Isradipine
- CAS No.
- 75695-93-1
- Chemical Name:
- Isradipine
- Synonyms
- Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine
- CBNumber:
- CB2268682
- Molecular Formula:
- C19H21N3O5
- Molecular Weight:
- 371.39
- MDL Number:
- MFCD00153820
- MOL File:
- 75695-93-1.mol
- MSDS File:
- SDS
Melting point | 166-1680C |
---|---|
Boiling point | 501.9±60.0 °C(Predicted) |
Density | 1.249±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ~26 mg/mL |
form | solid |
pka | 2.56±0.70(Predicted) |
color | yellow |
Merck | 14,5240 |
BCS Class | 2/4 |
Stability | Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
InChIKey | HMJIYCCIJYRONP-UHFFFAOYSA-N |
CAS DataBase Reference | 75695-93-1(CAS DataBase Reference) |
FDA UNII | YO1UK1S598 |
ATC code | C08CA03 |
NIST Chemistry Reference | Isradipine(75695-93-1) |
Isradipine price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I6658 | Isradipine ≥98% (HPLC), solid | 75695-93-1 | 5mg | $212 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.08507 | Isradipine - CAS 75695-93-1 - Calbiochem A voltage gated calcium channel gating inhibitor of the dihydropyridine class. | 75695-93-1 | 10MG | $142 | 2024-03-01 | Buy |
Sigma-Aldrich | 1354207 | Isradipine United States Pharmacopeia (USP) Reference Standard | 75695-93-1 | 200mg | $375 | 2024-03-01 | Buy |
TCI Chemical | I0876 | Isradipine >98.0%(HPLC) | 75695-93-1 | 25mg | $157 | 2024-03-01 | Buy |
Alfa Aesar | J63920 | Isradipine, 98+% | 75695-93-1 | 10mg | $117.65 | 2024-03-01 | Buy |
Isradipine Chemical Properties,Uses,Production
Description
Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.
Chemical Properties
Yellow Solid
Originator
Sandoz (Switzerland)
Uses
nonsedating H1-antihistamine
Uses
Dihydropyridine calcium channel blocker. Antihypertensive; antianginal
Uses
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Definition
ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.
brand name
Dynacirc (Reliant);Prescal.
General Description
Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.
Biological Activity
Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.
Biochem/physiol Actions
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
storage
Room temperature
References
1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240
Isradipine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8132 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15394 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5987 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9316 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
View Lastest Price from Isradipine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Isradipine
75695-93-1
|
US $0.00 / G | 1G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2021-11-02 | Isradipine
75695-93-1
|
US $158.00 / g | 10g | 99% | 1000kg | Baoji Guokang Healthchem co.,ltd | ||
2021-07-10 | Isradipine
75695-93-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- Isradipine
75695-93-1
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- Isradipine
75695-93-1
- US $158.00 / g
- 99%
- Baoji Guokang Healthchem co.,ltd
- Isradipine
75695-93-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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