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Alpha-D-Lactose monohydrate

Alpha-D-Lactose monohydrate structure

CAS No.: 5989-81-1

Chemical Name:: Alpha-D-Lactose monohydrate

Synonyms: LACTOSE MONOHYDRATE;α-Lactose;α-Lactose monohydrate;ALPHA-LACTOSE MONOHYDRATE;α-D-Lactose monohydrate;MILK SUGAR;ALPHA-D-LACTOSE;Pharmatose 150M;LACTOSE MONOHYDRATE (ALPHA-FORM);A-LACTOSE

CBNumber:: CB0177832

Molecular Formula:: C12H24O12

Molecular Weight:: 360.31

MDL Number:: MFCD00150747

MOL File:: 5989-81-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 16:06:25

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Alpha-D-Lactose monohydrate Properties

Melting point	219 °C
Boiling point	412.35°C (rough estimate)
alpha	[α]D20+52.2～+52.8°
Density	1,53 g/cm³
RTECS	OD9625000
refractive index	1.6480 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: soluble1M, clear, colorless
form	Solid
color	White to Off-White
PH	pH (50g/l, 25℃) : 4.0～6.0
biological source	bovine milk
Water Solubility	Soluble in water.
Stability	Hygroscopic
InChI	1S/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17;/h3-20H,1-2H2;1H2/t3-,4-,5+,6+,7-,8-,9-,10-,11+,12+;/m1./s1
InChIKey	WSVLPVUVIUVCRA-KPKNDVKVSA-N
SMILES	[H]O[H].OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
CAS DataBase Reference	5989-81-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	EWQ57Q8I5X
EPA Substance Registry System	.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, hydrate (1:1) (5989-81-1)
UNSPSC Code	85151701
NACRES	NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

40-36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

Yes

HS Code

17021100

Storage Class

11 - Combustible Solids

NFPA 704

	1
1		0

Alpha-D-Lactose monohydrate price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	L2643	α-Lactose monohydrate suitable for cell culture, BioReagent	5989-81-1	5kg	$188	2026-04-30	Buy
Sigma-Aldrich	47287-U	Lactose Monohydrate analyticalstandard	5989-81-1	1kit	$27.8	2026-04-30	Buy
Biosynth	OL05009	a-Lactose monohydrate	5989-81-1	2kg	$176.52	2026-06-04	Buy
Biosynth	OL05009	a-Lactose monohydrate	5989-81-1	5kg	$363.45	2026-06-04	Buy
Biosynth	OL05009	a-Lactose monohydrate	5989-81-1	10kg	$687.9	2026-06-04	Buy

Product number	Packaging	Price	Buy
L2643	5kg	$188	Buy
47287-U	1kit	$27.8	Buy
OL05009	2kg	$176.52	Buy
OL05009	5kg	$363.45	Buy
OL05009	10kg	$687.9	Buy

Alpha-D-Lactose monohydrate Chemical Properties, Uses, Production

Chemical Properties

Lactose occurs as white to off-white crystalline particles or powder. It is odorless and slightly sweet-tasting. Spray-dried directcompression grades of lactose are generally composed of 80–90% specially prepared pure a-lactose monohydrate along with 10–20% of amorphous lactose.

Chemical Properties

White powder

Uses

alpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.

Definition

A sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.

Production Methods

A suspension of a-lactose monohydrate crystals in a lactose solution is atomized and dried in a spray drier. Approximately 10–20% of the total amount of lactose is in solution and the remaining 80–90% is present in the crystalline form. The spray-drying process predominantly produces spherical particles. The compactibility of the material and its flow characteristics are a function of the primary particle size of the lactose monohydrate and the amount of amorphous lactose.

Pharmaceutical Applications

Spray-dried lactose is widely used as a binder, filler-binder, and flow aid in direct compression tableting.

Biochem/physiol Actions

alpha-Lactose is the primary sugar present in milk and the main energy source to a newborn mammalian through its mother′s milk. It is digested by the intestinal lactase (EC 3.2.1.108), an enzyme expressed in newborns. The enzyme′s activity declines following weaning which can lead to lactose intolerance in adult mammals.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent in oral capsule and tablet formulations. It may also be used in intravenous injections.
Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the enzyme lactase.

storage

Spray-dried lactose should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Lactose is a reducing sugar. The amorphous lactose, which is the most reactive form of lactose present in spray-dried lactose, will interact more readily than conventional crystalline grades. Typical reactions include the Maillard reaction with either primary or secondary amines.

Alpha-D-Lactose monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Alpha-D-Lactose monohydrate Suppliers

Global Suppliers ( 394)

Supplier	Tel	Email	Country	ProdList	Advantage
AVT(Shanghai) Pharmaceutical Tech Co., Ltd.	021-58876118 15692161719	avt013@avt-cn.com	China	97	58
jinyang	18234787927	3056978024@qq.com	China	348	58
-xianqingyan	15339027915	2768604651@qq.com	China	280	58
Shaanxi Tangyao Biotechnology Co., Ltd.	18092657875 18091843347	2700724542@qq.com	China	188	58
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9409	55
Adamas Reagent, Ltd.	4006009262 13023226327	hmj@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7231	62

Supplier	Advantage
AVT(Shanghai) Pharmaceutical Tech Co., Ltd.	58
jinyang	58
-xianqingyan	58
Shaanxi Tangyao Biotechnology Co., Ltd.	58
Beijing HwrkChemical Technology Co., Ltd	55
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Sichuan Kulinan Technology Co., Ltd	57
Sinopharm Chemical Reagent Co,Ltd.	79
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62

View Latest Price from Alpha-D-Lactose monohydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-30	α-Lactose monohydrate 5989-81-1		25KG	98%-102%	20 tons	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	Alpha-D-Lactose monohydrate 5989-81-1	$1.00-8.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-03-20	Alpha-D-Lactose monohydrate 5989-81-1	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

α-Lactose monohydrate
5989-81-1
98%-102%
WUHAN FORTUNA CHEMICAL CO., LTD

Alpha-D-Lactose monohydrate
5989-81-1
$1.00-8.00
99%
Henan Fengda Chemical Co., Ltd

Alpha-D-Lactose monohydrate
5989-81-1
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Alpha-D-Lactose monohydrate Spectrum

Alpha-D-Lactose monohydrate(5989-81-1)¹HNMR Alpha-D-Lactose monohydrate(5989-81-1)IR Alpha-D-Lactose monohydrate(5989-81-1)Raman Alpha-D-Lactose monohydrate(5989-81-1)FT-IR

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alpha-D-Lactose Monohydrate, 99.5+%, 2-4% beta-isoMer alpha-D-Lactose Monohydrate, USP/NF, Ph.Eur., JP 250GR 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose monohydrate LACTOSE MONOHYDRATE, a-(RG) Pharmatose 325 Pharmatose 50M Pharmatose DCL 11 Zeparox ^a-D-Lactose Monohydrate, 97%, 97% alpha-D(+)-La BETA-D-GAL-(1->4)-ALPHA-D-GLC BETA-D-GAL-(1->4)-ALPHA-D-GLC, MONOHYDRATE LACTOSE, A- D(+)-LACTOSE HYDRATE D-(+)-LACTOSE HYDRATE,ALPHA-FORM ALPHA-D(+)-LACTOBIOSE MONOHYDRATE ALPHA-D-(+)-LACTOSE, HYDRATE ALPHA-D(+)-LACTOSE MONOHYDRATE ALPHA-D-LACTOSE MONOHYDRATE A-LACTOBIOSE ALPHA-LACTOSE MONOHYDRATE, BIOXTRA ALPHA-LACTOSE MONOHYDRATE,>=99% (GC) β-D-Gal-(1→4)-α-D-Glc 4-O-β-D-Galactopyranosyl-α-D-glucose 4-O-BETA-D-GALACTOPYRANOSYL-ALPHA-D-GLUCOSE 4-O-BETA-D-GALACTOPYRANOSYL-ALPHA-D-GLUCOSE MONOHYDRATE D-LACTOSE MONOHYDRATE A.C.S. REAGENT A-LACTOSE MONOHYDRATE CELL CULTURE*TESTE D LACTOSE MONOHYDRATE 500MG NEAT A-LACTOSE MONOHYDRATE SIGMAULTRA Α-D-LACTOSE MONOHYDRATE GR ACS Α-D-LACTOSE MONOHYDRATE 99.5+% Α-D-LACTOSE MONOHYDRATE USP NF PH.EUR.,JP beta-D-Gal-[1.4]-alpha-D-Glc.H2O alpha-D-Lactose monohydrate, 99.5+% 4-O-beta-d-Galactopyranosyl 4-O-beta-d-Galactopyranosyl-d-glucose alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrate Saccharum lactis alpha-D-Lactose monohydrate, USP/NF, Ph.Eur., JP alpha-D-Lactose, monohydrate, reagent ACS à-d-lactose monohydrate LACTOSE USP a-D-Lactose monohydrate β-D-Gal-(1-4)-α-D-Glc, Milk sugar, 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate, β-D-Gal-(1-4)-α-D-Glc, Milk sugar, 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate ,98% Lactose Monohydrate (500 mg) D -LACTOSE, ACS 4-O-β-D-Galactopyranosyl-α-D-glucose α-Lactose monohydrate, AR，≥98.0% (HPLC) 4-O-β-D-Galactopyranosyl-α-D-glucopyranose monohydrate (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol hydrate Alpha-D-Lactose monohydrate USP/EP/BP Lactose / anhydrous lactose Inhalac 120 (contains β anomer) alpha-D-Lactose 1-hydrate O4-β-D-galactopyranosyl-β-D-glucopyranose hydrate