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Indications and Usage Mechanisms of Action Pharmacokinetics Adverse reactions Contradictions Warnings and Precautions
Oxytocin structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Oxytocin Properties

Melting point:
D22 -26.2° (c = 0.53)
1.1086 (rough estimate)
refractive index 
1.6700 (estimate)
storage temp. 
Very soluble in water. It dissolves in dilute solutions of acetic acid and of ethanol (96 per cent).
lyophilized powder
pKa ~6.1(free amino group on Cys) (Occasionally);~10(free phenol on Tyr) (Occasionally)
Water Solubility 
Soluble in water.
CAS DataBase Reference
50-56-6(CAS DataBase Reference)
  • Risk and Safety Statements
Hazard statements  H300-H361
Precautionary statements  P201-P280-P301+P310a-P308+P313-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  RS7534000
HazardClass  6.1(a)
PackingGroup  II
HS Code  2937190000
Toxicity LD50 oral in rat: > 20520ug/kg

Oxytocin price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O3251 Oxytocin ≥97% (HPLC) 50-56-6 500iu $45.8 2018-11-20 Buy
Sigma-Aldrich 900169 Oxytocin ≥98 atom % D, ≥95% (CP) 50-56-6 1mg $515 2018-11-20 Buy
Alfa Aesar J63421 Oxytocin, 96% 50-56-6 25mg $590 2018-11-13 Buy
Alfa Aesar J63421 Oxytocin, 96% 50-56-6 5mg $154 2018-11-13 Buy
Cayman Chemical 11799 Oxytocin ≥98% 50-56-6 5mg $152 2018-11-13 Buy

Oxytocin Chemical Properties,Uses,Production

Indications and Usage

Oxytocin (OT) is a type of uterine contraction drug and can be derived from the animal posterior pituitary or chemically synthesized.
Oxytocin is a uterine contraction drug that is mostly used in late pregnancy induction and stagnant birth due to weak uterine contractions. Suitable for inducing labor and alleviating pain. Commonly used with ergot preparations to be used in inducing labor, expediting labor, and in uterine bleeding due to weak uterine contractions following birth or still birth. Nose drops can be used to promote lactation.

Mechanisms of Action

Oxytocin does not contain vasopressin and has no pressure-boosting effects. It can be absorbed through oral mucosa, selectively excite smooth uterine muscle, and intensify its contractions. The uterus is most sensitive to oxytocin when in labor (due to increased estrogen secretion), and an immature uterus will not respond to this drug. During early or mid-term pregnancy, the uterus has a relatively low reactivity to oxytocin, which gradually increases during late-stage pregnancy and peaks during labor. Small doses can strengthen the rhythmic contractions of smooth uterine muscles, increase their contractibility, increase their contraction speed, ensure similar contraction characteristics to that of a natural birth, and maintain polarity and symmetry. Thus, it is used clinically to expedite and induce labor. Large doses cause tonic contractions in the uterine muscles, so it is used clinically to burst blood vessels between muscle fibers, prevent postpartum hemorrhage, and ensuring postpartum recovery. It can also promote lactation by causing the breast ducts to contract and expel milk from the breasts, but it cannot increase the lactation amount.


Ineffective when taken orally, as it can be damaged by digestive fluids, although it can be absorbed through oral mucosa. 1-3 minutes of venous infusion 0.01 IU can induce physiological uterine contractions (Rhythmic, polar, symmetrical) with a short time span, as its half-life is only 2.5-3 minutes. Large doses cause tonic uterine contractions.

Adverse reactions

Oxytocin derived from cow or pig’s pituitary occasionally causes allergic reactions, and infusing too quickly may lead to mild vasodilation and hypotension. Patients who suffer from abruptio placentae, heart disease, or enlarged uterus, are over 35 years old, have a history of cesarean section or uterine muscle tumor removal, or are experiencing a breech birth should use with caution. Using oxytocin while experiencing a sacral block may lead to severe hypertension and even cerebrovascular rupturing. Cannot be injected in the same solution with norepinephrine. Incompatible with hydrolyzed proteins.


Do not use during birth if there are obvious signs of an unsymmetrical head, incorrect fetal position, exposed umbilical cord, prolapse, complete placenta previa, narrow pelvis, or overly intense uterine contractions. Not to be used by patients with overly narrow pelvises, histories of uterine surgery (including C-sections), excessive pains, blocked birth canals, abruptio placentae, or pregnancy poisoning.

Warnings and Precautions

Dosage and infusion speed must be strictly monitored when used to expedite or induce labor to prevent tonic contractions, which can suffocate the fetus or rupture the uterus.

Chemical Properties

White Solid


Oxytocin is the principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.


Oxytocin is a nonapeptide hormone primarily synthesized in magnocellular neurons of the paraventricular and supraoptic nuclei of the hypothalamus. It is known best for its role in stimulating uterine contraction and lactation and is important for social memory and attachment, sexual and maternal behavior, and aggression. Also, it has been implicated in various non-social behaviors, including learning, anxiety, feeding, and pain perception.


ChEBI: A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is bel eved to influence social cognition and behaviour.

brand name

Pitocin (Parkdale); Syntocinon (Novartis);Oxytocin;Pituitrin.

Veterinary Drugs and Treatments

In veterinary medicine, oxytocin has been used for induction or enhancement of uterine contractions at parturition, treatment of postpartum retained placenta and metritis, uterine involution after manual correction of prolapsed uterus in dogs, and in treating agalactia.

Purification Methods

It is a cyclic nonapeptide which is purified by countercurrent distribution between solvent and buffer. It is soluble in H2O, n-BuOH and isoBuOH. [Bodanszky & du Vigneaud J Am Chem Soc 81 2504 1959, Cash et al. J Med Pharm Chem 5 413 1962, Sakakibara et al. Bull Chem Soc Jpn 38 120 1965; solid phase synthesis: Bayer & Hagenmyer Tetrahedron Lett 2037 1968.] It was also synthesised on a solid phase matrix and finally purified as follows: A Sephadex G-25 column is equilibrated with the aqueous phase of a mixture of 3.5% AcOH (containing 1.5% of pyridine)/n-BuOH/*C6H6 (2:1:1) and then the organic phase of this mixture is run through. A solution of oxytocin (100mg) in H2O (2mL) is applied to the column which is then eluted with the organic layer of the above mixture. The fractions containing the major peak [as determined by the Folin-Lowry protein assay: Fryer et al. Anal Biochem 153 262 1986] are pooled, diluted with twice their volume of H2O, evaporated to a small volume and lyophilised to give oxytocin as a pure white powder (20mg, 508 U/mg). [Ives Can J Chem 46 2318 1968, Beilstein 22 III/IV 82.]

Oxytocin Preparation Products And Raw materials

Raw materials

Preparation Products

Oxytocin Suppliers

Global( 270)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Cellmano Biotech Limited
+86-551-65326641 CHINA 1044 58
18315825527 CHINA 19 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042693 China 921 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21667 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028 CHINA 272 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2911 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60

View Lastest Price from Oxytocin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-10-20 50-56-6
US $1.00 / kit 1kit 99.9% 200 GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
2019-10-20 Oxytocin
US $1.00 / kit 1kit 99.9% 200 GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
2019-07-05 Oxytocin
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

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