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Lactose structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Lactose Properties

Melting point:
Boiling point:
397.76°C (rough estimate)
refractive index 
1.5376 (estimate)
storage temp. 
storage temp. 
Freely but slowly soluble in water, practically insoluble in ethanol (96 per cent).
White to Off-white
Water Solubility 
5-10 g/100 mL at 20 ºC
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
63-42-3(CAS DataBase Reference)
168.122; 169.179; 310.545
Substances Added to Food (formerly EAFUS)
EWG's Food Scores
NCI Dictionary of Cancer Terms
NIST Chemistry Reference
D-Glucose, 4-o-«beta»-D-galactopyranosyl-(63-42-3)
EPA Substance Registry System
Lactose (63-42-3)
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  2
RTECS  OD9625000
HS Code  17021100

Lactose price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17814 Lactose tested according to Ph.Eur. 63-42-3 1kg $167 2021-03-22 Buy
Sigma-Aldrich A1206000 Lactose (anhydrous) European Pharmacopoeia (EP) Reference Standard 63-42-3 $198 2021-03-22 Buy
Sigma-Aldrich 1356676 Anhydrous lactose United States Pharmacopeia (USP) Reference Standard 63-42-3 100mg $437 2020-08-18 Buy
Alfa Aesar J66376 D-Lactose 63-42-3 1kg $123 2021-03-22 Buy
Alfa Aesar J66376 D-Lactose 63-42-3 500g $69.3 2021-03-22 Buy

Lactose Chemical Properties,Uses,Production

Chemical Properties

white crystals or powder

Chemical Properties

Anhydrous lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous b-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70–80% anhydrous b-lactose and 20–30% anhydrous a-lactose.


A disaccharide sugar present in milk.


Lactose is a disaccharide carbohydrate that occurs in mammalian milk except that of the whale and the hippopotamus. it is princi- pally obtained as a cows’ milk derivative. it is also termed milk sugar and it is a reducing sugar consisting of glucose and galactose. its most common commercial form is alpha-monohydrate, with the beta-anhydride form available to a lesser extent. all forms in solution will equilibrate to a beta:alpha ratio of 62.25:37.75 at 0°c. it is about one-sixth as sweet as sugar and is less soluble. it functions as a flow agent, humectant, crystallization control agent, and sweetener. it is used in baked goods for flavor, browning, and tenderizing and in dry mixes as an anticaking agent.

Production Methods

There are two anhydrous forms of lactose: a-lactose and b-lactose. The temperature of crystallization influences the ratio of a- and blactose. The anhydrous forms that are commercially available may exhibit hygroscopicity at high relative humidities. Anhydrous lactose is produced by roller drying a solution of lactose above 93.5°C. The resulting product is then milled and sieved. Two anhydrous a-lactoses can be prepared using special drying techniques: one is unstable and hygroscopic; the other exhibits good compaction properties. However, these materials are not commercially available.


A sugar found in milk. It is a disaccharide composed of glucose and galactose units.

Air & Water Reactions

Water soluble.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Lactose should be considered toxic.

Pharmaceutical Applications

Anhydrous lactose is widely used in direct compression tableting applications, and as a tablet and capsule filler and binder. Anhydrous lactose can be used with moisture-sensitive drugs due to its low moisture content. It may also be used in intravenous injections.


Lactose is widely used in pharmaceutical formulations as a diluent and filler-binder in oral capsule and tablet formulations. It may also be used in intravenous injections. Adverse reactions to lactose are largely due to lactose intolerance, which occurs in individuals with a deficiency of the intestinal enzyme lactase, and is associated with oral ingestion of amounts well over those found in solid dosage forms.


Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80°C and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day.
Lactose anhydrous should be stored in a well-closed container in a cool, dry place.

Purification Methods

-Lactose crystallises from water below 93.5o as the hydrate which can be dried at 80o/14mm. [Horst Recl Trav Chim, Pays-Bas 72 878 1953, Beilst 17 III/IV 3066.]


Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degradation.
Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine groups.
Lactose anhydrous is a reducing sugar with the potential to interact with primary and secondary amines (Maillard reaction) when stored under conditions of high humidity for extended periods.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IM, IV: powder for injection solution; IV and sublingual preparations; oral: capsules and tablets; powder for inhalation; vaginal). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Lactose Preparation Products And Raw materials

Raw materials

Preparation Products

Lactose Suppliers

Global( 287)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Xi'an ZB Biotech Co.,Ltd
+8618591943808 CHINA 1596 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
career henan chemical co
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Wuhan Boyuan Import & Export Co., LTD
0311-89850048 China 299 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5912 58
Chongqing Chemdad Co.,Ltd
+86-19923101450 CHINA 4000 58

View Lastest Price from Lactose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Lactose
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-12-01 Lactose
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-12-01 Lactose
US $5.99 / KG 1KG 99% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd

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