ChemicalBook
Chinese Japanese Germany Korea

Lactose

Lactose
Lactose structure
CAS No.
63-42-3
Chemical Name:
Lactose
Synonyms
LACTIN;LACTOSE;Lactosum;D-LACTOSE;Galactinum;Aletobiose;Osmolactan;LACTOBIOSE;SUGAR MILK;MILK SUGAR
CBNumber:
CB8710411
Molecular Formula:
C12H22O11
Formula Weight:
342.3
MOL File:
63-42-3.mol

Lactose Properties

Melting point:
222.8°C
Boiling point:
397.76°C (rough estimate)
Density 
1.5300
refractive index 
1.5376 (estimate)
storage temp. 
2-8°C
storage temp. 
2-8°C
solubility 
Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
form 
Powder
pka
12.39±0.20(Predicted)
color 
White to Off-white
Water Solubility 
5-10 g/100 mL at 20 ºC
BRN 
93796
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
63-42-3(CAS DataBase Reference)
FDA 21 CFR
168.122; 169.179; 310.545
Substances Added to Food (formerly EAFUS)
LACTOSE
EWG's Food Scores
1
FDA UNII
13Q3A43E0S
NCI Dictionary of Cancer Terms
lactose
NIST Chemistry Reference
D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3)
EPA Substance Registry System
Lactose (63-42-3)
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  2
RTECS  OD9625000
TSCA  Yes
HS Code  17021100

Lactose price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17814 Lactose tested according to Ph.Eur. 63-42-3 1kg $167 2021-03-22 Buy
Sigma-Aldrich A1206000 Lactose (anhydrous) European Pharmacopoeia (EP) Reference Standard 63-42-3 $198 2021-03-22 Buy
Sigma-Aldrich 1356676 Anhydrous lactose United States Pharmacopeia (USP) Reference Standard 63-42-3 100mg $437 2020-08-18 Buy
Alfa Aesar J66376 D-Lactose 63-42-3 1kg $123 2021-03-22 Buy
Alfa Aesar J66376 D-Lactose 63-42-3 500g $69.3 2021-03-22 Buy

Lactose Chemical Properties,Uses,Production

Chemical Properties

white crystals or powder

Chemical Properties

Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose.

Uses

A disaccharide sugar present in milk.

Uses

Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent.

Production Methods

There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available.

Definition

A sugar found in milk. It is a disaccharide composed of glucose and galactose units.

Air & Water Reactions

Water soluble.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic.

Pharmaceutical Applications

Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections.

Safety

Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms.

storage

Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place.

Purification Methods

-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.]

Incompatibilities

Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Lactose Preparation Products And Raw materials

Raw materials

Preparation Products


Lactose Suppliers

Global( 287)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com CHINA 1596 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29955 58
Wuhan Boyuan Import & Export Co., LTD
+8618033787409
0311-89850048 Mike@whby-chem.com China 299 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5912 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

View Lastest Price from Lactose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Lactose
63-42-3
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-12-01 Lactose
63-42-3
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-12-01 Lactose
63-42-3
US $5.99 / KG 1KG 99% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd

63-42-3(Lactose)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved