 0.1%. It is pale yellow needle crystals. It has slight odor and bitter taste with the melting point being 157℃. It is soluble in cold water, alcohol, chloroform and formaldehyde with poor solubility in hot water and is not easily soluble in benzene and ether.

Physical properties

Colchicin appears as odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light.

Uses

Colchicin is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus."Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events.

Biological Functions

Colchicin interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicin may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis.

Hazard

Colchicin poisoning has a certain incubation period with symptoms often happening at 3d~6d after oral administration or injection. Symptoms include throat burning, nausea, vomiting, abdominal pain, diarrhea, watery stools, hematuria, urine retention, numbness, aching limbs, muscle cramps, hair loss, dilated pupils, and convulsion, paralysis of the central nervous system, and respiratory depression and death. In addition, it can also produce local reactions such as when the drug liquid is leaked out from the blood vessel upon injection, local tissue necrosis can occur. Poisoning is usually caused by ingestion or drug overdose.

Health Hazard

Main risks and target organs: Colchicin exerts a multiorgan toxicity. The main toxic effects are related to the effects of colchicine on cellular division and account for diarrhea, bone marrow depression, alopecia. Other acute effects are hypovolemia, shock, and coagulation disturbances, which may lead to death.

Physiological effects

Colchicin ameliorates the symptoms of gout and Familial Mediterranean fever. It possesses anti-inflammatory, anti-fibrotic, and cardiovascular protective effects. Colchicin was shown to exhibit anticancer properties, such as the inhibition of cancer cell migration and angiogenesis.

Metabolism

Colchicin undergoes some hepatic metabolism. Colchicin is partially deacetylated in the liver. Large amounts of colchicin and of its metabolites undergo enterohepatic circulation. This may explain the occurrence of a second plasma peak concentration observed 5 to 6 hours after ingestion.

Toxicity

The human lethal dose of colchicine is 6mg~7mg. Mouse oral-LD was 66.6mg/kg; LD50-intraperitoneal injection of mice is 3.5mg/kg. LD50-subcutaneous injection of rat is 4mg/kg.

Colchicin Preparation Products And Raw materials

Raw materials

weak

Preparation Products

Acetamide, N,N'-[(7S,7bR,8aS,8bS,9aR,10S,16cS,16dR,16eR,16fS)-5,6,7,7b,8,8a,8b,9,9a,10,11,12,16c,16d,16e,16f-hexadecahydro-1,2,3,8a,8b,14,15,16-octamethoxy-8,9-dioxobisbenzo[3',4']cyclohepta[1',2':3,4]cyclobuta[1,2-c:1',2'-c']cyclobuta[1,2-a:4,3-a']dicyclopentene-7,10-diyl]bis- GAMMA-LUMICOLCHICINE thiocolchicine

Colchicin Suppliers

Global( 701)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12470 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 6011 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 		+8617702722807 admin@hbouhuang.com China 3001 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9341 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Shanxi Naipu Import and Export Co.,Ltd 		+86-13734021967 +8613734021967 kaia@neputrading.com China 1011 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2931 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Anhui Ruihan Technology Co., Ltd 		58
Ouhuang Engineering Materials (Hubei) Co., Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Shanxi Naipu Import and Export Co.,Ltd 		58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		58
Chengdu Biopurify Phytochemicals Ltd. 		58

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View Lastest Price from Colchicin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium tetraborate pentahydrate pictures 2023-08-21 Sodium tetraborate pentahydrate
12179-04-3
 1kg 99% 100tons Anhui Ruihan Technology Co., Ltd

Colchicine Spectrum

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N-((S)-1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL)-ACETAMIDE n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide len-7-yl)- N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-acetamid n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-acetamid N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-Acetamide n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamid N-Acetyl trimethylcolchicinic acid methylether n-acetyltrimethylcolchicinicacidmethylether NSC 757 Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10- tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)- COLCHICINE extrapure Colchicine99% (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[alpha]heptalen-7-yl)acetamide (-)-N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide Colchicine, 95% (dry wt.), may cont. up to 2% water and 8% ethyl acetate Colchicine,97% (S)-Colchicine >95% COLCHICINE CRYST. RESEARCH GRADE Colchicine (350 mg) Colchicine, 97% 500MG Colchicine (dry wt.), may cont. up to 2% water and 8% ethyl acetate 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5h)-one ACETAMIDE, N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL-, (S) Colchicine USP COLCHICINE CRYSTALLINE COLCHICINE-PLANT CELL CULTURE TESTED COLCHICINE, >97.0% (HPLC) COLCHICINE 98+% BY HPLC COLCHICINE: ACETAMIDE,N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)-,(S)-, Colchicine,96% Colchicine >95% N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide Acetamide, N-(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoaheptalen-7-yl- COLCHICINE(RG) 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-benzo(a)heptalen-9(5h)-on 7-alpha-h-colchicine 7alpha-h-colchicine 7alphaH-Colchicine Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)heptalen-7-yl)- acetamide,n-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(alpha)hepta benzo(a)heptalen-9(5h)-one Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy- Colchicin Colchicina Colchicine bp Colchineos Colsaloid component of ColBenemid Condylon nsc757 COLCHISOL COLCIN COLCHICEINE METHYL ETHER COLCHICINE COLCHICINE, COLCHICUM AUTUMNALE