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Neomycin sulfate

Neomycin sulfate
Neomycin sulfate structure
CAS No.
1405-10-3
Chemical Name:
Neomycin sulfate
Synonyms
neomix;Myacine;Neosulf;Dentargle;neofracin;neobiotic;mycigient;bykomycin;otobiotic;usafcb-19
CBNumber:
CB0769897
Molecular Formula:
C23H48N6O17S
Formula Weight:
712.72
MOL File:
1405-10-3.mol

Neomycin sulfate Properties

Melting point:
>187°C (dec.)
alpha 
D20 +54° (c = 2 in H2O)
refractive index 
56 ° (C=10, H2O)
Flash point:
56℃
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
form 
powder
color 
white to slightly yellow
PH
5.0-7.5 (50g/l, H2O, 20℃)
Water Solubility 
Soluble in water
Merck 
14,6454
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
OIXVKQDWLFHVGR-VTSVPHRWSA-N
FDA 21 CFR
558.365; 558.4
CAS DataBase Reference
1405-10-3(CAS DataBase Reference)
EWG's Food Scores
3
FDA UNII
057Y626693
Proposition 65 List
Neomycin Sulfate (internal use)
EPA Substance Registry System
Neomycin sulfate (1405-10-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P280g-P342+P311a-P501a-P261-P280-P342+P311-P284-P304+P340
Hazard Codes  Xn,Xi
Risk Statements  42/43-22
Safety Statements  23-36/37-45-22-36-24/25
WGK Germany  3
RTECS  QP4375000
8
TSCA  Yes
HS Code  29419000
Toxicity LD50 oral in mouse: > 8gm

Neomycin sulfate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33492 Neomycin trisulfate salt hydrate VETRANAL 1405-10-3 100mg-r $36.4 2020-08-18 Buy
Sigma-Aldrich 1.06254 Neomycin sulfate for biochemistry 1405-10-3 100 g $150 2021-03-22 Buy
Sigma-Aldrich N0400000 Neomycin sulphate European Pharmacopoeia (EP) Reference Standard 1405-10-3 $190 2021-03-22 Buy
Sigma-Aldrich N0401000 Neomycin sulfate, for microbiological assay European Pharmacopoeia (EP) Reference Standard 1405-10-3 $190 2021-03-22 Buy
Sigma-Aldrich 1458009 Neomycin sulfate 1405-10-3 200mg $371 2020-08-18 Buy

Neomycin sulfate Chemical Properties,Uses,Production

Chemical Properties

NEOMYCIN SULFATE is  white or yellowish-white powder, hygroscopic.

Uses

NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Uses

NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.

Uses

Neomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use.

Indications

This drug is obtained from species of the actinomycete Streptomyces and is an aminoglycoside antibiotic (as are streptomycin, gentamicin, and kanamycin) effective against most aerobic gram-negative organisms. Group A streptococci are relatively resistant. Neomycin acts to inhibit bacterial protein synthesis by irreversibly binding to the 30S subunit. It is responsible for a greater incidence of allergic contact sensitivity than any other topical antibiotic. This diagnosis often remains hidden, because morphologically the eruption is of a mild eczematous nature. Rarely, anaphylaxis may occur.

brand name

Mycifradin (Pharmacia & Upjohn); Neo-Fradin (X Gen); Neobiotic (Pfizer);Abilene;Akentect;Amcort;Amphocort;Antibitulle;Apokalin;Aurex;Auriod;Baneopol;Barriere-mycin;Bastu-angin;Bedermin 100;Bio hubber;Biodry;Biofradin;Biofur;Biosol-m;Bio-vitastrept;Bivacyn;Bykanula;Canaural;Canoral;Cebemyxine;Cefrocyn;Cg 3224;Cicatrex;Cleniderm;Conderm;Conjuctilone;Cornemin;Cortinen;Damapo;Davimycin;Degramycin;Derbitan antibiotico;Dermicema;Dermo sonerge;Dermoface;Dermosan;Dermovate-nn;Derobion;Dexaamisolone-n;Dexabiotan;Dexacidin;Dexamist;Dexavetaderm;Dia-ject;Diarest;Dienterol;Dimicina;Doreplaston/doser/f;Dorithicin;Dulcicortine;Duphacerate;Dv 201;Emcortina;Emorex k berna;Enbacin;Enteromac;Enteropast;Enterosintex;Eustoporin;Febrizene;Fissan;Fl 6321 n;Flogocid;Fml-neo-liquifilm;Foille;Forbesotic;Formula 888;Forticillin;Fradyl;Frakidex;Frakitacine;Gastromycin;Gregoderm;Gustibon;H plus n;Hagrosept;Halicomb;Heliomycort;Hydrocortiderm;Hydro-neo oculos;I-caps;Idepa;Ido-op;Intradermo caf;Iodentero0neomicina;Itro;Jenomycin;Kaomycin;Kaopectate n;Kortikiod mepha;Lanbiotic;Larmicin;Latodurin;Linitut;Mammanopen;Mastrinal;Medisec neo;Medisec-cloxa;Medri-biotic;Meimyd;Menaderm antiacne;Mycerin;Mycidex;Mycimist;Mycipo;Mytrex;Nasomixin;Naso-neomicin;Nasydrin;Nefluan;Neimicina roger;Neo decaderm;Neo-analsona;Neoaristovet;Neobacimyx-h;Neobicin;Neobristan;Neo-cantil;Neocidin;Neocillin;Neoclox;Neocones;Neodecasone;Neo-delta-cortef;Neofluid;Neo-hydro;Neointestin;Neomac;Neo-mantle;Neo-mastitar;Neomycane;Neo-myx;Neo-otosol-hc;Neopec;Neopenol;Neopt;Neo-remusin;Neostrep;Neosule;Nifuramicin;Nisocla;Nisoclyn;Nisodyn;Nodryl;Nokamycin;Noperil;Ophthlmycin;Optiprime opthcoat;Optisone;Oribiotic;Oterna;Oticair;Oto vitna;Otocortison;Oto-flunal;Otomycin;Oto-sinerbe;Panotile;Parkeole;Parkesteron;Pentalmicina;Pervet;Phytacorcin;Polemycin;Polybactrin-g;Polygynax;Poly-pred;Polyspecrin;Porcijec;Prednicidin;Prevotec;Propaderm-n;Pulveodil;Pyocidin hc;Renokab;Rino vitna;Rinofilax;Rinojet;Rovicine;Saleton;Salvacolina nn;Sanibiovit;Sanimix;Sanistress;Secantol;Septomixine forte;Silderm;Siquent neomycin;Sofan;Sorbitoxin;Spersapolymyxin dispersa;Steros-anal;S-thalmic;Stiedex;Sulfix-6;Super masticort;Super mastitare;Synalar polyvalent;Syralbina;Tampovagan;Tariston;Telestyl;Tiframild;Tobispray;Topitasico;Tresaderm;Tribiotic;Tri-bow;Tricilone;Tri-optics;Troc;Tweenal;Ubrocelan;Uniriod;Uro-beniktol;Uro-nebctin;Varicella-rit;V-cortanmycetine;Vetroyl;Vetsovate;Vista-methasone n;V-softa.

World Health Organization (WHO)

Neomycin sulfate, a broad-spectrum antibiotic, was first isolated in 1949 and has subsequently been included in topical, oral and parenteral preparations. Its value in the treatment of diarrhoea is widely questioned although it is still contained in a number of widely available antidiarrhoeal preparations. In some countries the officially approved indications for oral preparations are restricted to the preparation of the bowel prior to surgery and the management of hepatic coma.

Contact allergens

Neomycin is an antibiotic complex of the aminoglycosides group, extracted from Streptomyces fradiae. It is composed of neomycin A (neamin) and an isomer neobiosamin, either neomycin B (framycetin or Soframycin?) or neomycin C. Its use has been progressively forbidden in cosmetics and as an additive for animal feed. Occupational contact dermatitis occurs in workers at animal feed mills, in veterinaries, or in health workers. Nonoccupational dermatitis mainly concerns patients with chronic dermatitis, leg ulcers, or chronic otitis. Cross-sensitivity is usual with other aminoglycosides (amikacin, arbekacin, butirosin, dibekacin, gentamicin, isepamicin, kanamycin, paromomycin, ribostamycin, sisomycin, tobramycin), is rare with netilmicin and streptomycin, but nonexistent with spectinomycin.

Clinical Use

In a search for antibiotics less toxic than streptomycin,Waksman and Lechevalier isolated neomycin (Mycifradin,Neobiotic) in 1949 from Streptomyces fradiae. Since then, theimportance of neomycin has increased steadily, and today, itis considered one of the most useful antibiotics for the treatmentof GI infections, dermatological infections, and acutebacterial peritonitis. Also, it is used in abdominal surgery toreduce or avoid complications caused by infections from bacterialflora of the bowel. It has broad-spectrum activityagainst various organisms and shows a low incidence of toxicand hypersensitivity reactions. It is absorbed very slightlyfrom the digestive tract, so its oral use ordinarily does not produce any systemic effect. The development of neomycinresistantstrains of pathogens is rarely reported in those organismsagainst which neomycin is effective.
Neomycin as the sulfate salt is a white to slightly yellow,crystalline powder that is very soluble in water. It is hygroscopicand photosensitive (but stable over a wide pH rangeand to autoclaving). Neomycin sulfate contains the equivalentof 60% of the free base.
Neomycin, as produced by S. fradiae, is a mixture ofclosely related substances. Included in the “neomycin complex”is neamine (originally designated neomycin A) andneomycins B and C. S. fradiae also elaborates another antibiotic,the fradicin, which has some antifungal propertiesbut no antibacterial activity. This substance is not present in“pure” neomycin.

Safety Profile

Poison by intramuscular, intravenous, and subcutaneous routes. Human systemic effects by ingestion: somnolence, hallucinations and distorted perceptions, and anorexia. A human skin irritant. When heated to decomposition it emits very toxic fumes of SOx.

Veterinary Drugs and Treatments

Because neomycin is more nephrotoxic and less effective against several bacterial species than either gentamicin or amikacin, its use is generally limited to topical formulations for skin, eyes, and ears, oral treatment of enteric infections, to reduce microbe numbers in the colon prior to colon surgery, and oral or enema administration to reduce ammonia-producing bacteria in the treatment of hepatic encephalopathy. Doses for parenteral administration are listed below, but should be used only with extreme caution due to the drug’s toxic potential.

Neomycin sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Neomycin sulfate Suppliers

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View Lastest Price from Neomycin sulfate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Neomycin sulfate
1405-10-3
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-10-21 Neomycin Sulphate
1405-10-3
US $100.00 / KG 1KG 99 5tons Shanxi Naipu Import and Export Co.,Ltd
2021-10-20 Neomycin sulfate
1405-10-3
US $95.00-76.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

Neomycin sulfate Spectrum


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