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Imiquimod

Drug for treatment of Genital warts Clinical Study Mechanism of action Usage and Dosage Side effects Precautions Uses
Imiquimod
Imiquimod structure
CAS No.
99011-02-6
Chemical Name:
Imiquimod
Synonyms
R-837;ALDARA;S-26308;imiqimod;IMIQUIMOD;Imiquimod-d9;Imiquimod,98%;Imiquimod (200 mg);IMiquiMod (Aldara);IMiquiMod(Aldara,R 837)
CBNumber:
CB2664655
Molecular Formula:
C14H16N4
Formula Weight:
240.3
MOL File:
99011-02-6.mol

Imiquimod Properties

Melting point:
292-294°C
storage temp. 
Store at +4°C
solubility 
DMSO: soluble
form 
White solid
Water Solubility 
Soluble in dimethyl sulfoxide and dimethyl formamide. Slightly soluble in water. Insoluble in ethanol.
λmax
245nm(H2O/MeOH)(lit.)
Merck 
14,4922
Stability:
Incompatible with strong oxidizing agents.
InChIKey
DOUYETYNHWVLEO-UHFFFAOYSA-N
CAS DataBase Reference
99011-02-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300-H315-H319-H335-H301
Precautionary statements  P280a-P301+P310a-P405-P501a-P261-P264-P301+P310-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  26-45-36/37/39-27
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  NJ5903450
HazardClass  6.1
PackingGroup  III
HS Code  29339900

Imiquimod price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 401020 Imiquimod 99011-02-6 250mg $174 2018-11-20 Buy
Sigma-Aldrich 1338313 Imiquimod United States Pharmacopeia (USP) Reference Standard 99011-02-6 200mg $348 2018-11-13 Buy
TCI Chemical I0747 Imiquimod >98.0%(HPLC)(T) 99011-02-6 100mg $57 2018-11-22 Buy
TCI Chemical I0747 Imiquimod >98.0%(HPLC)(T) 99011-02-6 1g $297 2018-11-22 Buy
Alfa Aesar J63990 Imiquimod, 99% 99011-02-6 1g $292 2018-11-13 Buy

Imiquimod Chemical Properties,Uses,Production

Drug for treatment of Genital warts

Imiquimod is a kind of imidozoquinoline amine-class interleukin agonist developed by the 3M Pharmaceuticals Company (US), belonging to the drug for the treatment of genital warts. Upon being applied to the mice skin, it can induce the cytokinesis and produce α-interferon, tumor necrosis factor and many kinds of interleukins. Clinically it can be used as the immunomodulators in the treatment of adult genital and perianal warts with convenient application, well tolerance and unique mechanism of action which makes it be the first-choice drug for treatment of genital warts. In addition, there are reports that imiquimod can be used for treating viral skin diseases including common warts, flat warts, molluscum and herpes simplex virus. It can also be effective in treating basal cell carcinoma, Bowen's disease, Bowen papulosis, actinic keratosis, and skin tumors such as cutaneous T-cell tumor and Kaposi's sarcoma. It may also be effective in treating vitiligo and alopecia areata.
Genital wart is the infective diseases of the human herpes virus (HPV) infection and is a major public health threat. Currently, the infection of the genital wart in the United States is the most common viral infective sexually transmitted diseases and one of the most common sexually transmitted diseases. The infections mostly occur in sexually active people, especially for people of 20 to 24 year-olds and women in pregnancy, and prone to happen at the warm and most mucosal sites of body. Application of immunosuppressive agents or infection with the patients of human immunodeficiency virus is prone to cause severe clinical signs of infection.

Clinical Study

In an unpublished report, 209 cases of patients of genital or perianal warts have been subjected to a double-blind trial with both this product and vehicles being used for three times per week for continuous 16 weeks. The results have shown that, 33 cases in 46 cases of women (72%), 21 cases in 63 cases of male(33%) get cured with the total wart cure rate being 50%, while only 11% (20% of women and 5% male) in the vehicles group get cured. There have been patients who get cured within treatment of only 4 weeks. The average healing time is twelve weeks for men and eight weeks for women. In the following 12 weeks, there were 39 cases in 54 cases that got no recurrence any more.

Mechanism of action

Imiquimod itself has no direct effect on the virus itself, but instead through stimulating the body for producing cytokines and stimulating immune response to eliminate the wart tissue and reduce the viral erosion.
Both in vivo and in vitro studies have suggested that imiquimod can stimulate the mice, rats, rabbits, guinea pigs, monkeys and humans for producing cytokine. Racial cross cell culture tests have shown that the main responsive cells are monocytes/macrophages; cultured human peripheral mononuclear cells (PBMC) which can produce several subtypes of IFN-α, TNF-α, IL-1,6,6 , 10,12, MIP-1 and MCP-1; the human single cell THP-1 will respond only when being pre-subject to γ-IFN treatment and produce TNF-α, IL-1,6,8, but do not produce IFN-α; performing the same treatment on the fresh mice PBMC can generate the same cytokine as human PBMC; senescence macrophages and alveolar macrophages produce the same cytokines, the mouse RAW264.7 and J774 macrophages family can produce TNF-α and IL-6 without producing IFN-α. Through intracellular test, we can confirm that imiquimod can induce IFN-α and TNF-α.
Through putting the human fibroblasts and keratinocytes with the mixture of imiquimod or poly-inosine: poly-cytidine for incubation of 24 hours, people has found that the mRNA of keratinocytes IL-6 and IL-8 (no TNF-α) had increased but only appropriate amount of IL-8 protein had been detected. At high concentration, the secretion of the fibroblasts IL-8 is similar with keratinocytes; The immune response of caused by the imiquimod-induced secretion of cytokines is similar with the DTH response; imiquimod can activate the anti-tumor activity and DTH response of the HPV E7 gene transfected tumor bearing mice; human and animal experiments have shown that imiquimod could increase the 2'5'-oligo-adenylate synthase which can induce the interferon for inducing the antiviral effect; interferons and other cytokines can activate NK cells to kill tumor cells and the virus-infected cells; both in vivo and in vitro tests have showed that the imiquimod can increase activity of NK and stimulate the proliferation and activation of mouse spleen B cells which is the direct effect rather than being mediated by cytokine; imiquimod does not directly enhance T-lymphocyte activity; but in vitro mitogenic response can stimulate T-cells for enhancing the production and proliferation of IL-2. In vivo experiments have demonstrated that it can enhance T cell activity; imiquimod can increase the generation of IL-2 of the HSV infected guinea pig, T cell proliferation and T cell activity to enhance the cell-mediated immune response.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Usage and Dosage

It can be used for the treatment of adult external genital and perianal genital warts at 3 times per week. Just before sleep, first apply the product evenly in a thin layer on the surface of the wart and gently massage until the product is completely absorbed. The position of the medication should not be packeted and should be maintained for 6 to 10 hours, and then wash with a neutral soap and clean water for clearing the drugs in the administration site. Wash your hands before and after treatment. 250 mg of cream can be applied to 20cm2 of wart. Avoid excessive application of the drug. Patients should continue the treatment until the wart is completely cleared. Wart can be cleared within 2-4 week at the fastest speed and can be generally cleared within 8 to 12 weeks. The medication should be not more than 16 weeks. After the treatment, patients with mild erythema locally who does not have to be discontinued for drug; if the patients feel general malaise or get local skin reactions (edema, erosion, pain, etc.), the drug should be discontinued. Only when the reaction is alleviated can they continue the medication.

Side effects

1, the majority of patients get no adverse reactions during the treatment. After several times of treatment, the clinical adverse reactions are mostly mild, moderate local skin inflammation. For example, there may be local skin erythema, edema, erosion, ulcers, desquamation, burning, pain, itching and so on.
2, there is occasional transient fever and these symptoms can quickly recover after stopping the drugs. If the reactions are mild, you can continue for the treatment. However, the patients should discontinue the drug on time and should be subject to medical treatment if severe reactions happen.
3, According to the reports of foreign information, possible adverse reactions associated with imiquimod cream include discomfort in the medication site, wart site reactions (burning, pigmentation, inflammation, itching, pain, rash, sensitivity, ulcers, tingling and tenderness).Distal site reactions (bleeding, burning, itching, pain and tenderness), fatigue, fever, flu-like symptoms, headache, diarrhea, myalgia.

Precautions

1. No packets; wash away the drug after 6 to 10 hours of the drug administration. The patients should avoid using this product in partial breakage place. There have been reports of using drugs or laser for treatment of genital warts that lead to the emergence of damaged parts. In that case, we should continue the drugs until the wound get healed.
2. It should not be applied to the treatment of genital warts located at the eyes, mouth, nose, urethra, vagina, cervix and anal mucous membranes.
3. You should avoid sex during the treatment. For patients using condom, the patients should first clean the topical imiquimod because imiquimod can make condom be fragile.
4. For male patients with foreskin, during the treatment, the patients should reveal the foreskin every day and clean the application site. If the foreskin mucosa surface gets erosion, ulceration, edema and difficulty for turning up foreskin, you should immediately stop the treatment.
5. There have been no reports regarding the drug contraindications in pregnant and lactating women, but the patients should use with caution.

Uses

It can be used for anti-genital warts and as immunomodulators

Description

Aldara was launched in the US for the topical treatment of genital warts caused by human papillomavirus (HPV). It can be prepared in a six step approach beginning with the nucleophilic substitution of 4-chloro-3-nitroquinolone with isobutylamine or via a thermal electrocyclic ring closure of 1 - and 2-azahexatriene systems. Aldara has antiviral and antitumor properties, with the former activity arising from the induction of cytokines, in particular, INF-α. Aldara also induces TNF-γ, IL-1α, IL-1β, IL-1ra, IL-6, IL-8, IL-10, GM-CSF, G-CSF and MID-la formation 1-4 hr after stimuli. The exact cells responsible for the response have not been determined, however, it is not activating T lymphocytes, NK cells, B lymphocytes, or dendritic stem cells but monocytes (CD14+, CD36+, HLA-DR+, HLA-DQ±, CD19-, CD16- and CD23-) are partly responsible. The speculation is that Aldara may interact with a kinase modulating the transduction pathway leading to cytokine genes. There is no direct antiviral activity (induction of IFN does not follow true dose response) and it is not mutagenic. The hydroxylated metabolite also induces IFN-α.

Chemical Properties

White to off white crystalline powder

Originator

3M Pharmaceuticals (US)

Uses

immunomodulator

Uses

raw material for Latamoxef, Cefminox, Ceftizoxime, Cefoxitin, Cefmetazole

Uses

An immune response modifier. It stimulates the production of interferon-a

Indications

Imiquimod (Aldara) is a topical immune response modifier approved for the treatment of anogenital warts (condylomata acuminata). The exact mechanism of action is unknown; it has no direct antiviral activity in vitro. It is thought to work in vivo by inducing the production of tumor necrosis factor (TNF α ), interferons (IFN)α and γ , and other cytokines with antiviral activity. It may also be useful for treatment of other types of warts, molluscum contagiosum, and certain forms of skin cancer. Local irritant reactions related to the frequency of application are common.

brand name

Aldara (3M Pharmaceuticals).

Pharmaceutical Applications

An imidazoquinoline used for the treatment of genital and perianal warts. While the mechanism of action is not precisely known, it is thought to induce interferon. It has no direct antiviral activity. The 5% cream applied three times a week for up to 16 weeks resulted in total wart clearance in 50% of patients, with a better response in women than in men. Local reactions are common and include erythema, erosion, excoriation and edema.

Biological Activity

Immunomodulator that displays antiviral and antitumor activity. Acts as a Toll-like receptor 7 (TLR-7) agonist; stimulates proinflammatory cytokine production and activates NF- κ B.

Veterinary Drugs and Treatments

An immune response modifier, imiquimod may be useful in the treatment of a variety of topical conditions in animals. It is labeled for use on humans as a treatment for genital or perianal warts, superficial basal cell carcinomas and actinic keratoses of the face and scalp. In dogs and cats, imiquimod potentially may be of benefit in treating feline herpes virus dermatitis, actinic keratosis, squamous cell carcinoma and Bowen’s disease, papillomas virus lesions, and localized solar dermatitis or solar carcinoma in situ. In horses, imiquimod has been anecdotally used with success in treating sarcoids.
Imiquimod stimulates the patient’s own immune system to release a variety of cytokines including interferon-alpha and interleukin- 12. Imiquimod itself does not have in vitro activity against wart viruses, but stimulates monocytes and macrophages to release cytokines that induce a regression in viral protein production.

Imiquimod Preparation Products And Raw materials

Raw materials

Preparation Products


Imiquimod Suppliers

Global( 251)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

View Lastest Price from Imiquimod manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-25 Imiquimod
99011-02-6
US $2.00 / kg 1kg 99% 100kg career henan chemical co

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