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Efficient diuretics Chemical properties Uses production method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Furosemide structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Furosemide Properties

Melting point:
220 °C (dec.) (lit.)
Boiling point:
582.1±60.0 °C(Predicted)
refractive index 
1.6580 (estimate)
Flash point:
11 °C
storage temp. 
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
pKa 3.8 (Uncertain)
Water Solubility 
Soluble in acetone, DMF or methanol. Slightly soluble in water
Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents.
CAS DataBase Reference
54-31-9(CAS DataBase Reference)
NCI Drug Dictionary
ATC code
3 (Vol. 50) 1990
EPA Substance Registry System
Furosemide (54-31-9)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H303-H225-H301+H311+H331-H370-H360
Precautionary statements  P202-P405-P501a-P210-P260-P280-P301+P310-P311-P201-P308+P313
Hazard Codes  T,F,Xi
Risk Statements  61-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  7-16-36/37-45-53-36/37/39-22-36-26
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS  CB2625000
HS Code  2935904000
Toxicity LD50 orally in female, male rats: 2600, 2820 mg/kg (Goldenthal)

Furosemide price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F-005 Furosemide solution 1.0mg/mL in methanol, ampule of 1mL, certified reference material 54-31-9 005-1ml $55 2020-08-18 Buy
Sigma-Aldrich F-005 Furosemide solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 54-31-9 1 mL $56.8 2021-03-22 Buy
Sigma-Aldrich F0700000 Furosemide European Pharmacopoeia (EP) Reference Standard 54-31-9 $190 2021-03-22 Buy
Sigma-Aldrich Y0001493 Furosemide for peak identification European Pharmacopoeia (EP) Reference Standard 54-31-9 $190 2021-03-22 Buy
Sigma-Aldrich 1287008 Furosemide United States Pharmacopeia (USP) Reference Standard 54-31-9 200mg $366 2021-03-22 Buy

Furosemide Chemical Properties,Uses,Production

Efficient diuretics

Furosemide, is a class of efficient sulfonamide diuretics acting on the medullary loop of the ascending branch of the medulla,it has a strong and short-term diuretic effect,which can increase the excretion of water, sodium, chloride, potassium, calcium, magnesium, phosphate and so on. It Mainly inhibits Na + and Cl-reabsorption in medullary and cortex of the medullary loop ascending branch crude segment , it can promote the excretion of sodium, chloride and potassium and affect the formation of renal medullary high osmotic pressure,it can interfer the process of concentration and dilution of urine, and it can increase urine output. This product can inhibit the activity of prostaglandin decomposition enzyme ,make the content of prostaglandin E2 increase,it has effect on expansion of blood vessels, it also plays a role in the proximal tubule, glomerular filtration,it can increase renal blood flow,and adjust renal blood flow distribution,and reduce blood flow so that the cortex surface blood flow increases,it promotes diuresis, its effect is fast and strong, it is used for other diuretics invalid cases. Clinically it is used for the treatment of cardiac edema, renal edema, cirrhosis ascitic fluid, peripheral edema caused by dysfunction or vascular disorders , and it may contribute to an upper urinary tract stones excretion. Administration intravenously can treat brain edema, it also can accelerate the excretion of toxic substances in cerebral edema in poisoning . Note that when the diuretic furosemide is used, since the excretion of urine Cl-, Na +, K +, H + is increasing, while the excretion of HCO3-is not increasing, long-term repeated drug use or large quantities of drugs can cause low salt syndrome, low chlorine and low potassium alkalosis.
In recent years, researchers find that inhalation of furosemide can have a significant effect on asthma, it is like cromolyn sodium, which through inhibition of allergic mediator release, it can inhibit the release of the neurotransmitter acetylcholine and substance P, which may be related to inhibiting chloride ions into the cell membranes of respiratory tract. Clinically,it is used in exercise-induced asthma, immediate and delayed type antigen-induced asthma.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical properties

white or white alike crystalline powder. 206 ℃ melting point. Dissolved in acetone, methanol, dimethyl formamide, slightly soluble in ethanol, insoluble in water. Odorless, almost tasteless.


The diuretic effect of this product is a strong and short,it is a potent diuretic for the treatment of edema caused by heart, liver, kidney and other diseases, in particular, the base cases which other diuretics are invalid to;it can be used to treat acute pulmonary edema, brain edema , acute renal failure and high blood pressure and other diseases; in combination with fluid infusion, the product can promote poison excretion. Rat oral LD50 is 2600-2820mg/kg.

production method

2,4-dichlorobenzoic acid (see 12740) by sulfochlorination,ammoniation, acidification ,dichloro-5-sulfamoyl-benzoic acid is obtained. Then after condensation with the chaff amine , furosemide is produced.


Toxic substances

Toxicity grading

Middle toxic

Acute toxicity

Oral-rat LD50: 2600 mg/kg; Oral-Mouse LD50: 2200 mg/kg.

Flammability and hazard characteristics

Combustible; fire decomposition produces toxic nitrogen oxides; sulfur oxides and chlorides smoke.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Water, carbon dioxide, dry powder,sandy soil.

Chemical Properties

white to light yellow crystal powde


Lasix,Hoechst,W. Germany,1964


diuretic, antihypertensive


Furosemide inhibits ion co-transport in the kidney. Furosemide is used as a diuretic.


This compound belongs to the aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.


An inhibitor of NKCC and a GABAA receptor antagonist.


A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration and anti-hypertensive agent.

Manufacturing Process

10.8 grams of 3-sulfamyl-4,6-dichlorobenzoic acid (0.04 mol) and 11.7 grams of furfurylamine (0.12 mol) are heated in 30 cc of diethyleneglycoldimethylether for 6 hours under reflux. When pouring the reaction mixture into 300 cc of 1 N hydrochloric acid, the reaction product is immediately separated off in the form of crystals. The light-yellow crude product is purified by dissolving it in 100 cc of warm 1 N sodium bicarbonate solution, precipitation by means of hydrochloric acid and subsequent recrystallization from ethanol/water, with addition of charcoal. Colorless prisms are obtained which decompose at 206°C while adopting a brown coloration, and with evolution of gas.

brand name

Lasix (Sanofi Aventis).

Therapeutic Function


General Description

Odorless white to slightly yellow crystalline powder. A diuretic drug. Almost tasteless.

Air & Water Reactions

Light sensitive. Air sensitive. Slightly soluble in water.

Reactivity Profile

Furosemide may undergo hydrolysis at sufficiently low pH. The pH of aqueous solutions should be maintained in the basic range to prevent hydrolysis. Alcohol has been shown to improve the stability of Furosemide. Incompatible with strong oxidizing agents .


Poison; moderately toxic; teratogen; questionable carcinogen; mutagen.

Fire Hazard

Flash point data for Furosemide are not available; however, Furosemide is probably combustible.

Biological Activity

Loop diuretic that inhibits the Na + /2Cl - /K + (NKCC) cotransporter. Also acts as a non-competitive antagonist at GABA A receptors with ~ 100-fold greater selectivity for α 6-containing receptors than α 1-containing receptors.

Mechanism of action

Furosemide is a highly effective and quick-acting diuretic whose action, like all of the examined loop diuretics, is associated with blocking reabsorption of ions in the ascending bend of Henle’s loop. It is used for edema syndrome of various origins, edema of the lungs and brain, chronic renal insufficiency, some forms of hypertonic crises, and poisoning by barbiturates and other compounds excreted mainly with urine.

Clinical Use

Furosemide has a saluretic effect 8- to 10-fold that of the thiazide diuretics; however, it has a shorter duration of action (~6–8 hours). Furosemide causes a marked excretion of sodium, chloride, potassium, calcium, magnesium, and bicarbonate ions, with as much as 25% of the filtered load of sodium excreted in response to initial treatment. It is effective for the treatment of edemas connected with cardiac, hepatic, and renal sites. Because it lowers the blood pressure similar to the thiazide derivatives, one of its uses is in the treatment of hypertension.

Side effects

Clinical toxicity of furosemide and other loop diuretics primarily involves abnormalities of fluid and electrolyte balance. As with the thiazide diuretics, hypokalemia is an important adverse effect that can be prevented or treated with potassium supplements or coadministration of potassium-sparing diuretics. Increased calcium ion excretion can be a problem for postmenopausal osteopenic women, and furosemide generally should not be used in these individuals. Hyperuricemia, glucose intolerance, increased serum lipid levels, ototoxicity, and gastrointestinal side effects might be observed as well. Hypersensitivity reactions also are possible with furosemide (a sulfonamide-based drug), and cross-reactivity with other sulfonamide containing drugs is possible.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: change in the sensitivity of the ear to sound, tinnitus, unspecified effects on the heart, constriction of the arteries, a decrease in urine volume, interstitial nephritis, metabolic alkalosis, pulse rate decrease, fall in blood pressure. Ingestion can damage the liver. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.

Chemical Synthesis

Furosemide, 4-chloro-N-furfuryl-5-sulfamoylanthranylic acid (21.4.11), is synthesized in a relatively simple manner from 2,4-dichlorobenzoic acid, which is converted into 5-aminosulfonyl-4,6-dichlorobenzoic acid (21.4.10) during subsequent reaction with chlorosulfonic acid and ammonia. Reacting this with furfurylamine gives furosemide (21.4.11) .

Veterinary Drugs and Treatments

Furosemide is used for its diuretic activity in all species. It is used in small animals for the treatment of congestive cardiomyopathy, pulmonary edema, hypercalcuric nephropathy, uremia, as adjunctive therapy in hyperkalemia and, occasionally, as an antihypertensive agent. In cattle, it is approved for use for the treatment of post-parturient udder edema. It has been used to help prevent or reduce epistaxis (exercise-induced pulmonary hemorrhage; EIPH) in racehorses.

Furosemide Preparation Products And Raw materials

Raw materials

Preparation Products

Furosemide Suppliers

Global( 377)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Rixing Chemical CO.,LTD
- CHINA 229 55
Guangzhou Dihao Medical Technology Co., Ltd
+8618602015453 CHINA 41 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37127788 CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8909 55
Guangzhou PI PI Biotech Inc
020-81716319; China 3245 55
Hubei XinRunde Chemical Co., Ltd.
02783214688 CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
+8619933070948 China 479 58
+86 18953170293
+86 0531-67809011 CHINA 2941 58

View Lastest Price from Furosemide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Furosemide
2021-12-02 Furosemide
US $0.00 / Kg/Drum 1KG 99.9% 100000kg per month Wuhan Mulei New Material Technology Co. Ltd
2021-11-30 Furosemide
US $3125.00 / Kg/Drum 25KG 99% 1T Baoji Guokang Bio-Technology Co., Ltd.

Furosemide Spectrum

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