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6-Chloroindole-2-carboxylic acid ethyl ester

6-Chloroindole-2-carboxylic acid ethyl ester Structure
6-Chloroindole-2-carboxylic acid ethyl ester structure
CAS No.
27034-51-1
Chemical Name:
6-Chloroindole-2-carboxylic acid ethyl ester
Synonyms
SPECS AP-283/40634148;6-CHLORO-2-INDOLECARBOXYLIC;Ethyl 6-chloroindole-2-carboxylate;Ethyl 6-Chloroindole-2-Carboxylicate;Ethyl 6-chloro-1H-indole-2-caboxylate;Ethyl6-chloroindole-2-carboxylate,97%;Ethyl 6-chloro-1H-indol-2-carboxylate;ETHYL 6-CHLORO-1H-INDOLE-2-CARBOXYLATE;6-CHLORO-2-INDOLECARBOXYLIC METHYL ESTER;6-Chlor-indol-2-carbonsaeure-aethylester
CBNumber:
CB0342977
Molecular Formula:
C11H10ClNO2
Molecular Weight:
223.66
MDL Number:
MFCD03084731
MOL File:
27034-51-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-11-04 16:52:46
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6-Chloroindole-2-carboxylic acid ethyl ester Properties

Melting point 169-171 °C
Boiling point 375.0±22.0 °C(Predicted)
Density 1.329±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Solid
pka 14.11±0.30(Predicted)
Appearance Light brown to gray Solid
CAS DataBase Reference 27034-51-1(CAS DataBase Reference)
Comptox DTXSID DTXSID80426709

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2933998090
NFPA 704
1
2 0

6-Chloroindole-2-carboxylic acid ethyl ester price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR350473 Ethyl 6-Chloroindole-2-carboxylate 98% 27034-51-1 250mg $21 2026-06-04 Buy
Apolloscientific OR350473 Ethyl 6-Chloroindole-2-carboxylate 98% 27034-51-1 1g $24 2026-06-04 Buy
Apolloscientific OR350473 Ethyl 6-Chloroindole-2-carboxylate 98% 27034-51-1 5g $36 2026-06-04 Buy
Apolloscientific OR350473 Ethyl 6-Chloroindole-2-carboxylate 98% 27034-51-1 25g $169 2026-06-04 Buy
Apolloscientific OR350473 Ethyl 6-Chloroindole-2-carboxylate 98% 27034-51-1 100g $581 2026-06-04 Buy
Product number Packaging Price Buy
OR350473 250mg $21 Buy
OR350473 1g $24 Buy
OR350473 5g $36 Buy
OR350473 25g $169 Buy
OR350473 100g $581 Buy

6-Chloroindole-2-carboxylic acid ethyl ester Chemical Properties, Uses, Production

Uses

Ethyl 6-chloroindole-2-carboxylate is an organic compound mainly used as a pharmaceutical intermediate and chemical reagent.

Synthesis

2-Propenoic acid, 2-azido-3-(4-chlorophenyl)-, ethyl ester, (2Z)-

24513-05-1

6-Chloroindole-2-carboxylic acid ethyl ester

27034-51-1

General method: 6a-d (9.2 mmol) was dissolved in toluene (150 mL) under nitrogen protection, rhodium(II) acetate dimer (203 mg, 0.46 mmol) was added, and the reaction was heated to reflux for 1-2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 25:1 to 18:1, v/v) to afford the target product ethyl 6-chloroindole-2-carboxylate (7a-d) in 51.7%-58.6% overall yields.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1760 - 1762
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 4, p. 1283 - 1292

6-Chloroindole-2-carboxylic acid ethyl ester synthesis

7439-89-6
540523-98-6
27034-51-1
Synthesis of 6-Chloroindole-2-carboxylic acid ethyl ester from Iron and Ethyl 3-(4-chloro-2-nitrophenyl)-2-oxopropanoate

6-Chloroindole-2-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Ethanol Diethyl oxalate Diethyl ether Hydrochloric acid Acetic acid
Potassium 4-Chloro-2-nitrotoluene Ethyl 3-(4-chloro-2-nitrophenyl)-2-oxopropanoate (Z)-4-(4-Chlorobenzylidene)-2-methyloxazol-5(4H)-one ethyl 2-ethoxy acrylate
3-Chlorophenylhydrazine hydrochloride Ethyl-4-Chloroindole-2-Carboxylate 5-Chloro-2-iodoaniline 4-Chloro-2-nitrobenzaldehyde Iron
3-Chloroaniline

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Preparation Products

6-Chloroindole-2-carboxylic acid ethyl ester Suppliers

Global Suppliers ( 148)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 995 56
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11771 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 15343 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Carbott PharmTech Inc. 56
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 6-Chloroindole-2-carboxylic acid ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Chloroindole-2-carboxylic acid ethyl ester pictures 2021-08-12 6-Chloroindole-2-carboxylic acid ethyl ester
27034-51-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
6-Chloroindole-2-carboxylic acid ethyl ester pictures 2020-01-15 6-Chloroindole-2-carboxylic acid ethyl ester
27034-51-1
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

6-Chloroindole-2-carboxylic acid ethyl ester Spectrum

6-Chloroindole-2-carboxylic acid ethyl ester(27034-51-1)1HNMR

27034-51-1 (6-Chloroindole-2-carboxylic acid ethyl ester) Related Search:

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6-Chloroindole Ethyl chloroacetate Ethylparaben Indole-2-carboxylic acid Diethyl chloromalonate
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SPECS AP-283/40634148 6-CHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER 6-Chloroindole-2-Carboxylic Acid Ethyl Acid Ethyl 6-chloroindole-2-carboxylate 6-CHLORO-2-INDOLECARBOXYLIC METHYL ESTER Ethyl 6-Chloroindole-2-Carboxylicate 6-CHLORO-2-INDOLECARBOXYLIC 6-Chloroindole-2-carboxylic acid ethyl ester ,99% 1H-Indole-2-carboxylic acid, 6-chloro-, ethyl ester 6-Chloro-1H-indole-2-carboxylic acid ethyl ester Ethyl 6-chloro-1H-indole-2-caboxylate 6-Chlor-indol-2-carbonsaeure-aethylester 6-chlorindole-2-carboxylic acid ethyl ester Ethyl6-chloroindole-2-carboxylate,97% 1H-Indole-2-carboxylic acid, 6-chloro-, ethyl ester (9CI, ACI) 6-chloro-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI) 6-Chloroindole-2-carboxylic acid ethyl ester?New ETHYL 6-CHLORO-1H-INDOLE-2-CARBOXYLATE Ethyl 6-chloro-1H-indol-2-carboxylate 27034-51-1 C11H10ClNO2 Indole/indoline/oxindole Indole and Indoline Indole Indoles