1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- CAS No.
- 1147-56-4
- Chemical Name:
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
- Synonyms
- TAN;ERGi-USU;NSC139021;Nitrilotantalum(III);NSC139021 (ERGi-USU);ERGi-USU (NSC139021);1-(2’-Thiazolylazo)-β-naphtho;1-(2-THIAZOLYLAZO)-2-NAPHTHOL;1-(thiazol-2-ylazo)-2-naphthol;1-(2'-Thiazolylazo)-β-naphthol
- CBNumber:
- CB0321974
- Molecular Formula:
- C13H9N3OS
- Molecular Weight:
- 255.3
- MDL Number:
- MFCD00021611
- MOL File:
- 1147-56-4.mol
- MSDS File:
- SDS
Melting point | 138-139 °C |
---|---|
Boiling point | 464.8±47.0 °C(Predicted) |
Density | 1.40 |
storage temp. | 2-8°C |
solubility | methanol: 10 mg/mL, clear |
pka | 8.71±0.50(Predicted) |
form | solid |
color | Red or orange |
BRN | 223783 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
CAS DataBase Reference | 1147-56-4(CAS DataBase Reference) |
EPA Substance Registry System | 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HS Code | 2927.00.5000 | |||||||||
NFPA 704 |
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1-(2-THIAZOLYLAZO)-2-NAPHTHOL price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | A5003 | TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals] >99.0%(T) | 1147-56-4 | 1g | $72 | 2024-03-01 | Buy |
TCI Chemical | A5003 | TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals] >99.0%(T) | 1147-56-4 | 5g | $246 | 2024-03-01 | Buy |
Alfa Aesar | B24011 | 1-(2-Thiazolylazo)-2-naphthol, 98% | 1147-56-4 | 1g | $32.65 | 2024-03-01 | Buy |
Alfa Aesar | B24011 | 1-(2-Thiazolylazo)-2-naphthol, 98% | 1147-56-4 | 5g | $103.65 | 2024-03-01 | Buy |
Alfa Aesar | B24011 | 1-(2-Thiazolylazo)-2-naphthol, 98% | 1147-56-4 | 25g | $409.65 | 2024-03-01 | Buy |
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties,Uses,Production
Description
ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
Uses
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
storage
Store at +4°C
References
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-THIAZOLYLAZO)-2-NAPHTHOL Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | cherry@crovellbio.com | China | 18421 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 12272 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from 1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-17 | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
|
US $0.00-0.00 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
2021-08-12 | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-02 | TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
1147-56-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
- 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1147-56-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- TAN [=1-(2-Thiazolylazo)-2-naphthol][Spectrophotometric reagent for transition metals]
1147-56-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd