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4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Structure
4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine structure
CAS No.
659729-09-6
Chemical Name:
4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine
Synonyms
4-Chloro-6-(4-(trifluoromethyl);PYRIMIDINE, 4-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]-
CBNumber:
CB41120912
Molecular Formula:
C11H6ClF3N2
Molecular Weight:
258.63
MDL Number:
MFCD09839523
MOL File:
659729-09-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:54
Product description Number Pack Size Price
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 0122AC 100mg $165
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 95+% 097807 250mg $341
4-CHLORO-6-(4'-(TRIFLUOROMETHYL)PHENYL)PYRIMIDINE 95.00% HCH0358919 5MG $499.55
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 0122AC 1g $505
4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 95+% 097807 1g $756
Request For Quotation

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Properties

Boiling point 318.7±37.0 °C(Predicted)
Density 1.385±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -1.61±0.18(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 0122AC 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 659729-09-6 100mg $165 2021-12-16 Buy
Matrix Scientific 097807 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 95+% 659729-09-6 250mg $341 2021-12-16 Buy
American Custom Chemicals Corporation HCH0358919 4-CHLORO-6-(4'-(TRIFLUOROMETHYL)PHENYL)PYRIMIDINE 95.00% 659729-09-6 5MG $499.55 2021-12-16 Buy
AK Scientific 0122AC 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 659729-09-6 1g $505 2021-12-16 Buy
Matrix Scientific 097807 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 95+% 659729-09-6 1g $756 2021-12-16 Buy
Product number Packaging Price Buy
0122AC 100mg $165 Buy
097807 250mg $341 Buy
HCH0358919 5MG $499.55 Buy
0122AC 1g $505 Buy
097807 1g $756 Buy

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Chemical Properties,Uses,Production

Synthesis

4,6-Dichloropyrimidine

1193-21-1

4-Trifluoromethylphenylboronic acid

128796-39-4

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine

659729-09-6

General procedure: All solvents and solutions used for the reaction are degassed with argon for 15 minutes. Under argon protection, 4,6-dichloropyrimidine (1.5 eq.) was dissolved in THF (1 M) in a round bottom flask. Subsequently, 4-trifluoromethylphenylboronic acid (1.0 eq.), palladium acetate (0.02 eq., 2 mol%), triphenylphosphine (0.04 eq., 4 mol%), and 1M aqueous Na2CO3 solution (2.0 eq.) were added. The reaction mixture was stirred at 60°C overnight. After completion of the reaction, it was cooled to room temperature and extracted with an aqueous layer and Et2O. The organic layers were combined, washed with brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography to afford the target compound 4-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 2, p. 299 - 302
[2] Patent: CN106632488, 2017, A. Location in patent: Paragraph 0167-0169
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3497 - 3514
[4] Patent: US2006/241296, 2006, A1. Location in patent: Page/Page column 27
[5] Patent: WO2010/134478, 2010, A1. Location in patent: Page/Page column 165

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dichloropyrimidine 4-Trifluoromethylphenylboronic acid Tetrahydrofuran Triphenylphosphine Water
Sodium carbonate Palladium (II) Acetate

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Preparation Products

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Litong Chemical Technology Co.,Ltd. 13598610367 0373-7129549 2468833170@qq.com China 932 58
NovoChemy Ltd. 021-31261262/ 49 (0)17662837245 sales@novochemy.com Germany 6328 58
SynAsst Chemical. 021-60343070 China 12740 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7865 55
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Fuxin Pharmaceutical 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Litong Chemical Technology Co.,Ltd. 58
NovoChemy Ltd. 58
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Cochemical Ltd. 58

659729-09-6(4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine)Related Search:

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4-Chloro-6-(2-fluoro-4-trifluoromethyl-phenyl)-pyrimidine

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4-Chloro-6-(4-(trifluoromethyl) PYRIMIDINE, 4-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]- 659729-09-6