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Potassium Citrate

Potassium citrate Prevention of urinary calculi drug Chemical properties Uses Production methods Reference
Potassium Citrate
Potassium Citrate structure
CAS No.
866-84-2
Chemical Name:
Potassium Citrate
Synonyms
kajos;seltz-k;porekal;kaliksir;SODIUM POTASSIUM;POTASSIUM CITRATE;Tripotassium citrate;Tripotassium citrate;sdTripotassium Citrate;potassiumcitrateanhydrous
CBNumber:
CB7134348
Molecular Formula:
C6H5K3O7
Formula Weight:
306.39
MOL File:
866-84-2.mol

Potassium Citrate Properties

Melting point:
decomposes at 230℃ [KIR78]
Density 
1.187
solubility 
H2O: 1 M at 20 °C, clear, colorless
PH
8.0-9.5 (25℃, 1M in H2O)
Water Solubility 
60.91 g/100g saturated solution in water (25°C) [MER06]
λmax
λ: 260 nm Amax: 0.045
λ: 280 nm Amax: 0.025
Indirect Additives used in Food Contact Substances
TRIPOTASSIUM CITRATE
FDA 21 CFR
184.1625; 582.1625; 582.6625; 310.545
CAS DataBase Reference
866-84-2(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
EE90ONI6FF
EPA Substance Registry System
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt (866-84-2)
SAFETY
  • Risk and Safety Statements
WGK Germany  1

Potassium Citrate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 89306 Potassium citrate tribasic solution BioUltra, 1M in H 866-84-2 100ml-f $50.2 2019-12-02 Buy
Sigma-Aldrich 89306 Potassium citrate tribasic solution BioUltra, 1M in H 866-84-2 500ml-f $201 2019-12-02 Buy

Potassium Citrate Chemical Properties,Uses,Production

Potassium citrate

The applications of potassium citrate (or tripotassium citrate) mainly derive from its alkaline properties. It is used to treat kidney stones composed of uric acid and cysteine, as well as other renal failures caused by excess acidity, including in veterinary applications. As an additive to soft drinks and other edibles, it also functions as an acid buffer, less bitter than other potassium salts, and with less sodium than trisodium citrate.
An additional use of potassium citrate is to supplement potassium in patients with hypokalemia, preventing and treating gout and arrhythmia.

Prevention of urinary calculi drug

Potassium citrate is the drug which is most commonly used to prevent calculus. It was found that in the urine pH value and citric acid value and have a very close relationship with the formation urinary tract calculus. In an acidic urine (pH <5.5), the uric acid solubility is very low, so it is likely to cause uric acid calculus; while in alkaline urine (pH> 7), it is easy to form calcium or magnesium phosphate calculus. 63% of urinary calculus patients are below normal urine citrate, and potassium citrate can provide a lot of citric acid to enhance the urine pH value. So for uric acid calculus, It has a very significant therapeutic effect to low calcium citrate calculus disease and tubular poisoning calcium calculus disease. But It will raise the concentration of potassium and lower the concentration of ammonium ion in urinary, which is because not only complements the citric acid, but also supplements of potassium. Since potassium metabolism is very quickly in the body, there is no change in blood potassium concentration. It has little effect on the body. The daily amount of total urine, oxalate, phosphate, sodium, magnesium, sulfate and uric acid and other aspects test from patients with uric acid calculus, it is found that it is not affected by taking potassium citrate.

Chemical properties

Colorless crystals or white crystalline powder, odorless, cool and salty, slight deliquescence, soluble in water and glycerin, insoluble in ethanol. Tests show that the product had no significant harm to the human body, ADI doesn’t need special provision (FAO/WHO, 1994).

Uses

As a preservative, stabilizing and pH buffering agents and others. China provides for various types of food, according to production needs to use appropriately.
Used in the food, pharmaceutical and other industries, as buffering agents, chelating agents, flavoring agents, stabilizers, antioxidants, emulsifying salts.

Production methods

Citric acid and potassium hydroxide or potassium bicarbonate derived products.
C6H8O7 + 3KHCO3 → CaH5K3O7 · H2O + 3CO2 ↑ + 2H2O

Reference

https://en.wikipedia.org/wiki/Potassium_citrate
https://kidneystones.uchicago.edu/how-citrate-gets-into-the-urine/
https://www.drugbank.ca/drugs/DB09125
http://www.urocit-k.com/
http://www.jungbunzlauer.com/en/products/special-salts/tripotassium-citrate.html
https://www.quora.com/Why-is-potassium-citrate-buffer-is-an-acid-buffer

Description

Potassium citrate is a potassium salt of citric acid with the molecular formula C6H5K3O7. It is a white, slightly hygroscopic crystalline powder. It is odorless with a saline taste.
As a food additive, potassium citrate is used to regulate acidity and is known as E number E332. Medicinally, it may be used to control kidney stones derived from either uric acid or cystine.

Chemical Properties

Colorless or white crystals or powder; cooling, saline taste; odorless; deliquescent. Soluble in water and glycerol; almost insoluble in alcohol.

Uses

potassium citrate is it acts as a buffer, maintaining product pH constant, a pH adjuster and a product stabilizer. This is a potassium salt.

Uses

For use as an electrolyte replenisher and in the treatment of hypokalemia.

Uses

Potassium citrate is rapidly absorbed when given by mouth and is excreted in the urine. Since it is an alkaline salt it is effective in reducing the pain and frequency of urination when these are caused by highly acidic urine . It is used for this purpose in dogs and cats, but is chiefly employed as a non-irritating diuretic.
Potassium citrate is an effective way to treat/manage gout and arrhythmia, if the patient is hypokalemic.
It is widely used to treat urinary calculi (kidney stones) and is often used by patients with cystinuria .

Production Methods

Potassium citrate is produced by adding potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases, filtering the solution and evaporating to granulation.

Definition

ChEBI: The anhydrous form of the tripotassium salt of citric acid.

Industrial uses

Potassium citrate is used in the United Kingdom as an over-the-counter drug for the relief from discomfort experienced in mild urinary-tract infections by increasing the urinary pH. It should be not given to men if they experience pain in the kidney area (risk of kidney stones) or if blood or pus is present in the urine. Also, patients with raised blood pressure or diabetes should avoid taking potassium citrate without consultation with their general practitioner (GP). Caution is generally advised to patients with renal impairment, cardiac problems and the elderly [3a].

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of K2O.

Precautions

Potassium citrate is usually administered by mouth in dilute aqueous solution. This is because of its somewhat caustic effect on the stomach lining, and the potential for other mild health hazards.
In states where non-prescription potassium citrate is legal, the maximum allowable over-the-counter (OTC) dose for elemental potassium is regulated by the FDA to be no more than 100 mg (approximately 3 % of the daily allowance ) . Pure potassium citrate contains 38.28 % potassium.

Potassium Citrate Preparation Products And Raw materials

Raw materials

Preparation Products


Potassium Citrate Suppliers

Global( 236)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Kolod Food Ingredients Co.,Ltd.
+86-518-85110578 18805133257
+86-518-85110578 sales3257@jskolod.com CHINA 100 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 301 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10157 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2581 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1277 58

View Lastest Price from Potassium Citrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-06-17 Tripotassium citrate
866-84-2
US $20.00 / KG 1T 98% 10T Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
2019-07-05 Pharmaceutical Intermediates grade potassium citrate anhydrous
866-84-2
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2020-05-11 Potassium Citrate
866-84-2
US $0.00-0.00 / KG 1KG 99.0% 100 MT Shaanxi Dideu Medichem Co. Ltd

Potassium Citrate Spectrum


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