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Glycyrrhizic acid

Description References
Glycyrrhizic acid
Glycyrrhizic acid structure
CAS No.
1405-86-3
Chemical Name:
Glycyrrhizic acid
Synonyms
glycyron;Potenlini;DerMacrin;liquorice;NSC 167409;NSC 234419;GLYCYRRHIZIN;Glycyrrhizic;Glycyrrhitin;Glycyrrhizine
CBNumber:
CB0482721
Molecular Formula:
C42H62O16
Formula Weight:
822.94
MOL File:
1405-86-3.mol

Glycyrrhizic acid Properties

Melting point:
220°C (rough estimate)
Boiling point:
681.01°C (rough estimate)
alpha 
D17 +46.2° (c = 1.5 in alc)
Density 
1.1442 (rough estimate)
refractive index 
61 ° (C=1.5, EtOH)
storage temp. 
Inert atmosphere,2-8°C
pka
2.76±0.70(Predicted)
Merck 
14,4505
InChIKey
BXFBITNYMHAJGT-KYXJNIQISA-N
SCOGS (Select Committee on GRAS Substances)
Licorice
CAS DataBase Reference
1405-86-3
FDA UNII
6FO62043WK
EPA Substance Registry System
Glycyrrhizin (1405-86-3)
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
RTECS  MD2025000
HS Code  29389090

Glycyrrhizic acid price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1516 Glycyrrhizic acid 1405-86-3 200mg $137 2021-03-22 Buy
Sigma-Aldrich 1295888 Glycyrrhizic acid 1405-86-3 25mg $951 2021-03-22 Buy
TCI Chemical G0150 Glycyrrhizin >93.0%(T) 1405-86-3 1g $35 2021-03-22 Buy
TCI Chemical G0150 Glycyrrhizin >93.0%(T) 1405-86-3 25g $202 2021-03-22 Buy

Glycyrrhizic acid Chemical Properties,Uses,Production

Description

Glycyrrhizic acid is a kind of anti-inflammatory triterpene glycoside extracted from the licorice root. Inside the body, it can be metabolized to glycyrrhetinic acid which inhibits the 11-beta-hydroxysteroid dehydrogenase and some other enzymes related to the corticosteroid metabolism. Glycyrrhizic acid has various pharmacological effects including suppressing hepatic apoptosis and necrosis, anti-inflammatory and immune regulatory actions, antiviral effects, antineoplastic and anticancer effects. It is the active ingredient of licorice root which is commonly used in the treatment of acute and chronic liver injury, viral hepatitis, hepatic steatosis, liver fibrosis, hepatoma, viral myocarditis and other diseases such as psoriasis or prostate cancer. Glycyrrhizic acid is also widely used as a sweetening and flavoring agent in food.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhizic_acid#section=Top

Chemical Properties

White to off-white powder

Chemical Properties

Glycyrrhizin, also known as glycyrrhizic acid, is a glycoside isolated from the roots of licorice, Glycyrrhiza glabra L. For improved water solubility, an ammoniated salt is commonly used. This can be in the form of either ammonium glycyrrhizinate or monoammonium glycyrrhizinate.

Uses

Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement.

Uses

glycyrrhizic acid is a hydrolyzed glycyrrhizin. It is credited with antiinflammatory and anti-allergenic properties. Studies comparing glycyrrhizin with hydrocortisone found glycyrrhizin to be somewhat milder but longer lasting in effectiveness. once the application of hydrocortisone is suspended, the symptoms return. This does not appear to be the case with glycyrrhizin. It does not have side effects and is chemically stable so it can be safely used on a continuing basis.

Uses

11beta-hydroxysteroid dehydrogenase inhibitor, antiinflammatory, expectorant, antihaemorrhagic, anti-HIV

Uses

Glycyrrhizic acid is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects.

Definition

ChEBI: A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence and changes in the metabolism of phosphorus, When heated to decomposition it emits acrid smoke and irritating fumes.

Glycyrrhizic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Glycyrrhizic acid Suppliers

Global( 418)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
SINOPRO.CO.LTD
0082-42-721-7177
0082-42-3676760 michael@sinopro.co.kr South Korea 300 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58

View Lastest Price from Glycyrrhizic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Glycyrrhizic acid
1405-86-3
US $10.00-88.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-20 Glycyrrhizic acid
1405-86-3
US $78.00-65.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 Glycyrrhizic acid
1405-86-3
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd

Glycyrrhizic acid Spectrum


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