4-Chlorobenzhydrylchloride
- CAS No.
- 134-83-8
- Chemical Name:
- 4-Chlorobenzhydrylchloride
- Synonyms
- UNII:LC0K0NYJ2N;4-Chlorobenzhydrylch;LABOTEST-BB LT00160064;P-CHLOROBENZHYDRYL CHLORIDE;4-CHLOROBENZHYDRYL CHLORIDE;à,4-dichlorodiphenylmethane;?,4-dichloro-?-phenyltoluene;α,4-dichloro-α-phenyltoluene;4-Chlorodiphenylmethylchloride;Para Chlorobenzhydryl Chloride
- CBNumber:
- CB4153609
- Molecular Formula:
- C13H10Cl2
- Molecular Weight:
- 237.12
- MDL Number:
- MFCD00000856
- MOL File:
- 134-83-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Chlorobenzhydryl Chloride | C1234 | 25G | $39 |
| 4-Chlorobenzhydryl Chloride | C1234 | 500G | $305 |
| 1-Chloro-4-(chlorophenylmethyl)benzene | C364855 | 25g | $85 |
| 4-Chlorobenzhydryl Chloride | OR40704 | 500g | $138 |
| 1-Chloro-4-(chloro(phenyl)methyl)benzene 98% | 093712 | 100g | $152 |
| More product size | |||
| Boiling point | 159-160 °C2 mm Hg(lit.) |
|---|---|
| Density | 1.239 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | IMMISCIBLE |
| Sensitive | Moisture Sensitive |
| BRN | 2050236 |
| CAS DataBase Reference | 134-83-8(CAS DataBase Reference) |
| FDA UNII | LC0K0NYJ2N |
| NIST Chemistry Reference | Benzene, 1-chloro-4-(chlorophenylmethyl)-(134-83-8) |
| EPA Substance Registry System | Benzene, 1-chloro-4-(chlorophenylmethyl)- (134-83-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317-H318-H400-H410 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P501a-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-36/37-36 | |||||||||
| Safety Statements | 26-27-36/37/39-45 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29036990 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-Chlorobenzhydrylchloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1234 | 4-Chlorobenzhydryl Chloride | 134-83-8 | 25G | $39 | 2026-03-19 | Buy |
| TCI Chemical | C1234 | 4-Chlorobenzhydryl Chloride | 134-83-8 | 500G | $305 | 2026-03-19 | Buy |
| TRC | C364855 | 1-Chloro-4-(chlorophenylmethyl)benzene | 134-83-8 | 25g | $85 | 2021-12-16 | Buy |
| Apolloscientific | OR40704 | 4-Chlorobenzhydryl Chloride | 134-83-8 | 500g | $138 | 2021-12-16 | Buy |
| Matrix Scientific | 093712 | 1-Chloro-4-(chloro(phenyl)methyl)benzene 98% | 134-83-8 | 100g | $152 | 2021-12-16 | Buy |
4-Chlorobenzhydrylchloride Chemical Properties,Uses,Production
Chemical Properties
clear light yellow liquid
Uses
1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.
Preparation
Preparation of 4-Chlorobenzhydryl Chloride (4-CBC): The 4-chlorobenzhydrol (4-CB) in 15 mL of toluene, obtained from the previous step, was mixed with 10 mL of conc. HCl at 60oC maintained at the same temperature for 2.5 h. The reaction mixture was cooled to 20oC to separate into organic and aqueous layers. The toluene layer was washed with 10 % aq. sodium carbonate to pH 7, dried over anhydrous sodium sulphate and taken to next step without isolation.
Synthesis
119-56-2
134-83-8
GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of benzophenone (1.0 mol) in methanol (2 vol) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC) and subsequently diluted with water (750 mL) and pH adjusted with acetic acid to 4. The reaction mixture was extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the pure diphenylmethanol derivative as a white to off-white solid in 93-97% yield. To a stirred solution of diphenylmethanol derivative (1.0 mol) in toluene (370 mL) at room temperature was sequentially added concentrated HCl (35% aqueous solution, 370 mL) and tetrabutylammonium bromide (0.01 mol). The reaction mixture was stirred at 40-45 °C for 6-7 hours. After confirming the completion of the reaction by TLC, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to afford the crude diphenylmethyl chloride derivative as a light brown liquid in 95-97% yield. Anhydrous piperazine (5.0 mol) was slowly added to a solution of diphenylmethyl chloride derivative (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated with stirring at 90-100°C for 8-10 hours. After completion of the reaction, the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a mixture of concentrated HCl and water (1:1, 2 x 350 mL) and neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2 × 300 mL), and the combined organic layers were dried with anhydrous sodium sulfate and concentrated in vacuum to afford the pure diphenylmethylpiperazine compounds (2a-c) as white to off-white solids in 88% yield.
References
[1] Australian Journal of Chemistry, 2006, vol. 59, # 7, p. 445 - 456
[2] Journal of the American Chemical Society, 1928, vol. 50, p. 1804
[3] Synthesis, 1976, p. 326 - 329
[4] Journal of Medicinal and Pharmaceutical Chemistry, 1962, vol. 5, p. 1008 - 1015
4-Chlorobenzhydrylchloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
View Lastest Price from 4-Chlorobenzhydrylchloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | 4-Chlorobenzhydrylchloride
134-83-8
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2020-01-13 | 4-Chlorobenzhydrylchloride
134-83-3
|
US $1.00 / KG | 1KG | 98%-99.9% | 100kg | Career Henan Chemical Co | |
 |
2019-07-06 | 4-Chlorobenzhydrylchloride
134-83-8
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 4-Chlorobenzhydrylchloride
134-83-8
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chlorobenzhydrylchloride
134-83-3
- US $1.00 / KG
- 98%-99.9%
- Career Henan Chemical Co
-
- 4-Chlorobenzhydrylchloride
134-83-8
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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