LOXO-292
- CAS No.
- 2152628-33-4
- Chemical Name:
- LOXO-292
- Synonyms
- SELPERCATINIB;LOX-292;CPD2206;LOX0292;LOXO-292;ARRY-192);Serpatinib;LOXO-292 USP/EP/BP;Inhibitor LOXO-292;LOXO-292,Selpercatinib
- CBNumber:
- CB34805442
- Molecular Formula:
- C29H31N7O3
- Molecular Weight:
- 525.6
- MDL Number:
- MFCD31814089
- MOL File:
- 2152628-33-4.mol
| Density | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM) |
| form | A crystalline solid |
| pka | 14.00±0.29(Predicted) |
| InChIKey | XIIOFHFUYBLOLW-UHFFFAOYSA-N |
| SMILES | C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1 |
| FDA UNII | CEGM9YBNGD |
| NCI Drug Dictionary | selpercatinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
LOXO-292 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 10mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 50mg | $1100 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573122 | LOXO-292(Selpercatinib) >98% | 2152628-33-4 | 100mg | $1283.5 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 100mg | $1800 | 2021-12-16 | Buy |
LOXO-292 Chemical Properties,Uses,Production
Binding Mode
In the co-crystal structure of selpercatinib-RET
kinase, the pyrazolopyridine occupies the
adenosine pocket, forming a direct hydrogen bond
between N1 and amide NH of Ala807 and an indirect
hydrogen bond between C6 ether oxygen and amide
NH of Gly810 via a bound water molecule. In addition,
one piperazine nitrogen also interact with one water
molecule (Figs. 3, 4).
Uses
Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").
brand name
Retevmo
General Description
Class: receptor tyrosine kinase; Treatment: RET-altered lung/thyroid cancers; Other name: ARRY-192, LOXO-292; Oral bioavailability = 73%; Elimination half-life = 32 h; Protein binding = 97%
Side effects
Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.
Selpercatinib may cause harm to a developing fetus or a newborn baby.
target
RET
storage
Store at -20°C
Dosage
The recommended selpercatinib dose based on body weight is:
(1) Less than 50 kg: 120 mg orally twice daily
(2) 50 kg or greater: 160 mg orally twice daily
LOXO-292 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 225 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | maguanglei@zisonpharm.com | China | 57 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 159 | 58 |
| Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 73 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 940 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 269 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | admin@hblongbang.com | China | 914 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
Related articles
- LOXO-292: A Promising RET Inhibitor with Strong Anti-Tumor Effects and Manageable Adverse Events
- LOXO-292 inhibits RET-pathway, demonstrating anti-tumor effects and dose-proportional pharmacokinetics. Common adverse events ....
- Mar 4，2024
- Selpercatinib: Synthesis and Description
- Selpercatinib (LOXO-292) is synthesised using sulfonyl chloride as a raw material by chemical reaction.
- Jan 5，2024
- LOXO-292: Bioactivity and Chemicaland toxicological studies
- LOXO-292 is a selective and potent RET inhibitor,it is a novel broad-spectrum anticancer?drug with the targeted?function for R....
- Dec 20，2022
View Lastest Price from LOXO-292 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-06-03 | LOXO-292
2152628-33-4
|
US $6.00 / kg | 1kg | More than 99% | 2000KG/Month | Hebei Longbang Technology Co., Ltd | |
 |
2024-06-03 | Selpercatinib
2152628-33-4
|
US $80.00-60.00 / kg | 1kg | 99% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-06-03 | LOXO-292
2152628-33-4
|
US $50.00-30.00 / KG | 1KG | 99% | 500 | hebei hongtan Biotechnology Co., Ltd |
-
- LOXO-292
2152628-33-4
- US $6.00 / kg
- More than 99%
- Hebei Longbang Technology Co., Ltd
-
- Selpercatinib
2152628-33-4
- US $80.00-60.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- LOXO-292
2152628-33-4
- US $50.00-30.00 / KG
- 99%
- hebei hongtan Biotechnology Co., Ltd