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AC480 (BMS-599626)

AC480 (BMS-599626) structure

CAS No.: 714971-09-2

Chemical Name:: AC480 (BMS-599626)

Synonyms: AC-480;CS-341;CS-1550;NSC133463;BMS-599616;NSC 133463;NSC-133463;BMS 599626 ;AC480 (BMS-599626);BMS599626 Free base

CBNumber:: CB12464670

Molecular Formula:: C27H27FN8O3

Molecular Weight:: 530.55

MDL Number:: MFCD10565678

MOL File:: 714971-09-2.mol

Last updated:2023-06-08 17:06:34

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AC480 (BMS-599626) Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥28.35 mg/mL in DMSO
form	powder to crystal
pka	7.27±0.46(Predicted)
color	White to Light yellow to Light orange
CAS DataBase Reference	714971-09-2
NCI Dictionary of Cancer Terms	BMS-599626
FDA UNII	2252724U5N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2934.99.4400

AC480 (BMS-599626) price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5520	BMS-599626 >98.0%(HPLC)	714971-09-2	10mg	$222	2024-03-01	Buy
TCI Chemical	B5520	BMS-599626 >98.0%(HPLC)	714971-09-2	50mg	$771	2024-03-01	Buy
Cayman Chemical	29657	AC480	714971-09-2	5mg	$120	2024-03-01	Buy
Cayman Chemical	29657	AC480	714971-09-2	25mg	$510	2024-03-01	Buy
Cayman Chemical	29657	AC480	714971-09-2	1mg	$36	2024-03-01	Buy

Product number	Packaging	Price	Buy
B5520	10mg	$222	Buy
B5520	50mg	$771	Buy
29657	5mg	$120	Buy
29657	25mg	$510	Buy
29657	1mg	$36	Buy

AC480 (BMS-599626) Chemical Properties,Uses,Production

Uses

BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively.

Uses

It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhibiting tumors in which receptor coexpression and heterodimerization play a major role in driving tumor growth.

Biological Activity

ac480 (bms-599626) is a potent, selective inhibitor of human epidermal growth factor receptor (her) that inhibits her1 and her2 with ic values of 20 nm and 30 nm, respectively. ac480 has been proved to inhibit her1 in an atp-competitive manner. on the contrary, ac480 has shown to be an atp noncompetitive inhibitor of her2 [1]ac480 inhibited the proliferation of sal2 cells derived from a transgenic mouse tumor, breast tumor and gastric carcinoma cell lines, geo colon tumor cells, non–small-cell lung tumor cells line via her1 and/or her2 signalings [1].ac480 by oral administration has been demonstrated to suppress the growth of sal2 tumor, geo xenograft tumor, kpl-4 and bt474 breast tumors, n87 gastric tumor, a549 and l2987 non–small-cell lung tumors in nude mice [1].

target

HER1

References

[1] wong tw1, lee fy, yu c, luo fr, oppenheimer s, zhang h, smykla ra, mastalerz h, fink be, hunt jt,gavai av, vite gd. preclinical antitumor activity of bms-599626, a pan-her kinase inhibitor that inhibits her1/her2 homodimer and heterodimer signaling. clin cancer res. 2006 oct 15;12(20 pt 1):6186-93.

AC480 (BMS-599626) Preparation Products And Raw materials

Raw materials

Preparation Products

AC480 (BMS-599626) Suppliers

Global( 105)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15745	58
Aceschem Inc.	+1-817863-6948 +1-（817）863-6948	sales@aceschem.com	United States	19639	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hebei Duling International Trade Co. LTD	58
Aceschem Inc.	58
LEAPCHEM CO., LTD.	58

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3(R)-HYDROXYMETHYLMORPHOLINE PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE 5-Amino-1-(3-fluorobenzyl)indazole

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Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester (9CI) AC-480 N-[4-[[1-[(3-Fluorophenyl)Methyl]-1H-indazol-5-yl]aMino]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbaMic Acid (3S)-3-MorpholinylMethyl Ester (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1, AC480 (BMS-599626) (S)-morpholin-3-ylmethyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-ylcarbamate (3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate [(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrrolo BMS-599616 BMS599626 Free base [(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrr (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f] (S)-MORPHOLIN-3-YLMETHYL 4-(1-(3-FLUOROBENZYL)-1H-INDAZOL-5-YLAMINO)-5-METHYLPYRROLO[2,1-F][1,2,4]-TRIAZIN-6-YLCARBAMATE CARBAMIC ACID, [4-[[1-[(3-FLUOROPHENYL)METHYL]-1H-INDAZOL-5-YL]AMINO]-5-METHYLPYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]-, (3S)-3-MORPHOLINYLMETHYL ESTER BMS 599626 CS-341 CS-1550 BMS599626;AC-480; BMS 599626 (AC480) Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester AC480 (BMS-599626) USP/EP/BP NSC 133463 NSC133463 NSC-133463 BMS-599626 BMS599626 AC480 714971-09-2 8173837-23-1 C26H25FN8O3 C27H27FN8O3 Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals