ChemicalBook >> CAS DataBase List >>Lactonitrile


Chemical Name:
nsc7764;Laktonitril;lactonitrite;LACTONITRILE;DL-LACTONITRILE;Acetocyanohydrin;acetaldehydcyanhydrin;ethylidene cyanhydrin;2-Hydroxypropannitril;β-hydroxypropionitrile
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Modify Date:2022-08-15 17:41:25

Lactonitrile Properties

Melting point -40.15°C
Boiling point 90 °C17 mm Hg(lit.)
Density 0.991 g/mL at 20 °C(lit.)
refractive index n20/D 1.404
Flash point 77 °C
storage temp. Refrigerator, under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Oil
pka 11.38±0.20(Predicted)
color Colourless
BRN 605366
CAS DataBase Reference 78-97-7(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference Propanenitrile, 2-hydroxy-(78-97-7)
EPA Substance Registry System Lactonitrile (78-97-7)


Risk and Safety Statements

Signal word  Danger
Hazard statements  H290-H300+H310+H330-H351-H360FD-H373-H410
Precautionary statements  P202-P234-P273-P280-P302+P352+P310-P304+P340+P310
Hazard Codes  T+,T
Risk Statements  23/25-27-25-20
Safety Statements  13-36/37/39-45-23-36/37-28
RIDADR  UN 3276 6.1/PG 1
WGK Germany  3
RTECS  OD8225000
HazardClass  6.1(a)
PackingGroup  II
NFPA 704
4 0

Lactonitrile price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 69830 DL-Lactonitrile ≥97.0% (T) 78-97-7 25ml $70 2022-05-15 Buy
Sigma-Aldrich 69830 DL-Lactonitrile ≥97.0% (T) 78-97-7 100ml $233 2022-05-15 Buy
Product number Packaging Price Buy
69830 25ml $70 Buy
69830 100ml $233 Buy

Lactonitrile Chemical Properties,Uses,Production

Chemical Properties

Lactonitrile, is soluble in water and alcohol, but insoluble in diethyl ether and carbon disulfide. Lactonitrile is used chiefly to manufacture lactic acid and its derivatives, primarily ethyl lactate.


2-Hydroxypropanenitrile is a useful compound for efficient lactamide synthesis by fed batch method using nitrile hydratase of Rhodococcus pyridinivorans NIT-36.


It is used primarily as a solvent, and as an intermediate in production of ethyl acetate and lactic acid.

Production Methods

Lactonitrile is manufactured from equimolar amounts of acetaldehyde and hydrogen cyanide containing 1.5% of 20% NaOH at ?10–20 °C. The product is stabilized with sulfuric acid. Sulfuric acid hydrolyzes the nitrile to give a mixture of lactic acid and ammonium bisulfate. This mixture can be purified by adding methanol to form methyl lactate which is separated from the ammonium bisulfate. The methyl lactate is distilled, then hydrolyzed back to the aqueous acid. Removal of most of the water yields 90% lactic acid.

Production Methods

Lactonitrile is derived from acetaldehyde and hydrocyanic acid.

General Description

Straw colored liquid. Used as a solvent /intermediate in production of ethyl lactate and lactic acid.

Air & Water Reactions

Water soluble.

Reactivity Profile

Lactonitrile is incompatible with strong acids, strong bases and strong reducing agents. Lactonitrile is also incompatible with strong oxidizers. In the presence of alkali, Lactonitrile evolves toxic compounds. .

Health Hazard

Extremely toxic by oral, skin, or eye contact.

Fire Hazard

Cyanide fumes released when heated to decomposition. Avoid alkali, oxidizing material.

Lactonitrile Preparation Products And Raw materials

propanenitrile,2-hydroxy- Propionitrile, 2-hydroxy- DL-LACTONITRILE, STAB. acetaldehydcyanhydrin 2-hydroxypropylnitrile ethylidene cyanhydrin lactonitrite β-hydroxypropionitrile 2-Hydroxypropionitrile, Acetaldehyde cyanohydrin ETHYLIDENE CYANOHYDRIN DL-LACTONITRILE LACTONITRILE Acetaldehyde cyanhydrin 2-hydroxy-propanenitril 2-Hydroxypropannitril 2-hydroxy-propionitril Acetocyanohydrin alpha-Hydroxypropionitrile Laktonitril nsc7764 2-HYDROXYPROPANENITRILE 2-HYDROXYPROPIONITRILE 2-HYDROXYETHYL CYANIDE ACETALDEHYDCYANOHYDRIN ACETALDEHYDE CYANOHYDRIN 78-97-7 CH3CHOHCN C2H4OHCN Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks C1 to C5 Building Blocks Building Blocks C1 to C5 Chemical Synthesis Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks