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Glycyrrhizic acid

CAS No.
1405-86-3
Chemical Name:
Glycyrrhizic acid
Synonyms
GLYCYRRHIZIN;GLYCYRRHIZINATE;18β-Glycyrrhizic acid;Deglycyrrhizinated Licorice;liquorice;Glycyrrhizic acid 1405-86-3;Glycyrrhizine;Glycyrrhizic;glycyrrhizic acid A;glycyron
CBNumber:
CB0482721
Molecular Formula:
C42H62O16
Molecular Weight:
822.94
MDL Number:
MFCD00065194
MOL File:
1405-86-3.mol
Modify Date:2022-11-11 13:01:00

Glycyrrhizic acid Properties

Melting point 220°C (rough estimate)
Boiling point 681.01°C (rough estimate)
alpha D17 +46.2° (c = 1.5 in alc)
Density 1.1442 (rough estimate)
refractive index 61 ° (C=1.5, EtOH)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly)
form Solid
pka 2.76±0.70(Predicted)
color White to Light Yellow
Merck 14,4505
Stability Hygroscopic
InChIKey BXFBITNYMHAJGT-KYXJNIQISA-N
CAS DataBase Reference 1405-86-3
SCOGS (Select Committee on GRAS Substances) Licorice
FDA UNII 6FO62043WK
ATC code A05BA08
EPA Substance Registry System Glycyrrhizin (1405-86-3)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
RTECS  MD2025000
HS Code  29389090

Glycyrrhizic acid price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1516 Glycyrrhizic acid 1405-86-3 200mg $160 2022-05-15 Buy
Sigma-Aldrich 1295888 Glycyrrhizic acid 1405-86-3 25mg $1020 2022-05-15 Buy
TCI Chemical G0150 Glycyrrhizin >93.0%(T) 1405-86-3 1g $41 2022-04-27 Buy
TCI Chemical G0150 Glycyrrhizin >93.0%(T) 1405-86-3 25g $233 2022-04-27 Buy
Usbiological 300375 Glycyrrhizic acid 1405-86-3 20mg $276 2021-12-16 Buy
Product number Packaging Price Buy
PHR1516 200mg $160 Buy
1295888 25mg $1020 Buy
G0150 1g $41 Buy
G0150 25g $233 Buy
300375 20mg $276 Buy

Glycyrrhizic acid Chemical Properties,Uses,Production

Description

Glycyrrhizic acid is a kind of anti-inflammatory triterpene glycoside extracted from the licorice root. Inside the body, it can be metabolized to glycyrrhetinic acid which inhibits the 11-beta-hydroxysteroid dehydrogenase and some other enzymes related to the corticosteroid metabolism. Glycyrrhizic acid has various pharmacological effects including suppressing hepatic apoptosis and necrosis, anti-inflammatory and immune regulatory actions, antiviral effects, antineoplastic and anticancer effects. It is the active ingredient of licorice root which is commonly used in the treatment of acute and chronic liver injury, viral hepatitis, hepatic steatosis, liver fibrosis, hepatoma, viral myocarditis and other diseases such as psoriasis or prostate cancer. Glycyrrhizic acid is also widely used as a sweetening and flavoring agent in food.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhizic_acid#section=Top

Chemical Properties

White to off-white powder

Chemical Properties

Glycyrrhizin, also known as glycyrrhizic acid, is a glycoside isolated from the roots of licorice, Glycyrrhiza glabra L. For improved water solubility, an ammoniated salt is commonly used. This can be in the form of either ammonium glycyrrhizinate or monoammonium glycyrrhizinate.

Uses

Glycyrrhizic acid is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects.

Uses

Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement.

Uses

11beta-hydroxysteroid dehydrogenase inhibitor, antiinflammatory, expectorant, antihaemorrhagic, anti-HIV

Uses

glycyrrhizic acid is a hydrolyzed glycyrrhizin. It is credited with antiinflammatory and anti-allergenic properties. Studies comparing glycyrrhizin with hydrocortisone found glycyrrhizin to be somewhat milder but longer lasting in effectiveness. once the application of hydrocortisone is suspended, the symptoms return. This does not appear to be the case with glycyrrhizin. It does not have side effects and is chemically stable so it can be safely used on a continuing basis.

Definition

ChEBI: A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence and changes in the metabolism of phosphorus, When heated to decomposition it emits acrid smoke and irritating fumes.

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View Lastest Price from Glycyrrhizic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Glycyrrhizic acid pictures 2022-12-08 Glycyrrhizic acid
1405-86-3
US $5.00 / kg 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd
Glycyrrhizic acid pictures 2022-12-08 Glycyrrhizic acid
1405-86-3
US $0.00 / KG 1KG ≥98% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Glycyrrhizinic Acid pictures 2022-11-02 Glycyrrhizinic Acid
1405-86-3
US $15.00-10.00 / kg 1kg 99% 5Tons Hebei Shengyuan Jinlong Import and Export Co. LTD
  • Glycyrrhizic acid pictures
  • Glycyrrhizic acid
    1405-86-3
  • US $0.00 / KG
  • ≥98% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Glycyrrhizinic Acid pictures
  • Glycyrrhizinic Acid
    1405-86-3
  • US $15.00-10.00 / kg
  • 99%
  • Hebei Shengyuan Jinlong Import and Export Co. LTD
3-o-(2-o-beta-d-glucopyranuronosyl-alpha-d-glucopyranuronosyl)-18beta-g lycyrrhetinic acid Glycyrrhisinic acid power 21% W/W Glycyrrhizinate acid 15-18% (R-19) Glycyrrhizin std. .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl- Potassium Glycyrrhetate Glycyrrhizic acid (8CI) NSC 167409 NSC 234419 Potenlini α-D-Glucopyranosiduronic acid, (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl- glucopyranuronosyl-.alpha.-D-Glucopyranosiduronic acid DerMacrin Glycyrrhitin Of glycyrrhizin Radix Glycyrrhizae Glycyrrhizin (Glycyrrhizic Acid) Glycyrrhizic acid 3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid Glycyrrhizic acid, >=98% (3β,18α)-30-hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-β-D-glucopyranosiduronic acid Glycyrrhizic Acid 〔Glycyrrhizin〕 18-beta-glycyrrhizicacid 20beta-carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-o-beta-d-glucopyranuronosyl -alpha-d-glucopyranosiduronicacid alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norol alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norolean beta-glycyrrhizin ean-12-en-3-yl2-o-beta-d-glucopyranuronosyl- glycyrrhizinicacid carboxy-11-oxo-30- norolean-12-en-3-yl 2-O-β-D- glucopyranuronosyl- β-D-Glucopyranosiduronic acid, (3β,20β)-20- (3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1- 7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid 30-Noroleanane, a-D-glucopyranosiduronic acid deriv. a-D-Glucopyranosiduronic acid, (3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl- (20S)-3β-[(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxoolean-12-en-30-oic acid GLYCYRRHIZIC ACID(P)(CALL) Glycyrrhizic Acid (25 mg) GLYCYRRHIZIC ACID(P) 5-[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]-6-[(11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy]-3,4-dihydroxyoxane-2-carboxylic acid (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-.alpha.-D-Glucopyranosiduronicacid -12-en-3-yl-2-o-beta-d-glucopyranuronosyl- (3β,20β)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-Glucopyranuronosyl-α- D-glucopyranosiduronic Acid Glycyrrhizinic acid (Glycyrrhizin) GLYCYRRHYCIC ACID GLYCYRRHIZIC ACID Glycyrrhizic acid, 98%, from Glycyrrhiza uralensis Fisch. Gross Glycyrrhizic Acid Glycyrrhizinic Glycyrrhizin sodium Glycyrrhizic Acid Standard Glycyrrhizic Acid RS Glycyrrhizin> Glycyrrizinicacid Glycyrrhizic acid fandachem glycyrrhizinicaci Glycyrrhizic acid USP/EP/BP