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PeraMpanel

Description Indications Dose titration Interactions Special populations Behavioural and cognitive effects in patients with epilepsy Psychiatric use
PeraMpanel
PeraMpanel
CAS No.
380917-97-5
Chemical Name:
PeraMpanel
Synonyms
E 2007;Perampane;PeraMpanel;ER 155055-90;PeraMpanel-D5;PeraMpanel-13C6;ER 155055-90 Perampanel;2-(2-oxo-1-phenyl-5-pyridin-2- ylpyridin-3-yl)benzonitrile;3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one;3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one
CBNumber:
CB12598797
Molecular Formula:
C23H15N3O
Formula Weight:
349.3847
MOL File:
380917-97-5.mol

PeraMpanel Properties

SAFETY

PeraMpanel price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23003 Perampanel ≥98% 380917-97-5 10mg $45 2018-11-19 Buy
Cayman Chemical 23003 Perampanel ≥98% 380917-97-5 50mg $191 2018-11-19 Buy
Cayman Chemical 23003 Perampanel ≥98% 380917-97-5 100mg $293 2018-11-19 Buy
Cayman Chemical 23003 Perampanel ≥98% 380917-97-5 250mg $675 2018-11-19 Buy

PeraMpanel Chemical Properties,Uses,Production

Description

Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA.

Indications

Epilepsy: Adjunctive treatment of focal seizures with or without secondary generalization and primary generalized tonic- clonic seizures.

Dose titration

Epilepsy— adjunctive therapy: 2 mg nocte for at least 14 days, then increased by 2 mg every 14 or more days; usual maintenance 4– 8 mg nocte (max. 12 mg nocte).

Interactions

With AEDs
  • Some AEDs known as CYP450 3A enzyme inducers (carbamazepine, oxcarbazepine, phenytoin) have been shown to increase perampanel clearance and consequently to decrease plasma concentrations of perampanel. Carbamazepine, a known potent enzyme inducer, reduced perampanel levels by two- thirds in a study performed on healthy subjects
  • In the epilepsy population pharmacokinetic analysis, perampanel was found to decrease the clearance of oxcarbazepine by 26%. Oxcarbazepine is rapidly metabolized by cytosolic reductase enzyme to the active metabolite, monohydroxycarbazepine. The effect of perampanel on monohydroxycarbazepine concentrations is not known.

With other drugs
  • Strong inducers of cytochrome P450, such as rifampicin and St John’s Wort (Hypericum perforatum), are expected to decrease perampanel concentrations.
  • In healthy subjects, the CYP3A4 inhibitor ketoconazole increases perampanel exposure.
  • Perampanel can make certain hormonal contraceptives such as levonorgestrel less effective.
  • Decrease in exposure of midazolam may be caused by perampanel.

With alcohol/food
  • Drinking alcohol while taking perampanel can affect a patients’ alertness and ability to drive or use tools or machines. It can also aggravate irritability, confusion, and depression.
  • There are no specific foods that must be excluded from diet when taking perampanel.

Special populations

Hepatic impairment
  • Increase at intervals of at least 2 weeks, up to a maximum of 8 mg daily, in mild- to- moderate impairment.
  • Avoid in severe impairment.

Renal impairment
Avoid in moderate or severe impairment.

Pregnancy
  • There are limited amount of data available on the use of perampanel in pregnant women and the potential risk for humans is unknown.
  • Perampanel is not recommended in pregnancy and female patients must use a reliable method of contraception to avoid becoming pregnant while being treated with perampanel (this should be continued for 1 month after stopping treatment).
  • As perampanel can make certain hormonal contraceptives such as levonorgestrel less effective, other forms of safe and effective contraception (such as a condom or coil) should be used when taking perampanel (this should be continued for 1 month after stopping treatment).
  • Perampanel has been found to be present in milk in animal studies and it is recommended that breastfeeding should be avoided.

Behavioural and cognitive effects in patients with epilepsy

For this third- generation agent, clinical experience is still limited, and little is known about its positive and negative psychotropic properties, and their implications for the management of behavioural symptoms in patients with epilepsy. There are initial reports of behavioural disturbances (especially depression, anxiety, irritability, and psychosis), which seem to be dose- related and tend to appear within the first weeks of treatment. Reports of cognitive effects (mainly affecting memory) are relatively rare.

Psychiatric use

Perampanel has no indications for the treatment of psychiatric disorders. There is insufficient experience with perampanel to draw any conclusion regarding its psychotropic profile.

Definition

ChEBI: A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.

PeraMpanel Preparation Products And Raw materials

Raw materials

Preparation Products


PeraMpanel Suppliers

Global( 96)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 305 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1531 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20001 58
Shanghai Langxu Biological Technology Co., Ltd. 021-50800795
021-50800795 info@shochem.com China 152 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2930 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Jia Xing Isenchem Co.,Ltd 0573-85280080,18627885956
0573-85285100 isenchem@163.com,QQ:2446116053 China 9796 66
Shanghai Growingchem Co., Ltd. 86-0556-5282330,18621117859
86-0556-5282330 sales@growingchem.com China 64 64

View Lastest Price from PeraMpanel manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 PeraMpanel
US $15.00 / KG 1KG 98% 100KG career henan chemical co
2018-07-23 PeraMpanel
380917-97-5
US $150.00 / KG 1KG 98% 1000KG career henan chemical co

380917-97-5(PeraMpanel)Related Search:


  • PeraMpanel
  • E 2007
  • ER 155055-90
  • PeraMpanel-D5
  • PeraMpanel-13C6
  • 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one
  • 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
  • 2-(2-oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
  • 2-(6'-Oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
  • Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-
  • ER 155055-90 Perampanel
  • Perampane
  • 2-(2-oxo-1-phenyl-5-pyridin-2- ylpyridin-3-yl)benzonitrile
  • Perampane,Perampanel Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)
  • 380917-97-5
  • C1713C6H15N3O
  • API
  • Inhibitors
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