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Orphenadrine citrate

Orphenadrine citrate
Orphenadrine citrate structure
Chemical Name:
Orphenadrine citrate
X-Ota;X-Otag;Flexon;Banflex;Benhexal;Flexoject;Einecs 225-137-5;Orphenadrine citrate;ORPHENADRINECITRATE,USP;ORPHENADRINE CITRATE SALT
Molecular Formula:
Formula Weight:
MOL File:

Orphenadrine citrate Properties

Melting point:
storage temp. 
Sparingly soluble in water, slightly soluble in ethanol (96 per cent).
CAS DataBase Reference
4682-36-4(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-40-20/21/22
Safety Statements  22-36-62-38-36/37/39-28-26-24/25
RIDADR  3249
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.

Orphenadrine citrate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O4630 Orphenadrine citrate salt analytical standard 4682-36-4 5g $54.6 2018-11-20 Buy
Sigma-Aldrich 1479009 Orphenadrine citrate salt United States Pharmacopeia (USP) Reference Standard 4682-36-4 200mg $352.8 2018-11-20 Buy
Sigma-Aldrich PHR1777 Orphenadrine citrate Pharmaceutical Secondary Standard; Certified Reference Material 4682-36-4 1g $113 2018-11-20 Buy
Sigma-Aldrich Y0000101 Orphenadrine citrate European Pharmacopoeia (EP) Reference Standard 4682-36-4 y0000101 $187 2018-11-23 Buy

Orphenadrine citrate Chemical Properties,Uses,Production

Chemical Properties

White Solid


skeletal muscle relaxant, antihistaminic agent


A histaminergic compound


Muscle relaxant (skeletal); antihistaminic


ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.

brand name

Norflex (3M Pharmaceuticals).

General Description

Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.

Clinical Use

Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.

Orphenadrine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

Orphenadrine citrate Suppliers

Global( 97)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32452 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2734 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1787 55
career henan chemical co
+86-371-86658258 CHINA 25796 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23959 58
Guangdong Petroleum and Chemical Research Institute 020-82577337
020-32373106 China 4 58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd. 027-50529860
027-50529870 China 2066 56
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
future industrial shanghai co., ltd 400-0066-400;021-60496031
021-55660885 China 2041 65
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 China 19981 64

View Lastest Price from Orphenadrine citrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Orphenadrine citrate
US $8.00 / kg 1kg 99% 100MT career henan chemical co

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